Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response
NCT06592924
This study is recruiting at 358 US sites in 40 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is being done to answer the following question: can the chance of prostate cancer growing or spreading be lowered by adding a drug to the usual combination of drugs? This study would like to find out if this approach is better or worse than the usual approach for prostate cancer. The usual approach for patients who are not in a study is hormone treatment with Androgen Deprivation Therapy (ADT) and Androgen-Receptor Pathway Inhibitor (ARPI).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Prostate Cancer (Adenocarcinoma)
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- Canadian Cancer Trials Group
- Last updated on ClinicalTrials.gov
- July 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 7
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
- Fairbanks Memorial Hospital · Fairbanks, AK
Arizona · 1
- Cancer Center at Saint Joseph's · Phoenix, AZ
California · 50
- Kaiser Permanente-Anaheim · Anaheim, CA
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- Kaiser Permanente-Baldwin Park · Baldwin Park, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Stanford Cancer Center Emeryville · Emeryville, CA
- Kaiser Permanente-Fontana · Fontana, CA
- Kaiser Permanente South Bay · Harbor City, CA
- City of Hope at Irvine Lennar · Irvine, CA
- Kaiser Permanente-Irvine · Irvine, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- City of Hope Antelope Valley · Lancaster, CA
- City of Hope at Long Beach Elm · Long Beach, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Kaiser Permanente West Los Angeles · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Mercy Cancer Center · Merced, CA
- Providence Queen of The Valley · Napa, CA
- USC Norris Oncology/Hematology-Newport Beach · Newport Beach, CA
- Kaiser Permanente-Ontario · Ontario, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Stanford Cancer Institute Palo Alto · Palo Alto, CA
- VA Palo Alto Health Care System · Palo Alto, CA
- Kaiser Permanente - Panorama City · Panorama City, CA
- Keck Medical Center of USC Pasadena · Pasadena, CA
- Kaiser Permanente-Riverside · Riverside, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Kaiser Permanente-San Diego Zion · San Diego, CA
- Stanford Cancer Center South Bay · San Jose, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Kaiser Permanente-San Marcos · San Marcos, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Providence Santa Rosa Memorial Hospital · Santa Rosa, CA
- City of Hope South Pasadena · South Pasadena, CA
- Saint Joseph's Medical Center · Stockton, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- City of Hope South Bay · Torrance, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- City of Hope Upland · Upland, CA
- Woodland Memorial Hospital · Woodland, CA
- Kaiser Permanente-Woodland Hills · Woodland Hills, CA
Colorado · 21
- UCHealth University of Colorado Hospital · Aurora, CO
- Memorial Hospital North · Colorado Springs, CO
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- UCHealth - Cherry Creek · Denver, CO
- Dillon Health Center/Shaw Cancer Center · Dillon, CO
- CommonSpirit Cancer Center Mercy · Durango, CO
- Mercy Medical Center · Durango, CO
- Shaw Cancer Center · Edwards, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- CommonSpirit Saint Anthony Hospital Cancer Center · Lakewood, CO
- UCHealth Lone Tree Health Center · Lone Tree, CO
- Longmont United Hospital · Longmont, CO
- Medical Center of the Rockies · Loveland, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- Saint Anthony North Hospital · Westminster, CO
Connecticut · 1
- Veterans Affairs Connecticut Healthcare System-West Haven Campus · West Haven, CT
Delaware · 7
- Beebe Medical Center · Lewes, DE
- Beebe South Coastal Health Campus · Millville, DE
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
District of Columbia · 2
- George Washington University Medical Center · Washington D.C., DC
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 13
- Mount Sinai Comprehensive Cancer Center at Aventura · Aventura, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Coral Springs · Coral Springs, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- Malcom Randall Veterans Administration Medical Center · Gainesville, FL
- UM Sylvester Comprehensive Cancer Center at Hollywood · Hollywood, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Mount Sinai Medical Center · Miami Beach, FL
- University of Miami Sylvester Comprehensive Cancer Center at Sole Mia · North Miami, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- Cleveland Clinic-Weston · Weston, FL
Georgia · 7
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Atlanta VA Medical Center · Decatur, GA
- Emory Decatur Hospital · Decatur, GA
- Emory Johns Creek Hospital · Johns Creek, GA
Hawaii · 17
- Hawaii Cancer Care - Westridge · ‘Aiea, HI
- Pali Momi Medical Center · ‘Aiea, HI
- Queen's Cancer Center - Pearlridge · ‘Aiea, HI
- Straub Pearlridge Clinic · ‘Aiea, HI
- The Queen's Medical Center - West Oahu · ‘Ewa Beach, HI
- Hawaii Cancer Care Inc - Waterfront Plaza · Honolulu, HI
- Hawaii Diagnostic Radiology Services LLC · Honolulu, HI
- Kapiolani Medical Center for Women and Children · Honolulu, HI
- Kuakini Medical Center · Honolulu, HI
- Queen's Cancer Cenrer - POB I · Honolulu, HI
- Queen's Cancer Center - Kuakini · Honolulu, HI
- Queen's Medical Center · Honolulu, HI
- Straub Clinic and Hospital · Honolulu, HI
- Tripler Army Medical Center · Honolulu, HI
- University of Hawaii Cancer Center · Honolulu, HI
- Straub Medical Center - Kahului Clinic · Kahului, HI
- Wilcox Memorial Hospital and Kauai Medical Clinic · Lihue, HI
Idaho · 8
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 6
- University of Illinois · Chicago, IL
- Elmhurst Memorial Hospital · Elmhurst, IL
- Edward Hospital/Cancer Center · Naperville, IL
- Edward Hospital/Cancer Center?Plainfield · Plainfield, IL
- Memorial Hospital East · Shiloh, IL
- Midwestern Regional Medical Center · Zion, IL
Iowa · 10
- UI Health Care Mission Cancer and Blood - Ankeny Clinic · Ankeny, IA
- Saint Anthony Regional Hospital · Carroll, IA
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
- Mercy Cancer Center-West Lakes · Clive, IA
- UI Health Care Mission Cancer and Blood - West Des Moines Clinic · Clive, IA
- Greater Regional Medical Center · Creston, IA
- Broadlawns Medical Center · Des Moines, IA
- Iowa Methodist Medical Center · Des Moines, IA
- Mercy Medical Center - Des Moines · Des Moines, IA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.