Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
NCT05714085
This study is recruiting at 20 US sites in 14 states, according to its ClinicalTrials.gov record last updated .
Summary
This study aims to compare the efficacy of vericiguat versus placebo on change in n-terminal pro-brain natriuretic peptide (NTproBNP) from baseline to Week 16 of the Base Period. The primary hypothesis is that vericiguat is superior to placebo in reducing NT-proBNP at Week 16 of the Base Period.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Heart Failure
- Left Ventricular Systolic Dysfunction
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2/3
- Ages
- 29 days to 17 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Merck Sharp & Dohme LLC
- Last updated on ClinicalTrials.gov
- August 28, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 3
- The Regents of the University of California - Los Angeles (UCLA Pediatrics) ( Site 0002) · Los Angeles, CA
- Lucile Packard Children's Hospital ( Site 0040) · Palo Alto, CA
- Loma Linda University Health System ( Site 0008) · San Bernardino, CA
Colorado · 1
- Children's Hospital Colorado ( Site 0012) · Aurora, CO
District of Columbia · 1
- Children's National Medical Center ( Site 0020) · Washington D.C., DC
Florida · 1
- Johns Hopkins All Children's Hospital ( Site 0029) · St. Petersburg, FL
Georgia · 1
- Children's Healthcare of Atlanta - Arthur M. Blank Hospital ( Site 0001) · Atlanta, GA
Massachusetts · 1
- Boston Children's Hospital ( Site 0035) · Boston, MA
Michigan · 1
- C.S. Mott Children's Hospital ( Site 0033) · Ann Arbor, MI
Missouri · 1
- Washington University-Pediatric Cardiology/ St. Louis Children's Hospital ( Site 0006) · St Louis, MO
New York · 2
- Columbia University Medical Center-Pediatric Cardiology ( Site 0016) · New York, NY
- The Children's Hospital at Montefiore ( Site 0030) · The Bronx, NY
Ohio · 2
- Cincinnati Children's Hospital Medical Center ( Site 0034) · Cincinnati, OH
- Cleveland Clinic-Cleveland Clinic Chidren's ( Site 0022) · Cleveland, OH
Pennsylvania · 2
- Children's Hospital of Philadelphia (CHOP) ( Site 0004) · Philadelphia, PA
- Children's Hospital of Pittsburgh ( Site 0010) · Pittsburgh, PA
Tennessee · 1
- Le Bonheur Children's Hospital ( Site 0007) · Memphis, TN
Texas · 2
- Children's Health-The Heart Center ( Site 0015) · Dallas, TX
- Texas Children's Hospital ( Site 0039) · Houston, TX
Washington · 1
- Seattle Children's Hospital-Cardiology/Fetal Therapy ( Site 0019) · Seattle, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.