Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
NCT05677100
This study is recruiting at 32 US sites in 16 states, according to its ClinicalTrials.gov record last updated .
Summary
Aortix is a circulatory support device for chronic heart failure patients on medical management who have been hospitalized for acute decompensated heart failure (ADHF) and have persistent congestion despite usual medical therapy. Eligible ADHF patients with diuretic resistance (irrespective of ejection fraction) will be enrolled and randomized 1:1 to either the Aortix system or standard of care medical management.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Heart Failure
- Cardiorenal Syndrome
- Cardio-Renal Syndrome
- ADHF
- Heart Failure, Systolic
- Heart Failure, Diastolic
- Heart Failure; With Decompensation
- Heart Failure, Congestive
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Not applicable
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Procyrion
- Last updated on ClinicalTrials.gov
- August 25, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Banner--University Medical Center Phoenix · Phoenix, AZ
- Mayo Clinic - Arizona · Phoenix, AZ
California · 3
- John Muir Health · Concord, CA
- University of California San Francisco · San Francisco, CA
- Zuckerberg San Francisco General · San Francisco, CA
Florida · 5
- Broward Health · Fort Lauderdale, FL
- AdventHealth Tampa · Tampa, FL
- BayCare Medical/St. Joseph's Hospital · Tampa, FL
- University of South Florida · Tampa, FL
- Cleveland Clinic Florida · Weston, FL
Georgia · 2
- Emory University Hospital · Atlanta, GA
- Piedmont Healthcare Inc. · Augusta, GA
Illinois · 3
- Advocate IMMC · Chicago, IL
- University of Chicago · Chicago, IL
- Ascenscion Alexian Brothers · Elk Grove Village, IL
Michigan · 1
- Henry Ford · Detroit, MI
Mississippi · 1
- University of Mississippi Medical Center · Jackson, MS
New Jersey · 2
- Hackensack University Medical Center · Hackensack, NJ
- Jersey Shore University Medical Center · Neptune City, NJ
New York · 5
- New York Presbyterian - Brooklyn Methodist Hospital · Brooklyn, NY
- Mount Sinai Morningside · New York, NY
- Nyph/Cumc · New York, NY
- Nuvance Health · Poughkeepsie, NY
- Northwell Health (Staten Island) · Staten Island, NY
North Carolina · 1
- Atrium Health Sanger Heart and Vascular Institute · Charlotte, NC
Ohio · 1
- The Ohio State University · Columbus, OH
Oklahoma · 1
- Oklahoma Cardiovascular Research Group · Oklahoma City, OK
Pennsylvania · 2
- Jefferson Abington Hospital · Abington, PA
- Penn Presbyterian Medical Center · Philadelphia, PA
South Carolina · 1
- AnMed Health · Anderson, SC
Texas · 1
- Texas Heart Institute · Houston, TX
Virginia · 1
- Virginia Commonwealth University · Richmond, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.