Testing Whether the Addition of Carboplatin Chemotherapy to Cabazitaxel Chemotherapy Will Improve Outcomes Compared to Cabazitaxel Alone in People With Castrate-Resistant Prostate Cancer That Has Spread Beyond the Prostate to Other Parts of the Body
NCT06470243
This study is recruiting at 173 US sites in 24 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effect of adding carboplatin to the standard of care chemotherapy drug cabazitaxel versus cabazitaxel alone in treating prostate cancer that keeps growing even when the amount of testosterone in the body is reduced to very low levels (castrate-resistant) and that has spread from where it first started (primary site) to other places in the body (metastatic). Carboplatin is in a class of medications known as platinum-containing compounds. Carboplatin works by killing, stopping or slowing the growth of tumor cells.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Castration-Resistant Prostate Carcinoma
- Stage IVB Prostate Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- January 22, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arkansas · 3
- Highlands Oncology Group - Fayetteville · Fayetteville, AR
- Highlands Oncology Group - Rogers · Rogers, AR
- Highlands Oncology Group · Springdale, AR
California · 1
- Tibor Rubin VA Medical Center · Long Beach, CA
Delaware · 7
- Beebe Medical Center · Lewes, DE
- Beebe South Coastal Health Campus · Millville, DE
- Christiana Care Health System-Christiana Hospital · Newark, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
- Christiana Care Health System-Wilmington Hospital · Wilmington, DE
Florida · 1
- Holy Cross Hospital · Fort Lauderdale, FL
Idaho · 7
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Idaho Urologic Institute-Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 37
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- Memorial Hospital of Carbondale · Carbondale, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Centralia Oncology Clinic · Centralia, IL
- Northwestern University · Chicago, IL
- University of Illinois · Chicago, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Crossroads Cancer Center · Effingham, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Western Illinois Cancer Treatment Center · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Methodist Medical Center of Illinois · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Valley Radiation Oncology · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- Memorial Medical Center · Springfield, IL
- Southern Illinois University School of Medicine · Springfield, IL
- Springfield Clinic · Springfield, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Illinois CancerCare - Washington · Washington, IL
Indiana · 1
- Reid Health · Richmond, IN
Iowa · 2
- Mercy Hospital · Cedar Rapids, IA
- Oncology Associates at Mercy Medical Center · Cedar Rapids, IA
Maryland · 1
- Christiana Care - Union Hospital · Elkton, MD
Michigan · 36
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Trinity Health IHA Medical Group Hematology Oncology - Brighton · Brighton, MI
- Trinity Health Medical Center - Brighton · Brighton, MI
- Trinity Health IHA Medical Group Hematology Oncology - Canton · Canton, MI
- Trinity Health Medical Center - Canton · Canton, MI
- Caro Cancer Center · Caro, MI
- Chelsea Hospital · Chelsea, MI
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital · Chelsea, MI
- Hematology Oncology Consultants-Clarkston · Clarkston, MI
- Newland Medical Associates-Clarkston · Clarkston, MI
- Henry Ford Health Saint John Hospital · Detroit, MI
- Genesee Cancer and Blood Disease Treatment Center · Flint, MI
- Genesee Hematology Oncology PC · Flint, MI
- Genesys Hurley Cancer Institute · Flint, MI
- Hurley Medical Center · Flint, MI
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Academic · Grosse Pointe Woods, MI
