Study of AMG 509 in Participants With Metastatic Castration-Resistant Prostate Cancer
NCT04221542
This study is recruiting at 21 US sites in 17 states, according to its ClinicalTrials.gov record last updated .
Summary
The overall aim of the trial is to evaluate the safety, tolerability, and pharmacokinetics (PK) of AMG 509 (monotherapy and in combination with abiraterone acetate and enzalutamide) and to evaluate preliminary efficacy. As of Protocol Amendment 10 (09 July 2025), only Parts 4A expansion, 6, and 7 are open to accrual.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Prostate Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- Amgen
- Last updated on ClinicalTrials.gov
- August 21, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 3
- City of Hope National Medical Center · Duarte, CA
- Providence Saint Jude Medical Center · Fullerton, CA
- University of California San Francisco · San Francisco, CA
Colorado · 1
- Rocky Mountain Cancer Centers · Aurora, CO
Connecticut · 1
- Yale New Haven Hospital · New Haven, CT
Georgia · 1
- Emory University · Atlanta, GA
Indiana · 1
- Indiana University · Indianapolis, IN
Kansas · 1
- MidAmerica Cancer Care · Merriam, KS
Missouri · 1
- Washington University · St Louis, MO
New York · 1
- Memorial Sloan Kettering Cancer Center · New York, NY
North Carolina · 1
- Duke University Medical Center · Durham, NC
Ohio · 1
- Oncology Hematology Care Incorporated · Cincinnati, OH
Pennsylvania · 2
- Thomas Jefferson University · Philadelphia, PA
- University of Pittsburgh Medical Center · Pittsburgh, PA
South Dakota · 1
- Sanford Oncology Clinic and Pharmacy · Sioux Falls, SD
Tennessee · 1
- United States Oncology Regulatory Affairs Corporate Office · Nashville, TN
Texas · 2
- University of Texas MD Anderson Cancer Center · Houston, TX
- US Oncology Research Investigational Products Center · Irving, TX
Utah · 1
- Intermountain Medical Center · Murray, UT
Virginia · 1
- Virginia Cancer Specialists PC · Fairfax, VA
Washington · 1
- Fred Hutchinson Cancer Center · Seattle, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.