Assessment of CCM in HF With Higher Ejection Fraction
NCT05064709
This study is recruiting at 75 US sites in 26 states, according to its ClinicalTrials.gov record last updated .
Summary
The AIM HIGHer Clinical Trial will evaluate the safety and efficacy of Cardiac Contractility Modulation (CCM) therapy in patients with heart failure with LVEF ≥40% and ≤70%.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Heart Failure
- Heart Failure With Preserved Ejection Fraction
- Heart Failure With Mid Range Ejection Fraction
- Heart Failure With Moderately Reduced Ejection Fraction
- Diastolic Heart Failure
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Not applicable
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Impulse Dynamics
- Last updated on ClinicalTrials.gov
- August 6, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- Grandview Medical Group Research, LLC · Birmingham, AL
Arizona · 6
- CardioVascular Associates of Mesa · Mesa, AZ
- Chan Heart Rhythm Institute · Mesa, AZ
- Southwest Cardiovascular Associates · Mesa, AZ
- Arizona Heart Rhythm · Phoenix, AZ
- Cardiovascular Consultants, Ltd · Phoenix, AZ
- HonorHealth · Scottsdale, AZ
California · 6
- John Muir Health · Concord, CA
- University of California San Diego · La Jolla, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- USC Keck School of Medicine · Los Angeles, CA
- Valley Clinical Trials- Northridge · Northridge, CA
- Sequoia Hospital · Redwood City, CA
Connecticut · 2
- Nuvance Health - Danbury Hospital · Danbury, CT
- Hartford Healthcare · Hartford, CT
Florida · 7
- HCA Florida JFK Hospital · Atlantis, FL
- Nouvelle Clinical Research LLC · Cutler Bay, FL
- Broward Health · Fort Lauderdale, FL
- Baptist Health South Florida · Miami, FL
- AdventHealth Orlando · Orlando, FL
- Revival Clinical Research · Orlando, FL
- Cleveland Clinic Foundation - Florida Weston Hospital · Weston, FL
Indiana · 1
- Ascension Medical Group St. Vincent · Indianapolis, IN
Iowa · 2
- University of Iowa · Iowa City, IA
- MercyOne Iowa Heart · West Des Moines, IA
Kansas · 2
- University of Kansas Medical Center · Kansas City, KS
- Kansas City Cardiac Arrhythmia Research LLC · Overland Park, KS
Kentucky · 1
- Baptist Health Lexington · Lexington, KY
Massachusetts · 1
- Massachusetts General Hospital · Boston, MA
Michigan · 4
- University of Michigan · Ann Arbor, MI
- Henry Ford St. John Hospital · Detroit, MI
- Ascension Providence Hospital · Southfield, MI
- Trinity health- Michigan Heart · Ypsilanti, MI
Minnesota · 1
- Minneapolis Heart Institute at Abbott Northwestern Hospital · Minneapolis, MN
Missouri · 2
- St. Louis Heart and Vascular · Bridgeton, MO
- St. Lukes Hospital Kansas City (Mid America Heart Institute) · Kansas City, MO
Nebraska · 1
- Bryan Heart · Lincoln, NE
New Jersey · 4
- Our Lady of Lourdes · Camden, NJ
- Cooper Hospital- Cardiovascular Associates of Delaware Valley · Haddon Heights, NJ
- Atlantic Health System- Morristown Medical Center · Morristown, NJ
- AtlantiCare Regional Medical Center · Pomona, NJ
New York · 3
- Buffalo General · Buffalo, NY
- Nuvance Health - Heart & Vascular Institute/Hudson Valley Cardiovascular Practice, PC · Poughkeepsie, NY
- Nuvance Health - Vassar brothers Medical Center · Poughkeepsie, NY
Ohio · 3
- Cleveland Clinic Foundation · Cleveland, OH
- Ohio State University Wexner Medical Center · Columbus, OH
- OhioHealth Research Institute · Columbus, OH
Oklahoma · 2
- Oklahoma Heart Institute · Tulsa, OK
- St. Francis Hospital - Tulsa · Tulsa, OK
Oregon · 1
- Providence Heart & Vascular · Portland, OR
Pennsylvania · 8
- Bryn Mawr Medical Specialists Association · Bryn Mawr, PA
- Penn State Hershey Medical City · Hershey, PA
- Hospital of the University of Pennsylvania · Philadelphia, PA
- Penn Presbyterian Medical Center · Philadelphia, PA
- Temple University Hospital · Philadelphia, PA
- Thomas Jefferson University Hospital · Philadelphia, PA
- Allegheny General Hospital · Pittsburgh, PA
- University of Pittsburgh Medical Center · Pittsburgh, PA
South Carolina · 1
- Prisma Health Upstate · Greenville, SC
South Dakota · 1
- North Central Heart · Sioux Falls, SD
Tennessee · 1
- The Stern Cardiovascular Foundation · Germantown, TN
Texas · 10
- Ascension Seton · Austin, TX
- Austin Heart · Austin, TX
- Baylor Scott and White Research Institute · Dallas, TX
- Baylor Scott White- All Saints- Fort Worth · Fort Worth, TX
- Medical City Fort Worth Hospital · Fort Worth, TX
- Baylor College of Medicine · Houston, TX
- Houston Methodist · Houston, TX
- Memorial Hermann Texas Medical Center · Houston, TX
- Heart Rhythm Specialists · McKinney, TX
- Baylor Scott and White Research Institute - Round Rock · Round Rock, TX
Virginia · 2
- Bon Secours St. Mary's · Richmond, VA
- Bon Secours St. Mary's · Richmond, VA
Washington · 2
- Swedish Medical Center · Seattle, WA
- Peace Health · Vancouver, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.