- Henry Ford Saint John Hospital - Breast · Grosse Pointe Woods, MI
- University of Michigan Health - Sparrow Lansing · Lansing, MI
- Trinity Health Saint Mary Mercy Livonia Hospital · Livonia, MI
- Great Lakes Cancer Management Specialists-Macomb Medical Campus · Macomb, MI
- Henry Ford Warren Hospital - Breast Macomb · Macomb, MI
- Saint Mary's Oncology/Hematology Associates of Marlette · Marlette, MI
- Hope Cancer Center · Pontiac, MI
- Michigan Healthcare Professionals Pontiac · Pontiac, MI
- Newland Medical Associates-Pontiac · Pontiac, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- MyMichigan Medical Center Saginaw · Saginaw, MI
- Oncology Hematology Associates of Saginaw Valley PC · Saginaw, MI
- MyMichigan Medical Center Tawas · Tawas City, MI
- Great Lakes Cancer Management Specialists-Macomb Professional Building · Warren, MI
- Henry Ford Madison Heights Hospital - Breast · Warren, MI
- Saint John Macomb-Oakland Hospital · Warren, MI
- Saint Mary's Oncology/Hematology Associates of West Branch · West Branch, MI
- Huron Gastroenterology PC · Ypsilanti, MI
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus · Ypsilanti, MI
Minnesota · 23
- Minnesota Oncology - Burnsville · Burnsville, MN
- Cambridge Medical Center · Cambridge, MN
- Mercy Hospital · Coon Rapids, MN
- Fairview Southdale Hospital · Edina, MN
- Fairview Clinics and Surgery Center Maple Grove · Maple Grove, MN
- Minnesota Oncology Hematology PA-Maplewood · Maplewood, MN
- Saint John's Hospital - Healtheast · Maplewood, MN
- Abbott-Northwestern Hospital · Minneapolis, MN
- Health Partners Inc · Minneapolis, MN
- Hennepin County Medical Center · Minneapolis, MN
- Monticello Cancer Center · Monticello, MN
- New Ulm Medical Center · New Ulm, MN
- Fairview Northland Medical Center · Princeton, MN
- North Memorial Medical Health Center · Robbinsdale, MN
- Park Nicollet Clinic - Saint Louis Park · Saint Louis Park, MN
- Regions Hospital · Saint Paul, MN
- United Hospital · Saint Paul, MN
- Saint Francis Regional Medical Center · Shakopee, MN
- Lakeview Hospital · Stillwater, MN
- Ridgeview Medical Center · Waconia, MN
- Rice Memorial Hospital · Willmar, MN
- Minnesota Oncology Hematology PA-Woodbury · Woodbury, MN
- Fairview Lakes Medical Center · Wyoming, MN
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
Missouri · 7
- Saint Francis Medical Center · Cape Girardeau, MO
- Southeast Cancer Center · Cape Girardeau, MO
- Parkland Health Center - Farmington · Farmington, MO
- Sainte Genevieve County Memorial Hospital · Sainte Genevieve, MO
- Missouri Baptist Medical Center · St Louis, MO
- Missouri Baptist Sullivan Hospital · Sullivan, MO
- BJC Outpatient Center at Sunset Hills · Sunset Hills, MO
Montana · 7
- Community Hospital of Anaconda · Anaconda, MT
- Billings Clinic Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Great Falls Clinic · Great Falls, MT
- Kalispell Regional Medical Center · Kalispell, MT
- Community Medical Center · Missoula, MT
Nebraska · 3
- Nebraska Medicine-Bellevue · Bellevue, NE
- Nebraska Medicine-Village Pointe · Omaha, NE
- University of Nebraska Medical Center · Omaha, NE
Ohio · 13
- Indu and Raj Soin Medical Center · Beavercreek, OH
- Saint Elizabeth Boardman Hospital · Boardman, OH
- Dayton Physicians LLC-Miami Valley South · Centerville, OH
- Oncology Hematology Care Inc-Kenwood · Cincinnati, OH
- Dayton Physician LLC - Englewood · Dayton, OH
- Armes Family Cancer Center · Findlay, OH
- Blanchard Valley Hospital · Findlay, OH
- Orion Cancer Care · Findlay, OH
- Dayton Physicians LLC-Atrium · Franklin, OH
- Dayton Physicians LLC-Wayne · Greenville, OH
- Wayne Hospital · Greenville, OH
- Greater Dayton Cancer Center · Kettering, OH
- Kettering Medical Center · Kettering, OH
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.