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Heart Failure Clinical Trials near Orange, CA

38 studies for Heart Failure are recruiting at 96 sites within 50 miles of Orange, California, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Heart Failure trials in the US or all trials near Orange.

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Heart Failure studies enrolling near Orange

Showing 38 studies, nearest first.
  1. Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

    NCT07037459

    • Phase 3
    • Ages 18 to 99 years
    • Sex: All

    Nearest sites: University of California Irvine (Orange, CA); National Institute of Clinical Research (Huntington Beach, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    8 sites within 50 mi
  2. A Study to Evaluate Finerenone on Clinical Efficacy and Safety in Patients With Heart Failure Who Are Intolerant or Not Eligible for Treatment With Steroidal Mineralocorticoid Receptor Antagonists

    NCT06033950

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: FIN-10412, Orange, CA (Orange, CA); FIN-10070, Pamona, CA (Pomona, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    7 sites within 50 mi
  3. Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction

    NCT06736574

    • Phase 3
    • Ages 18 to 85 years
    • Sex: All

    Nearest sites: University of California, Irvine Medical Center (Orange, CA); Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center (Torrance, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    6 sites within 50 mi
  4. A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Heart Failure

    NCT06424288

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California Irvine (Orange, CA); Orange County Research Center (Tustin, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  5. AI-Enabled Direct-from-ECG Ejection Fraction (EF) Severity Assessment Using COR ECG Wearable Monitor

    NCT06699056

    • Observational
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest sites: Orange County Heart Institute (Orange, CA); Peerbridge Health (Pasadena, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  6. Fluid Management of Acute Decompensated Heart Failure Subjects Treated With Reprieve System (FASTR-II) (IDE-G210258)

    NCT06898515

    • Interventional
    • Ages 22 years and older
    • Sex: All

    Nearest sites: University of California Irvine (Irvine, CA); Memorial Care Long Beach (Long Beach, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  7. A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

    NCT07567001

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: California Heart Specialist (Huntington Beach, CA); Pacific Clinical Studies (Los Alamitos, CA)

    Distance to nearest recruiting site
    ~12 mi (city-level)
    Recruiting sites
    13 sites within 50 mi
  8. Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin

    NCT06677060

    • Phase 3
    • Ages 40 years and older
    • Sex: All

    Nearest sites: Research Site (Huntington Beach, CA); Research Site (San Dimas, CA)

    Distance to nearest recruiting site
    ~12 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  9. A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients

    NCT06008197

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Huntington Beach, CA Investigative Site 10031 (Huntington Beach, CA); Los Angeles, CA Investigative Site 10089 (Los Angeles, CA)

    Distance to nearest recruiting site
    ~12 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  10. A Safety, Tolerability, and Biomarker Trial of VS-041 in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF)

    NCT07219511

    • Phase 1
    • Ages 50 years and older
    • Sex: All

    Nearest sites: National Institute of Clinical Research (Huntington Beach, CA); Invivocure LLC (Van Nuys, CA)

    Distance to nearest recruiting site
    ~12 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  11. A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart

    NCT06935370

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Radin Cardiovascular Medical Group (Newport Beach, CA); Valley Clinical Trials, Inc. (Covina, CA)

    Distance to nearest recruiting site
    ~13 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  12. A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

    NCT06991257

    • Phase 2
    • Ages 18 to 79 years
    • Sex: All

    Nearest sites: Orange County Research Center (Lake Forest, CA); National Heart Institute (Beverly Hills, CA)

    Distance to nearest recruiting site
    ~14 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  13. CSP #2025 - Geriatric OUt-of-hospital Randomized MEal Trial in Heart Failure: Veterans Affairs (GOURMET-VA)

    NCT05996328

    • Interventional
    • Ages 60 years and older
    • Sex: All

    Nearest sites: VA Long Beach Healthcare System, Long Beach, CA (Long Beach, CA); VA Greater Los Angeles Healthcare System, West Los Angeles, CA (West Los Angeles, CA)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  14. Alleviant ALLAY-HF Study

    NCT05685303

    • Interventional
    • Ages 40 years and older
    • Sex: All

    Nearest site: Memorial Care Long Beach Medical Center (Long Beach, CA)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

    NCT06307652

    • Phase 3
    • Ages 18 to 130 years
    • Sex: All

    Nearest sites: Research Site (Covina, CA); Research Site (Los Angeles, CA)

    Distance to nearest recruiting site
    ~21 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  16. A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy

    NCT06979362

    • Phase 2
    • Ages 40 to 84 years
    • Sex: All

    Nearest sites: Valley Clinical Trials (Covina, CA); Harbor-UCLA Medical Center (Torrance, CA)

    Distance to nearest recruiting site
    ~21 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  17. A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF

    NCT07761117

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Research Site (Lomita, CA)

    Distance to nearest recruiting site
    ~27 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  18. Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure

    NCT07069738

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Torrance Medical Center (Torrance, CA); Cedars Sinai Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~28 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  19. Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products

    NCT00271180

    • Observational
    • Ages Any age
    • Sex: All

    Nearest site: (Torrance, CA)

    Distance to nearest recruiting site
    ~28 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. Assessment of CCM in HF With Higher Ejection Fraction

    NCT05064709

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Cedars Sinai Medical Center (Los Angeles, CA); USC Keck School of Medicine (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  21. The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR

    NCT03142152

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Keck School of Medicine of USC (Los Angeles, CA); UCLA Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  22. Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

    NCT05714085

    • Phase 2/3
    • Ages 29 days to 17 years
    • Sex: All

    Nearest sites: The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 0002) (Los Angeles, CA); Loma Linda University Health System ( Site 0008) (San Bernardino, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  23. Alleviant ALLAY-HFrEF Study

    NCT06812533

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Keck Medical Center of USC (Los Angeles, CA); University California Los Angeles Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  24. XVIVO Heart Box (XHB) With Supplemented XVIVO Heart Solution (SXHS) Continued Access Protocol (CAP)

    NCT06895070

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Cedars Sinai Medical Center (Los Angeles, CA); University of California Los Angeles (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  25. Transplant of Redeemed Organs by Judicious Administration of New Direct-Acting Antivirals for Hepatitis-C Heart Recipients

    NCT03383419

    • Phase 2
    • Ages 18 to 90 years
    • Sex: All

    Nearest site: Cedars-Sinai Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Women's Ischemia Syndrome Evaluation (WISE) Pre-HFpEF

    NCT03876223

    • Observational
    • Ages 18 years and older
    • Sex: All

    Nearest site: Cedars-Sinai Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. His-Bundle Corrective Pacing in Heart Failure

    NCT05265520

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Cedars-Sinai Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. The Canadian CABG or PCI in Patients With Ischemic Cardiomyopathy Trial (STICH3C)

    NCT05427370

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Cedars-Sinai (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)

    NCT05489705

    • Observational
    • Ages 18 years and older
    • Sex: All

    Nearest site: Keck School of Medicine of USC-Usc (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III

    NCT05934487

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: USC (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure

    NCT06310031

    • Interventional
    • Ages 18 to 100 years
    • Sex: All

    Nearest site: Cedars-Sinai Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. Staged Kidney Transplantation During Combined Heart/Kidney Transplantation

    NCT06877169

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Cedars-Sinai Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  33. OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

    NCT06939751

    • Observational
    • Ages 18 to 99 years
    • Sex: All

    Nearest site: Cedars-Sinai Medical Center (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. AMBER-HFpEF: Assessment of CK-4021586 in a Multi-Center, Blinded Evaluation of Safety and Tolerability Results in HFpEF

    NCT06793371

    • Phase 2
    • Ages 40 to 85 years
    • Sex: All

    Nearest site: Profound Research LLC (Pasadena, CA)

    Distance to nearest recruiting site
    ~30 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. Multi-center Trial of Ferric Derisomaltose Versus no Intravenous Iron in Iron-deficient Subjects With Symptomatic Chronic Heart Failure

    NCT06929806

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Private clinic (Pasadena, CA)

    Distance to nearest recruiting site
    ~30 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  36. A Trial of CRD-4730 in HFrEF

    NCT07750873

    • Phase 2
    • Ages 18 to 85 years
    • Sex: All

    Nearest site: Cardurion Investigative Site (Pasadena, CA)

    Distance to nearest recruiting site
    ~30 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. AN INTERNATIONAL, OBSERVATIONAL, BLINDED STUDY TO ASSESS THE PERFORMANCE OF THE CORDIO HEARO SYSTEM

    NCT06378632

    • Observational
    • Ages 22 years and older
    • Sex: All

    Nearest site: VA Loma Linda Healthcare System (Loma Linda, CA)

    Distance to nearest recruiting site
    ~38 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)

    NCT06024746

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: CON-10109, Van Nuys, CA (Van Nuys, CA)

    Distance to nearest recruiting site
    ~44 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Heart Failure clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.