Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer
NCT03678025
This study is recruiting at 292 US sites in 39 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial studies how well standard systemic therapy with or without definitive treatment (prostate removal surgery or radiation therapy) works in treating participants with prostate cancer that has spread to other places in the body. Addition of prostate removal surgery or radiation therapy to standard systemic therapy for prostate cancer may lower the chance of the cancer growing or spreading.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Castration Levels of Testosterone
- Metastatic Prostatic Adenocarcinoma
- Stage IV Prostate Cancer AJCC v8
- Stage IVA Prostate Cancer AJCC v8
- Stage IVB Prostate Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- October 8, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 4
- Banner MD Anderson Cancer Center · Gilbert, AZ
- Cancer Center at Saint Joseph's · Phoenix, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
- University of Arizona Cancer Center-Orange Grove Campus · Tucson, AZ
Arkansas · 1
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 42
- Kaiser Permanente-Deer Valley Medical Center · Antioch, CA
- Community Cancer Institute · Clovis, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Kaiser Permanente Dublin · Dublin, CA
- Kaiser Permanente-Fremont · Fremont, CA
- Fresno Cancer Center · Fresno, CA
- Kaiser Permanente-Fresno · Fresno, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Tibor Rubin VA Medical Center · Long Beach, CA
- Los Angeles County-USC Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Fremont - Rideout Cancer Center · Marysville, CA
- Kaiser Permanente-Modesto · Modesto, CA
- Kaiser Permanente Oakland-Broadway · Oakland, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Desert Regional Medical Center · Palm Springs, CA
- Stanford Cancer Institute Palo Alto · Palo Alto, CA
- Kaiser Permanente-Rancho Cordova Cancer Center · Rancho Cordova, CA
- Kaiser Permanente-Redwood City · Redwood City, CA
- Kaiser Permanente-Richmond · Richmond, CA
- Rohnert Park Cancer Center · Rohnert Park, CA
- Kaiser Permanente-Roseville · Roseville, CA
- The Permanente Medical Group-Roseville Radiation Oncology · Roseville, CA
- Kaiser Permanente Downtown Commons · Sacramento, CA
- Kaiser Permanente-South Sacramento · Sacramento, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- South Sacramento Cancer Center · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- Kaiser Permanente-Santa Teresa-San Jose · San Jose, CA
- Kaiser Permanente San Leandro · San Leandro, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Kaiser San Rafael-Gallinas · San Rafael, CA
- Kaiser Permanente Medical Center - Santa Clara · Santa Clara, CA
- Kaiser Permanente-Santa Rosa · Santa Rosa, CA
- Kaiser Permanente Cancer Treatment Center · South San Francisco, CA
- Kaiser Permanente-South San Francisco · South San Francisco, CA
- Kaiser Permanente-Stockton · Stockton, CA
- Gene Upshaw Memorial Tahoe Forest Cancer Center · Truckee, CA
- Kaiser Permanente Medical Center-Vacaville · Vacaville, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- Kaiser Permanente-Walnut Creek · Walnut Creek, CA
Colorado · 11
- University of Colorado Hospital · Aurora, CO
- Rocky Mountain Cancer Centers-Boulder · Boulder, CO
- Memorial Hospital North · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- Porter Adventist Hospital · Denver, CO
- Shaw Cancer Center · Edwards, CO
- Poudre Valley Hospital · Fort Collins, CO
- North Colorado Medical Center · Greeley, CO
- Littleton Adventist Hospital · Littleton, CO
- McKee Medical Center · Loveland, CO
- Parker Adventist Hospital · Parker, CO
Connecticut · 6
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Yale University · New Haven, CT
- Stamford Hospital/Bennett Cancer Center · Stamford, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
- Veterans Affairs Connecticut Healthcare System-West Haven Campus · West Haven, CT
Delaware · 2
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
District of Columbia · 1
- George Washington University Medical Center · Washington D.C., DC
Florida · 8
- Mount Sinai Comprehensive Cancer Center at Aventura · Aventura, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- Baptist MD Anderson Cancer Center · Jacksonville, FL
- UM Sylvester Comprehensive Cancer Center at Kendall · Miami, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Mount Sinai Medical Center · Miami Beach, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
Georgia · 6
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Augusta University Medical Center · Augusta, GA
- Atlanta VA Medical Center · Decatur, GA
Idaho · 3
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
Illinois · 21
- Rush - Copley Medical Center · Aurora, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Rush University Medical Center · Chicago, IL
- University of Illinois · Chicago, IL
- Decatur Memorial Hospital · Decatur, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Loyola University Medical Center · Maywood, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- OSF Saint Francis Medical Center · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Carle Cancer Center · Urbana, IL
Indiana · 1
- Reid Health · Richmond, IN
Iowa · 3
- McFarland Clinic - Ames · Ames, IA
- Iowa Methodist Medical Center · Des Moines, IA
- University of Iowa/Holden Comprehensive Cancer Center · Iowa City, IA
Kansas · 4
- University of Kansas Cancer Center · Kansas City, KS
- Olathe Health Cancer Center · Olathe, KS
- University of Kansas Cancer Center-Overland Park · Overland Park, KS
- University of Kansas Hospital-Westwood Cancer Center · Westwood, KS
Kentucky · 3
- Saint Joseph Hospital East · Lexington, KY
- Saint Joseph Radiation Oncology Resource Center · Lexington, KY
- The James Graham Brown Cancer Center at University of Louisville · Louisville, KY
Louisiana · 2
- East Jefferson General Hospital · Metairie, LA
- LSU Healthcare Network / Metairie Multi-Specialty Clinic · Metairie, LA
Maine · 6
- MaineHealth Coastal Cancer Treatment Center · Bath, ME
- Lafayette Family Cancer Center-EMMC · Brewer, ME
- Maine Medical Center-Bramhall Campus · Portland, ME
- MaineHealth Cancer Care Center of York County · Sanford, ME
- MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford · Sanford, ME
- Maine Medical Center- Scarborough Campus · Scarborough, ME
Michigan · 20
- Saint Joseph Mercy Hospital · Ann Arbor, MI
- University of Michigan Comprehensive Cancer Center · Ann Arbor, MI
- Saint Joseph Mercy Brighton · Brighton, MI
- Saint Joseph Mercy Canton · Canton, MI
- Saint Joseph Mercy Chelsea · Chelsea, MI
- GenesisCare USA - Clarkston · Clarkston, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Hospital · Detroit, MI
- Wayne State University/Karmanos Cancer Institute · Detroit, MI
- GenesisCare USA - Farmington Hills · Farmington Hills, MI
- Spectrum Health at Butterworth Campus · Grand Rapids, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Sparrow Hospital · Lansing, MI
- GenesisCare USA - Macomb · Macomb, MI
- GenesisCare USA - Madison Heights · Madison Heights, MI
- 21st Century Oncology-Pontiac · Pontiac, MI
- Ascension Saint Mary's Hospital · Saginaw, MI
- Munson Medical Center · Traverse City, MI
- GenesisCare USA - Troy · Troy, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
Minnesota · 6
- Mercy Hospital · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
- Unity Hospital · Fridley, MN
- Health Partners Inc · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- North Memorial Medical Health Center · Robbinsdale, MN
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.