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Prostate Cancer Clinical Trials Recruiting in the US

577 studies for Prostate Cancer are recruiting at 5,745 US sites, according to ClinicalTrials.gov data processed .

Prostate cancer is a disease in which cells in the prostate gland grow out of control.

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Recruiting now

Top Prostate Cancer studies by number of US sites

Showing 30 studies, most US recruiting sites first.
  1. Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

    NCT05334069

    • Observational
    • Ages 40 to 75 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    610 US recruiting sites
  2. Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

    NCT05946213

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    397 US recruiting sites
  3. Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

    NCT06592924

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    358 US recruiting sites
  4. Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

    NCT03678025

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    292 US recruiting sites
  5. Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

    NCT04423211

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    278 US recruiting sites
  6. Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

    NCT03866382

    • Phase 2
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    217 US recruiting sites
  7. Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

    NCT06931340

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    204 US recruiting sites
  8. Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body

    NCT06470243

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    173 US recruiting sites
  9. Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

    NCT05806515

    • Phase 2
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    132 US recruiting sites
  10. This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

    NCT07028853

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    125 US recruiting sites
  11. Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

    NCT06632977

    • Phase 2
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    99 US recruiting sites
  12. Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

    NCT07200830

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    92 US recruiting sites
  13. SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    NCT03452774

    • Observational
    • Ages Any age
    • Sex: All
    Recruiting sites
    67 US recruiting sites
  14. A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

    NCT07225946

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    59 US recruiting sites
  15. A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

    NCT06136650

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    52 US recruiting sites
  16. A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)

    NCT07164443

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    52 US recruiting sites
  17. Vitamin D for Prostate Endocrine Therapy

    NCT05838716

    • Phase 3
    • Ages 50 years and older
    • Sex: Male
    Recruiting sites
    51 US recruiting sites
  18. A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

    NCT06925737

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    51 US recruiting sites
  19. Androgen Suppression Combined With Nodal Irradiation and Dose Escalated Prostate Treatment

    NCT06235697

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    46 US recruiting sites
  20. A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

    NCT07213674

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    45 US recruiting sites
  21. The Vanguard Study: Testing a New Way to Screen for Cancer

    NCT06995898

    • Interventional
    • Ages 45 to 75 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    43 US recruiting sites
  22. Integrated Cancer Repository for Cancer Research

    NCT02012699

    • Observational
    • Ages 19 to 110 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    42 US recruiting sites
  23. Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

    NCT06855277

    • Phase 3
    • Ages 18 to 100 years
    • Sex: Male
    Recruiting sites
    42 US recruiting sites
  24. Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

    NCT05176483

    • Phase 1
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    39 US recruiting sites
  25. A Study to Learn How PF-06821497 (Mevrometostat) Works in Men With Metastatic Castration-resistant Prostate Cancer.

    NCT06629779

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    39 US recruiting sites
  26. An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan Versus Observation in PSMA Positive OMPC.

    NCT05939414

    • Phase 3
    • Ages 18 to 100 years
    • Sex: Male
    Recruiting sites
    37 US recruiting sites
  27. A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

    NCT06952803

    • Phase 3
    • Ages 18 years and older
    • Sex: Male
    Recruiting sites
    37 US recruiting sites
  28. International Registry for Men With Advanced Prostate Cancer (IRONMAN)

    NCT03151629

    • Observational
    • Ages 21 years and older
    • Sex: Male
    Recruiting sites
    35 US recruiting sites
  29. Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

    NCT06780670

    • Phase 2/3
    • Ages 18 to 100 years
    • Sex: Male
    Recruiting sites
    35 US recruiting sites
  30. Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)

    NCT05519449

    • Phase 1
    • Ages 18 to 100 years
    • Sex: Male
    Recruiting sites
    33 US recruiting sites

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Prostate Cancer clinical trials by city

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Prostate Cancer clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.