Heart Failure Clinical Trials Recruiting in the US
286 studies for Heart Failure are recruiting at 2,338 US sites, according to ClinicalTrials.gov data processed .
Heart failure is a long-term condition in which the heart does not pump blood as well as the body needs.
Recruiting now
Top Heart Failure studies by number of US sites
Showing 30 studies, most US recruiting sites first.
- Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
NCT06677060
- Phase 3
- Ages 40 years and older
- Sex: All
- Recruiting sites
- 167 US recruiting sites
- A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
NCT07567001
- Phase 3
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 130 US recruiting sites
- Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
NCT07037459
- Phase 3
- Ages 18 to 99 years
- Sex: All
- Recruiting sites
- 119 US recruiting sites
- Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
NCT06307652
- Phase 3
- Ages 18 to 130 years
- Sex: All
- Recruiting sites
- 104 US recruiting sites
- A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure
NCT06424288
- Phase 3
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 92 US recruiting sites
- Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
NCT00271180
- Observational
- Ages Any age
- Sex: All
- Recruiting sites
- 84 US recruiting sites
- Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
NCT06736574
- Phase 3
- Ages 18 to 85 years
- Sex: All
- Recruiting sites
- 81 US recruiting sites
- A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
NCT06008197
- Phase 3
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 79 US recruiting sites
- A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
NCT06935370
- Phase 3
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 79 US recruiting sites
- Assessment of CCM in HF With Higher Ejection Fraction
NCT05064709
- Interventional
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 75 US recruiting sites
- Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
NCT06526195
- Interventional
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 57 US recruiting sites
- A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists
NCT06033950
- Phase 3
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 54 US recruiting sites
- The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
NCT03142152
- Interventional
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 51 US recruiting sites
- Recruiting sites
- 50 US recruiting sites
- A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
NCT05489705
- Observational
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 48 US recruiting sites
- A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
NCT06024746
- Phase 3
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 46 US recruiting sites
- Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
NCT06310031
- Interventional
- Ages 18 to 100 years
- Sex: All
- Recruiting sites
- 45 US recruiting sites
- PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
NCT05934487
- Interventional
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 44 US recruiting sites
- Recruiting sites
- 42 US recruiting sites
- Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
NCT07069738
- Interventional
- Ages 18 years and older
- Sex: All
- Recruiting sites
- 40 US recruiting sites
- Recruiting sites
- 39 US recruiting sites
- AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM
NCT06378632
- Observational
- Ages 22 years and older
- Sex: All
- Recruiting sites
- 37 US recruiting sites
- Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)
NCT06898515
- Interventional
- Ages 22 years and older
- Sex: All
- Recruiting sites
- 34 US recruiting sites
- Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
NCT05677100
- Interventional
- Ages 21 years and older
- Sex: All
- Recruiting sites
- 32 US recruiting sites
- Recruiting sites
- 26 US recruiting sites
- A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
NCT06991257
- Phase 2
- Ages 18 to 79 years
- Sex: All
- Recruiting sites
- 25 US recruiting sites
- AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF
NCT06793371
- Phase 2
- Ages 40 to 85 years
- Sex: All
- Recruiting sites
- 24 US recruiting sites
- CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)
NCT05996328
- Interventional
- Ages 60 years and older
- Sex: All
- Recruiting sites
- 21 US recruiting sites
- Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
NCT05714085
- Phase 2/3
- Ages 29 days to 17 years
- Sex: All
- Recruiting sites
- 20 US recruiting sites
- A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)
NCT07219511
- Phase 1
- Ages 50 years and older
- Sex: All
- Recruiting sites
- 19 US recruiting sites
By city
Heart Failure clinical trials by city
- Ann Arbor, MI
- Atlanta, GA
- Baltimore, MD
- Bethesda, MD
- Boston, MA
- Chicago, IL
- Cincinnati, OH
- Cleveland, OH
- Dallas, TX
- Detroit, MI
- Durham, NC
- Houston, TX
- Los Angeles, CA
- Miami, FL
- New Haven, CT
- New York, NY
- Orange, CA
- Palo Alto, CA
- Philadelphia, PA
- Phoenix, AZ
- Rochester, MN
- San Diego, CA
- San Francisco, CA
- St Louis, MO
- Tampa, FL
FAQ
Common questions
What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Heart Failure clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.