Study of JANX007 in Subjects With Metastatic Castration-Resistant Prostate Cancer (ENGAGER-PSMA-01)
NCT05519449
This study is recruiting at 33 US sites in 17 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is a first-in-human, Phase 1, open-label, multicenter study to assess the safety, tolerability, pharmacokinetic (PK), pharmacodynamic (PD), and the preliminary efficacy of JANX007 in adults with metastatic castration-resistant prostate cancer (mCRPC).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Prostate Cancer
- Metastatic Castration-resistant Prostate Cancer
- Castration Resistant Prostatic Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 18 to 100 years
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- Janux Therapeutics
- Last updated on ClinicalTrials.gov
- August 13, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Hospital · Birmingham, AL
Arizona · 1
- Mayo Clinic · Phoenix, AZ
California · 5
- UCLA Department of Medicine · Los Angeles, CA
- USC Norris Comprehensive Cancer Center · Los Angeles, CA
- Hoag Memorial Hospital Presbyterian · Newport Beach, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- UCSF Helen Diller Family Comprehensive Cancer Center · San Francisco, CA
Connecticut · 1
- Yale New Haven Hospital · New Haven, CT
Florida · 1
- Mayo Clinic · Jacksonville, FL
Illinois · 1
- University of Chicago Medical Center · Chicago, IL
Maryland · 1
- University of Maryland Greenebaum Comprehensive Cancer Center · Baltimore, MD
Minnesota · 2
- University of Minnesota Medical Center · Minneapolis, MN
- Mayo Clinic · Rochester, MN
Missouri · 1
- Washington University School of Medicine · St Louis, MO
New York · 6
- Northwell Health R.J. Zuckerberg Cancer Hospital · Lake Success, NY
- NYU Langone Health Long Island · Mineola, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- NYU Langone Health · New York, NY
- Weill Cornell Medicine · New York, NY
- Montefiore Medical Center · The Bronx, NY
Ohio · 2
- University of Cincinnati Medical Center · Cincinnati, OH
- The Ohio State University · Columbus, OH
Pennsylvania · 3
- Penn State Milton S. Hershey Medical Center · Hershey, PA
- Thomas Jefferson University Honickman Center · Philadelphia, PA
- UPMC Hillman Cancer Center · Pittsburgh, PA
Rhode Island · 1
- Rhode Island Hospital · Providence, RI
South Carolina · 1
- Medical University of South Carolina · Charleston, SC
Tennessee · 1
- Sarah Cannon Research · Nashville, TN
Texas · 3
- Mary Crowley Cancer Research · Dallas, TX
- University of Texas Southwestern Medical Center · Dallas, TX
- Houston Methodist Hospital · Houston, TX
Wisconsin · 2
- University of Wisconsin Carbone Cancer Center · Madison, WI
- Froedtert Hospital and the Medical College of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.