Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial
NCT07200830
This study is recruiting at 92 US sites in 20 states, according to its ClinicalTrials.gov record last updated .
Summary
This randomized phase III trial examines whether lengthening the dosage interval in an adaptive manner for the prostate cancer drug lutetium 177 Lu PSMA RLT improves quality of life without decreasing lifespan when compared to the standard way this medication is given. This study is for patients with hormone resistant prostate cancer that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body. Hormone resistant prostate cancer often has many cells containing a protein called prostate-specific membrane antigen (PSMA) on their surface.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Castration-Resistant Prostate Carcinoma
- Metastatic Prostate Adenocarcinoma
- Stage IVB Prostate Cancer AJCC v8
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- Male
- Healthy volunteers
- Not accepted
- Sponsor
- Alliance for Clinical Trials in Oncology
- Last updated on ClinicalTrials.gov
- October 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 8
- AIS Cancer Center at San Joaquin Community Hospital · Bakersfield, CA
- City of Hope at Irvine Lennar · Irvine, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC San Diego Moores Cancer Center · La Jolla, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- UC San Diego Medical Center - Hillcrest · San Diego, CA
Colorado · 3
- UCHealth University of Colorado Hospital · Aurora, CO
- Memorial Hospital North · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
Delaware · 2
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
Georgia · 1
- CTCA at Southeastern Regional Medical Center · Newnan, GA
Idaho · 3
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 11
- Northwestern University · Chicago, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- HSHS Saint Elizabeth's Hospital · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Northwestern Medicine Cancer Center Warrenville · Warrenville, IL
- Midwestern Regional Medical Center · Zion, IL
Iowa · 5
- Mary Greeley Medical Center · Ames, IA
- McFarland Clinic - Ames · Ames, IA
- Iowa Methodist Medical Center · Des Moines, IA
- McFarland Clinic - Trinity Cancer Center · Fort Dodge, IA
- McFarland Clinic - Marshalltown · Marshalltown, IA
Maryland · 6
- Maryland Proton Treatment Center · Baltimore, MD
- University of Maryland/Greenebaum Cancer Center · Baltimore, MD
- UM Upper Chesapeake Medical Center · Bel Air, MD
- Central Maryland Radiation Oncology in Howard County · Columbia, MD
- University of Maryland Shore Medical Center at Easton · Easton, MD
- UM Baltimore Washington Medical Center/Tate Cancer Center · Glen Burnie, MD
Michigan · 19
- Trinity Health Saint Joseph Mercy Hospital Ann Arbor · Ann Arbor, MI
- Bronson Battle Creek · Battle Creek, MI
- Henry Ford Macomb Hospital-Clinton Township · Clinton Township, MI
- Henry Ford Medical Center-Fairlane · Dearborn, MI
- Henry Ford Hospital · Detroit, MI
- Corewell Health Grand Rapids Hospitals - Butterworth Hospital · Grand Rapids, MI
- Allegiance Health · Jackson, MI
- Bronson Methodist Hospital · Kalamazoo, MI
- West Michigan Cancer Center · Kalamazoo, MI
- Corewell Health Lakeland Hospitals - Niles Hospital · Niles, MI
- Henry Ford Medical Center-Columbus · Novi, MI
- Trinity Health Saint Joseph Mercy Oakland Hospital · Pontiac, MI
- Corewell Health Reed City Hospital · Reed City, MI
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center · Saint Joseph, MI
- Corewell Health Lakeland Hospitals - Saint Joseph Hospital · Saint Joseph, MI
- Munson Medical Center · Traverse City, MI
- Henry Ford West Bloomfield Hospital · West Bloomfield, MI
- Henry Ford Wyandotte Hospital · Wyandotte, MI
- University of Michigan Health - West · Wyoming, MI
Minnesota · 1
- Coborn Cancer Center at Saint Cloud Hospital · Saint Cloud, MN
Missouri · 2
- Heartland Regional Medical Center · Saint Joseph, MO
- Missouri Baptist Medical Center · St Louis, MO
Montana · 4
- Billings Clinic Cancer Center · Billings, MT
- Bozeman Health Deaconess Hospital · Bozeman, MT
- Benefis Sletten Cancer Institute · Great Falls, MT
- Community Medical Center · Missoula, MT
New Jersey · 6
- Memorial Sloan Kettering Basking Ridge · Basking Ridge, NJ
- AtlantiCare Health Park-Cape May Court House · Cape May Court House, NJ
- AtlantiCare Surgery Center · Egg Harbor, NJ
- Memorial Sloan Kettering Monmouth · Middletown, NJ
- Memorial Sloan Kettering Bergen · Montvale, NJ
- Capital Health Medical Center-Hopewell · Pennington, NJ
New York · 7
- Roswell Park Cancer Institute · Buffalo, NY
- Memorial Sloan Kettering Commack · Commack, NY
- Memorial Sloan Kettering Westchester · Harrison, NY
- Memorial Sloan Kettering Cancer Center · New York, NY
- Montefiore Medical Center - Moses Campus · The Bronx, NY
- Montefiore Medical Center-Einstein Campus · The Bronx, NY
- Memorial Sloan Kettering Nassau · Uniondale, NY
North Dakota · 3
- Sanford Bismarck Medical Center · Bismarck, ND
- Sanford Broadway Medical Center · Fargo, ND
- Sanford Roger Maris Cancer Center · Fargo, ND
Ohio · 1
- MetroHealth Medical Center · Cleveland, OH
Oregon · 2
- Providence Portland Medical Center · Portland, OR
- Providence Saint Vincent Medical Center · Portland, OR
South Dakota · 2
- Sanford Cancer Center Oncology Clinic · Sioux Falls, SD
- Sanford USD Medical Center - Sioux Falls · Sioux Falls, SD
Texas · 1
- Covenant Medical Center-Lakeside · Lubbock, TX
Wisconsin · 5
- Froedtert Menomonee Falls Hospital · Menomonee Falls, WI
- Medical College of Wisconsin · Milwaukee, WI
- Froedtert and MCW Moorland Reserve Health Center · New Berlin, WI
- Drexel Town Square Health Center · Oak Creek, WI
- Froedtert West Bend Hospital/Kraemer Cancer Center · West Bend, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.