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Prostate Cancer Clinical Trials near Durham, NC

47 studies for Prostate Cancer are recruiting at 60 sites within 50 miles of Durham, North Carolina, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Prostate Cancer trials in the US or all trials near Durham.

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Recruiting now

Prostate Cancer studies enrolling near Durham

Showing 47 studies, nearest first.
  1. This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

    NCT07028853

    • Phase 3
    • Ages 18 years and older
    • Sex: Male

    Nearest sites: Duke University (Durham, NC); Duke University Medical Center (location of scans) (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    8 sites within 50 mi
  2. International Registry for Men With Advanced Prostate Cancer (IRONMAN)

    NCT03151629

    • Observational
    • Ages 21 years and older
    • Sex: Male

    Nearest sites: Duke Cancer Network (Durham, NC); Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  3. A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

    NCT05652686

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Duke University Medical Center (Durham, NC); University of North Carolina at Chapel Hill (Chapel Hill, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  4. Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

    NCT06931340

    • Phase 3
    • Ages 18 years and older
    • Sex: Male

    Nearest sites: Duke University Medical Center (Durham, NC); Durham VA Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  5. The Vanguard Study: Testing a New Way to Screen for Cancer

    NCT06995898

    • Interventional
    • Ages 45 to 75 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest sites: Durham VA Medical Center (Durham, NC); UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  6. Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

    NCT04038502

    • Phase 2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Durham VA Medical Center, Durham, NC (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  7. Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer

    NCT04221542

    • Phase 1
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  8. The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

    NCT04585750

    • Phase 1/2
    • Ages 12 years and older
    • Sex: All

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  9. A Safety and Dose-finding Study of PRL-02 Depot in Men With Advanced Prostate Cancer

    NCT04729114

    • Phase 1
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke Cancer Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  10. Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate Cancer

    NCT04787744

    • Phase 2/3
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Durham VA Medical Center, Durham, NC (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  11. High Dose Testosterone for ATM, CDK12 or CHEK2 Altered Prostate Cancers

    NCT05011383

    • Phase 2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Durham VA Medical Center, Durham, NC (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  12. Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

    NCT05176483

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Exelixis Clinical Site #12 (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  13. Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

    NCT05334069

    • Observational
    • Ages 40 to 75 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Durham VA Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  14. Long-Term Safety of Lutetium (177Lu) Vipivotide Tetraxetan in Participants With Prostate Cancer

    NCT05803941

    • Phase 4
    • Ages 18 to 100 years
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. Intermittent Fasting Using a Fasting-Mimicking Diet to Improve Prostate Cancer Control and Metabolic Outcomes

    NCT05832086

    • Phase 2
    • Ages Any age
    • Sex: Male

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  16. FOG-001 in Locally Advanced or Metastatic Solid Tumors

    NCT05919264

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  17. Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

    NCT05946213

    • Phase 3
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Durham VA Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  18. Placebo-Controlled Trial of Urolithin A Supplementation in Men With Prostate Cancer Undergoing Radical Prostatectomy, URO-PRO Trial

    NCT06022822

    • Phase 2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

    NCT06056830

    • Phase 3
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. A Study to Assess BMS-986460 in Participants With Metastatic Castration-resistant Prostate Cancer

    NCT06067841

    • Phase 1
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

    NCT06141993

    • Observational
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. Study of SX-682 Plus Enzalutamide in Men With ARPI-Resistant Metastatic Castration Resistant Prostate Cancer

    NCT06228053

    • Phase 2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  23. A Study of Tinengotinib (TT-00420) in Combination With Standard Treatments in People With Prostate Cancer

    NCT06457919

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. Study Evaluating Dosimetry, Randomized Dose Optimization, Dose Escalation and Efficacy of Ac-225 Rosopatamab Tetraxetan in Participants With PSMA PET-Positive Castration-Resistant Prostate Cancer (CRPC)

    NCT06549465

    • Phase 2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. Engage Psychosocial Intervention for Cancer Symptoms

    NCT06555588

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Network (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

    NCT06778863

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. A Phase 1b/2a Study of Pocenbrodib as Monotherapy and in Combination With Darolutamide in Participants With mCRPC

    NCT06785636

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University medical center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. Study of HLD-0915 (JNJ-101556143) in Patients With Metastatic Prostate Cancer

    NCT06800313

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. Comparing Standard of Care Biopsy System to a Novel Biopsy Needle System by Computational Pathologic Analysis

    NCT06830265

    • Interventional
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. A Study of FG-3246 in Participants With Metastatic Castration-Resistant Prostate Cancer (mCRPC)

    NCT06842498

    • Phase 2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center - Duke Cancer Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. COMPASS Study for Metastatic Castration-resistant Prostate Cancer

    NCT07050433

    • Observational
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

    NCT07103018

    • Phase 1
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke Cancer Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  33. DESTINY-PANTUMOUR04

    NCT07124000

    • Observational
    • Ages 18 to 130 years
    • Sex: All

    Nearest site: Research Site (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. Validation of a Platelet Proteomic Assay for Diagnosing and Monitoring Prostate Cancer

    NCT07144228

    • Observational
    • Ages 40 years and older
    • Sex: Male

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. TulmiSTAR-02: A Phase I/II Open-label Study of Tulmimetostat in Combination With Darolutamide vs. Darolutamide, and Tulmimetostat With Abiraterone in Patients With Metastatic Hormone-sensitive Prostate Cancer (mHSPC)

    NCT07190300

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  36. An Open-label Dose Escalation and Expansion, Followed by a Phase II Study of Tulmimetostat (DZR123) and JSB462 (Luxdegalutamide) in Patients With Progressive Metastatic Castrate Resistant Prostate Cancer (mCRPC) (TulmiSTAR-01)

    NCT07206056

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer

    NCT07225946

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. A Phase Ib/II Open-label Study of AMO959 With Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI in Adult Participants With PSMA-positive mCRPC

    NCT07226986

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke Univ Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  39. Trial of Xaluritamig in Adults With Metastatic Castration-resistant Prostate Cancer

    NCT07493512

    • Phase 1
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    NCT03452774

    • Observational
    • Ages Any age
    • Sex: All

    Nearest site: Massive Bio SYNERGY-AI site (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  41. Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

    NCT03866382

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  42. A Study of NX-1607 in Adults With Advanced Malignancies

    NCT05107674

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: University of North Carolina (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

    NCT06632977

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  44. Designing Visual Tools to Enhance Cancer Surgeon Decision-making

    NCT06965192

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  45. Artificial Intelligence (AI)-Enhanced Pretreatment Peer-review Process to Improve Patient Safety in Radiation Oncology

    NCT07463833

    • Interventional
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: University of North Carolina at Chapel Hill, Department of Radiation Oncology (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  46. Metastatic Castrate-Resistant Prostate Cancer Subjects Treated With PROVENGE® + One Infusion of Sipuleucel-T

    NCT06134232

    • Phase 2
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Associated Urologists of North Carolina (Raleigh, NC)

    Distance to nearest recruiting site
    ~21 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  47. Sacral Neuromodulation for Male Overactive Bladder (MOAB)

    NCT06511141

    • Interventional
    • Ages 18 years and older
    • Sex: Male

    Nearest site: Associated Urologists of North Carolina (AUNC) (Raleigh, NC)

    Distance to nearest recruiting site
    ~21 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Prostate Cancer clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.