Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
NCT06736574
This study is recruiting at 81 US sites in 31 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to find out if the investigational drug called omecamtiv mecarbil can reduce the risk of the effects of heart failure, like hospitalization, transplantation, or death in patients with heart failure and severely reduced ejection fraction.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Heart Failure
- Heart Failure With Reduced Ejection Fraction
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 to 85 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Cytokinetics
- Last updated on ClinicalTrials.gov
- October 13, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 2
- Advanced Cardiovascular, LLC · Alexander City, AL
- University of Alabama at Birmingham · Birmingham, AL
California · 13
- National Heart Institute · Beverly Hills, CA
- UC San Diego Health - Sulpizio Cardiovascular Center · La Jolla, CA
- Nutrition Research Center (SPH) · Loma Linda, CA
- Keck Medical Center of USC (outpatient clinic) · Los Angeles, CA
- UCLA Medical Center Cardiovascular Clinic · Los Angeles, CA
- University of California, Irvine Medical Center · Orange, CA
- Sutter Institute for Medical Research (SIMR) · Sacramento, CA
- UC Davis Health · Sacramento, CA
- San Diego Cardiac Center · San Diego, CA
- California Pacific Medical Center Van Ness Campus · San Francisco, CA
- Kaiser Permanente Santa Clara · Santa Clara, CA
- Stanford University Hospital / Stanford Health Care · Stanford, CA
- Lundquist Institute for Biomedical Innovation at Harbor - UCLA Medical Center · Torrance, CA
Colorado · 1
- Rocky Mountain Regional VA Medical Center · Aurora, CO
Connecticut · 3
- Cardiology Associates of Fairfield County, P.C · Bridgeport, CT
- Hartford Hospital · Hartford, CT
- Yale New Haven Health Heart & Vascular Center Outpatient Services · New Haven, CT
Florida · 8
- CHF Heart Clinical (Subject Visits & IP Shipments) · Clearwater, FL
- Holy Cross Medical Group - Cardiology Associates · Fort Lauderdale, FL
- South Florida Research Solutions, LLC · Hollywood, FL
- UF Health Jacksonville · Jacksonville, FL
- Broward Research Center · Miami Beach, FL
- Ocala Cardiovascular Research · Ocala, FL
- AdventHealth · Orlando, FL
- USF Health South Tampa Center for Advanced Healthcare · Tampa, FL
Georgia · 4
- Emory Clinic · Atlanta, GA
- Grady Health System · Atlanta, GA
- Piedmont Atlanta Hospital · Atlanta, GA
- Piedmont Fayette Hospital · Fayetteville, GA
Hawaii · 1
- The Queen's Medical Center - Punchbowl · Honolulu, HI
Illinois · 1
- Midwest Cardiovascular Institute · Naperville, IL
Indiana · 3
- Cardiovascular Research of Northwest Indiana, LLC. · Munster, IN
- Deaconess Heart Group · Newburgh, IN
- Reid Physician Associates · Richmond, IN
Kansas · 2
- The University of Kansas Medical Center · Kansas City, KS
- AHMG Cardiology and Surgery · Overland Park, KS
Louisiana · 1
- University Medical Center New Orleans · New Orleans, LA
Maine · 1
- Eastern Main Medical Center dba Northern Light Eastern Maine Medical Center · Bangor, ME
Maryland · 1
- University of Maryland Medical Center · Baltimore, MD
Massachusetts · 1
- Tufts Medical Center · Boston, MA
Michigan · 1
- Henry Ford Hospital · Detroit, MI
Missouri · 2
- Saint Luke's Hospital of Kansas City · Kansas City, MO
- Washington University Center for Advanced Medicine · St Louis, MO
Nebraska · 1
- University of Nebraska Medical Center · Omaha, NE
New Jersey · 2
- Advanced Heart Care, LLC · Bridgewater, NJ
- Monmouth Cardiology Associates, LLC · Eatontown, NJ
New York · 5
- Capital Cardiology Associates · Albany, NY
- Northwell Health North Shore University Hospital · Manhasset, NY
- Columbia University Medical Center / New York - Presbyterian · New York, NY
- Mount Sinai Hospital · New York, NY
- Montefiore Medical Center (Moses Campus) · The Bronx, NY
North Carolina · 5
- WakeMed Heart & Vascular - Cary Cardiology · Cary, NC
- Clinical and Translational Research Center - University of North Carolina at Chapel Hill · Chapel Hill, NC
- Duke University Hospital · Durham, NC
- Moses H. Cone Memorial Hospital Operating Corporation d/b/a Cone Health · Greensboro, NC
- Wake Forest University Health Sciences · Winston-Salem, NC
Ohio · 3
- The Lindner Research Center at the Christ Hospital · Cincinnati, OH
- Cleveland Clinic · Cleveland, OH
- University Hospitals Cleveland Medical Center · Cleveland, OH
Oklahoma · 1
- Oklahoma State University Center for Health Sciences · Tulsa, OK
Oregon · 1
- Oregon Health and Science University · Portland, OR
Pennsylvania · 3
- Capital Area Research, LLC · Camp Hill, PA
- Penn State Health Milton S. Hershey Medical Center · Hershey, PA
- Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine) · Philadelphia, PA
South Carolina · 1
- Medical University of South Carolina - Gazes Research Institute · Charleston, SC
South Dakota · 1
- Monument Health Clinical Research, a department of Monument Health Rapid City Hospital, Inc. · Rapid City, SD
Tennessee · 4
- Stern Cardiovascular Foundation, Inc. · Germantown, TN
- Tennova Healthcare-Turkey Creek Medical Center · Knoxville, TN
- Vanderbilt University Medical Center · Nashville, TN
- Tennessee Center for Clinical Trials · Tullahoma, TN
Texas · 5
- Baylor University Medical Center · Dallas, TX
- The University of Texas Southwestern Medical Center · Dallas, TX
- University of Texas Medical Branch - UTMB · Galveston, TX
- CHI St. Luke's Health Baylor College of Medicine Medical Center · Houston, TX
- Baylor Scott & White Medical Center- The Hearth Hospital · Plano, TX
Utah · 2
- Intermountain Medical Center · Murray, UT
- University of Utah Health · Salt Lake City, UT
Washington · 1
- Providence Advanced Heart Disease and Transplant · Spokane, WA
Wisconsin · 1
- Medical College of Wisconsin / Froedtert Hospital · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.