Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
NCT04423211
This study is recruiting at 278 US sites in 32 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial tests two questions by two separate comparisons of therapies. The first question is whether enhanced therapy (apalutamide in combination with abiraterone + prednisone) added to standard of care (prostate radiation therapy and short term androgen deprivation) is more effective compared to standard of care alone in patients with prostate cancer who experience biochemical recurrence (a rise in the blood level of prostate specific antigen [PSA] after surgical removal of the prostate cancer).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Biochemically Recurrent Prostate Carcinoma
- Metastatic Prostate Carcinoma
- Prostate Adenocarcinoma
- Stage IVB Prostate Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- ECOG-ACRIN Cancer Research Group
- Last updated on ClinicalTrials.gov
- August 19, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 7
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
- Fairbanks Memorial Hospital · Fairbanks, AK
Arizona · 1
- Cancer Center at Saint Joseph's · Phoenix, AZ
Arkansas · 1
- Mercy Hospital Fort Smith · Fort Smith, AR
California · 20
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- City of Hope Corona · Corona, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- UC San Diego Health System - Encinitas · Encinitas, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- City of Hope Antelope Valley · Lancaster, CA
- UCLA / Jonsson Comprehensive Cancer Center · Los Angeles, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- UC San Diego Medical Center - Hillcrest · San Diego, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- City of Hope South Pasadena · South Pasadena, CA
- Saint Joseph's Medical Center · Stockton, CA
- City of Hope Upland · Upland, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 9
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- Dillon Health Center/Shaw Cancer Center · Dillon, CO
- Shaw Cancer Center · Edwards, CO
- CommonSpirit Saint Anthony Hospital Cancer Center · Lakewood, CO
- Longmont United Hospital · Longmont, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- Saint Anthony North Hospital · Westminster, CO
District of Columbia · 1
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 4
- Moffitt Cancer Center · Tampa, FL
- Moffitt Cancer Center - McKinley Campus · Tampa, FL
- Moffitt Cancer Center-International Plaza · Tampa, FL
- Moffitt Cancer Center at Wesley Chapel · Wesley Chapel, FL
Idaho · 7
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Saint Luke's Cancer Institute - Twin Falls · Twin Falls, ID
Illinois · 45
- Alton Memorial Hospital · Alton, IL
- OSF Saint Anthony's Health Center · Alton, IL
- Rush-Copley Medical Center · Aurora, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Northwestern University · Chicago, IL
- Rush MD Anderson Cancer Center · Chicago, IL
- University of Illinois · Chicago, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Rush MD Anderson Cancer Center at Rush Lisle · Lisle, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Rush MD Anderson Cancer Center at Rush Oak Park · Oak Park, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- Carle Cancer Center · Urbana, IL
- The Carle Foundation Hospital · Urbana, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Iowa · 2
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
Kansas · 2
- Central Care Cancer Center - Garden City · Garden City, KS
- Mercy Hospital Pittsburg · Pittsburg, KS
Kentucky · 3
- CommonSpirit Saint Joseph Hospital - Lexington · Lexington, KY
- CommonSpirit Saint Joseph Medical Center - East Lexington · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
Louisiana · 2
- LSU Health Baton Rouge-North Clinic · Baton Rouge, LA
- Our Lady of the Lake Physician Group · Baton Rouge, LA
Maryland · 2
- Johns Hopkins University/Sidney Kimmel Cancer Center · Baltimore, MD
- Suburban Hospital · Bethesda, MD
Minnesota · 24
- Minnesota Oncology - Burnsville · Burnsville, MN
- Minnesota Oncology Hematology PA-Chaska · Chaska, MN
- Mercy Hospital · Coon Rapids, MN
- Minnesota Oncology - Coon Rapids · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
- Minnesota Oncology - Edina · Edina, MN
- Fairview Clinics and Surgery Center Maple Grove · Maple Grove, MN
- Minnesota Oncology - Maple Grove · Maple Grove, MN
- Minnesota Oncology Hematology PA-Maplewood · Maplewood, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Health Partners Inc · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- Monticello Cancer Center · Monticello, MN
- North Memorial Medical Health Center · Robbinsdale, MN
- Coborn Cancer Center at Saint Cloud Hospital · Saint Cloud, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Lakeview Hospital · Stillwater, MN
- Ridgeview Medical Center · Waconia, MN
- Rice Memorial Hospital · Willmar, MN
- Minnesota Oncology Hematology PA-Woodbury · Woodbury, MN
Mississippi · 3
- Baptist Cancer Center-Grenada · Grenada, MS
- Baptist Memorial Hospital and Cancer Center-Union County · New Albany, MS
- Baptist Memorial Hospital and Cancer Center-Oxford · Oxford, MS
Missouri · 17
- Central Care Cancer Center - Bolivar · Bolivar, MO
- Mercy Cancer Center - Cape Girardeau · Cape Girardeau, MO
- Saint Francis Medical Center · Cape Girardeau, MO
- Siteman Cancer Center at Saint Peters Hospital · City of Saint Peters, MO
- Siteman Cancer Center at West County Hospital · Creve Coeur, MO
- Parkland Health Center - Farmington · Farmington, MO
- Freeman Health System · Joplin, MO
- Mercy Hospital Joplin · Joplin, MO
- Lake Regional Hospital · Osage Beach, MO
- Mercy Clinic-Rolla-Cancer and Hematology · Rolla, MO
- Phelps Health Delbert Day Cancer Institute · Rolla, MO
- Heartland Regional Medical Center · Saint Joseph, MO
- Sainte Genevieve County Memorial Hospital · Sainte Genevieve, MO
- CoxHealth South Hospital · Springfield, MO
- Mercy Hospital Springfield · Springfield, MO
- Mercy Hospital Saint Louis · St Louis, MO
- Mercy Hospital South · St Louis, MO
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.