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Breast Cancer Clinical Trials near Orange, CA

179 studies for Breast Cancer are recruiting at 496 sites within 50 miles of Orange, California, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Breast Cancer trials in the US or all trials near Orange.

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Recruiting now

Breast Cancer studies enrolling near Orange

Showing the 50 nearest of 179 studies.
  1. Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

    NCT05879926

    • Phase 3
    • Ages 18 to 60 years
    • Sex: Female

    Nearest sites: UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA); Kaiser Permanente-Anaheim (Anaheim, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    25 sites within 50 mi
  2. Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

    NCT06058377

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA); UCI Health - Yorba Linda (Yorba Linda, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    18 sites within 50 mi
  3. E-Mindfulness Approaches for Living After Breast Cancer

    NCT06748222

    • Phase 3
    • Ages 18 to 50 years
    • Sex: All

    Nearest sites: UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA); Kaiser Permanente-Anaheim (Anaheim, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    17 sites within 50 mi
  4. De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

    NCT04852887

    • Phase 3
    • Ages 50 to 70 years
    • Sex: All

    Nearest sites: Saint Joseph Hospital - Orange (Orange, CA); UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    13 sites within 50 mi
  5. A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

    NCT06492616

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health, Chao Family Comprehensive Cancer Center (Orange, CA); City of Hope at Irvine Lennar (Irvine, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    10 sites within 50 mi
  6. ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

    NCT06876714

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA); UCI Health - Yorba Linda (Yorba Linda, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    9 sites within 50 mi
  7. Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

    NCT05812807

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Saint Joseph Hospital - Orange (Orange, CA); Torrance Memorial Physician Network - Cancer Care (Torrance, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    8 sites within 50 mi
  8. Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

    NCT07391774

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA); UCI Health - Yorba Linda (Yorba Linda, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    6 sites within 50 mi
  9. Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

    NCT05564377

    • Phase 2
    • Ages Any age
    • Sex: All

    Nearest sites: Children's Hospital of Orange County (Orange, CA); Saint Joseph Hospital - Orange (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  10. Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

    NCT05827081

    • Phase 3
    • Ages 18 to 100 years
    • Sex: All

    Nearest sites: UC Irvine Medical Center (Orange, CA); Providence Medical Foundation (Fullerton, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  11. Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread

    NCT06324357

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California Irvine (Orange, CA); The Oncology Institute of Hope and Innovation (Cerritos, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  12. Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

    NCT05983432

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California Irvine Medical Center (Orange, CA); City of Hope Cancer Center (Duarte, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  13. SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    NCT03452774

    • Observational
    • Ages Any age
    • Sex: All

    Nearest sites: Massive Bio SYNERGY-AI site (Orange, CA); Massive Bio SYNERGY-AI site (Irvine, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  14. A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

    NCT05208762

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health - Chao Family Comprehensive Cancer Center (Orange, CA); Chao Family Comprehensive Cancer Center and Ambulatory Care (Irvine, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  15. A Study of Emiltatug Ledadotin (Emi-Le) in Participants With Solid Tumors

    NCT05377996

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health-Chao Family Comprehensive Cancer Center (Orange, CA); UCLA David Geffen School of Medicine, Division of Hematology/Oncology (Santa Monica, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  16. ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

    NCT07007559

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health - Chao Family Comprehensive Cancer Center (Orange, CA); City of Hope (Duarte, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  17. A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

    NCT07054190

    • Phase 2
    • Ages 18 years and older
    • Sex: Female

    Nearest sites: Community Clinical Trials (Orange, CA); Los Angeles Cancer Network (Los Angeles, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  18. Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer

    NCT05524584

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center, University of California, Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

    NCT06580002

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center, University of California Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

    NCT07064018

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center University of California, Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

    NCT07447050

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center, University of California Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

    NCT05929768

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Kaiser Permanente-Anaheim (Anaheim, CA); City of Hope at Irvine Lennar (Irvine, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    25 sites within 50 mi
  23. Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

    NCT06072612

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Los Angeles cancer Network_Anaheim (Anaheim, CA); Los Angeles cancer Network_Fountain Vallley (Fountain Valley, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    21 sites within 50 mi
  24. S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

    NCT03723928

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Kaiser Permanente-Anaheim (Anaheim, CA); Kaiser Permanente-Irvine (Irvine, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    11 sites within 50 mi
  25. A Study of Sigvotatug Vedotin in Advanced Solid Tumors

    NCT04389632

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Anaheim, CA); Providence Medical Foundation (Fullerton, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    7 sites within 50 mi
  26. Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. Trastuzumab Deruxtecan Alone or in Combination With Anastrozole for the Treatment of Early Stage HER2 Low, Hormone Receptor Positive Breast Cancer

    NCT04553770

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: St. Joseph Heritage Healthcare (Fullerton, CA); Cancer Blood and Specialty Clinic (Los Alamitos, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  28. Phase 3 Study to Evaluate the Efficacy and Safety of HER2/Neu Peptide GLSI-100 (GP2 + GM-CSF) in HER2/Neu Positive Subjects

    NCT05232916

    • Phase 3
    • Ages 18 to 100 years
    • Sex: All

    Nearest sites: Providence St. Jude Medical Center - Virginia K. Crosson Cancer Center (Fullerton, CA); City of Hope - Orange County Lennar Foundation Cancer Center (Irvine, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  29. A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

    NCT06966700

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation ( Site 0080) (Fullerton, CA); Hoag Memorial Hospital Presbyterian ( Site 0010) (Newport Beach, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  30. Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

    NCT05297734

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: St Jude Heritage Medical Group (Fullerton, CA); Beckman Research Institute of City of Hope (Duarte, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  31. Study of Abemaciclib and Elacestrant in Participants With Brain Metastasis Due to ER+/HER-2- Breast Cancer

    NCT05386108

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Fullerton, CA); California Research Institute (Los Angeles, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  32. Phase 3 Study of Gedatolisib as First-Line Treatment for Patients With HR-Positive, HER2-Negative Advanced Breast Cancer (VIKTORIA-2)

    NCT06757634

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Fullerton, CA); UCLA Hematology Oncology Santa Monica (Los Angeles, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  33. A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

    NCT06997029

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence St. Jude Medical Center (Fullerton, CA); Hoag Memorial Hospital Presbyterian (Newport Beach, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  34. Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. A Study of Alisertib in Combination With Endocrine Therapy in Patients With HR-positive, HER2-negative Recurrent or Metastatic Breast Cancer

    NCT06369285

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: MemorialCare Orange Coast Medical Center (Fountain Valley, CA); City of Hope at Orange County Lennar Foundation Cancer Center (Irvine, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  36. Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  37. Sacituzumab Tirumotecan (MK-2870) Plus Pembrolizumab Versus TPC in TNBC Who Did Not Achieve pCR (MK-2870-012)

    NCT06393374

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: MemorialCare Orange Coast Medical Center ( Site 9501) (Fountain Valley, CA); Profound Research LLC ( Site 0105) (Oceanside, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  38. BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

    NCT07492641

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Helios Clinical Research the Oncology Institute Fountain Valley (Fountain Valley, CA); California Research Institute (Los Angeles, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  39. Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. A Blended e-Health Intervention to Improve Fear of Progression in Women With Gynecologic or Breast Cancer

    NCT07741968

    • Interventional
    • Ages 18 years and older
    • Sex: Female

    Nearest sites: City of Hope at Irvine Lennar (Irvine, CA); City of Hope at Seacliff (Huntington Beach, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    8 sites within 50 mi
  41. Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  42. A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

    NCT06790693

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: City of Hope - Lennar Foundation Cancer Center (Irvine, CA); Cancer and Blood Specialty Clinic (Los Alamitos, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  43. Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

    NCT04305834

    • Phase 2
    • Ages 70 years and older
    • Sex: All

    Nearest sites: City of Hope at Irvine Lennar (Irvine, CA); City of Hope at Long Beach Elm (Long Beach, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  44. Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

    NCT05315700

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: City of Hope (Irvine, CA); City of Hope (Huntington Beach, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  45. A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

    NCT03424005

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: City of Hope - Orange County Lennar Foundation Cancer Center (Irvine, CA); City of Hope - Duarte (Duarte, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  46. A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

    NCT04802759

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Female

    Nearest sites: City of Hope - Orange County Lennar Foundation Cancer Center (Irvine, CA); City of Hope (Duarte, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  47. Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

    NCT05005403

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: City of Hope - Orange County Lennar Foundation Cancer Center /ID# 278589 (Irvine, CA); City of Hope National Medical Center /ID# 276272 (Duarte, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  48. A Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) as Monotherapy and in Combination With Pembrolizumab (MK-3475) in Participants With Triple-Negative Breast Cancer (MK-2870-011/TroFuse-011)

    NCT06841354

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: City of Hope Lennar Foundation Cancer Center ( Site 0099) (Irvine, CA); City of Hope ( Site 0097) (Duarte, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  49. A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

    NCT07174336

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: City of Hope Orange County Lennar Foundation Cancer Center (Irvine, CA); City of Hope (Duarte, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  50. Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

    NCT02620852

    • Interventional
    • Ages 30 to 74 years
    • Sex: Female
    • Accepts healthy volunteers

    Nearest sites: University of California Irvine (Irvine, CA); University of California Los Angeles (Los Angeles, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    2 sites within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Breast Cancer clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.