Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer
NCT05929768
This study is recruiting at 913 US sites in 48 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Anatomic Stage I Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage IIIA Breast Cancer AJCC v8
- Anatomic Stage IIIB Breast Cancer AJCC v8
- Early Stage Triple-Negative Breast Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- SWOG Cancer Research Network
- Last updated on ClinicalTrials.gov
- November 5, 2025
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Alaska · 7
- Alaska Breast Care and Surgery LLC · Anchorage, AK
- Alaska Oncology and Hematology LLC · Anchorage, AK
- Alaska Women's Cancer Care · Anchorage, AK
- Anchorage Associates in Radiation Medicine · Anchorage, AK
- Katmai Oncology Group · Anchorage, AK
- Providence Alaska Medical Center · Anchorage, AK
- Fairbanks Memorial Hospital · Fairbanks, AK
Arizona · 2
- Kingman Regional Medical Center · Kingman, AZ
- Cancer Center at Saint Joseph's · Phoenix, AZ
Arkansas · 7
- Highlands Oncology Group - Fayetteville · Fayetteville, AR
- Mercy Hospital Fort Smith · Fort Smith, AR
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro · Jonesboro, AR
- CARTI Cancer Center · Little Rock, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
- Highlands Oncology Group - Rogers · Rogers, AR
- Highlands Oncology Group · Springdale, AR
California · 75
- Kaiser Permanente-Anaheim · Anaheim, CA
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- PCR Oncology · Arroyo Grande, CA
- Sutter Auburn Faith Hospital · Auburn, CA
- Sutter Cancer Centers Radiation Oncology Services-Auburn · Auburn, CA
- Kaiser Permanente-Baldwin Park · Baldwin Park, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- Providence Saint Joseph Medical Center/Disney Family Cancer Center · Burbank, CA
- Mills-Peninsula Medical Center · Burlingame, CA
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park · Cameron Park, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Eden Hospital Medical Center · Castro Valley, CA
- Sutter Davis Hospital · Davis, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Stanford Cancer Center Emeryville · Emeryville, CA
- Kaiser Permanente-Fontana · Fontana, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- Kaiser Permanente South Bay · Harbor City, CA
- City of Hope at Irvine Lennar · Irvine, CA
- Kaiser Permanente-Irvine · Irvine, CA
- City of Hope Antelope Valley · Lancaster, CA
- Loma Linda University Medical Center · Loma Linda, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Kaiser Permanente West Los Angeles · Los Angeles, CA
- Contra Costa Regional Medical Center · Martinez, CA
- Mercy Cancer Center · Merced, CA
- Memorial Medical Center · Modesto, CA
- Palo Alto Medical Foundation-Camino Division · Mountain View, CA
- Palo Alto Medical Foundation-Gynecologic Oncology · Mountain View, CA
- Providence Queen of The Valley · Napa, CA
- City of Hope Newport Beach · Newport Beach, CA
- Sutter Cancer Research Consortium · Novato, CA
- Kaiser Permanente-Ontario · Ontario, CA
- Desert Regional Medical Center · Palm Springs, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Stanford Cancer Institute Palo Alto · Palo Alto, CA
- Kaiser Permanente - Panorama City · Panorama City, CA
- Huntington Memorial Hospital · Pasadena, CA
- Kaiser Permanente-Riverside · Riverside, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Sutter Cancer Centers Radiation Oncology Services-Roseville · Roseville, CA
- Sutter Roseville Medical Center · Roseville, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- Salinas Valley Memorial · Salinas, CA
- Kaiser Permanente-San Diego Zion · San Diego, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Stanford Cancer Center South Bay · San Jose, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Kaiser Permanente-San Marcos · San Marcos, CA
- Mills Health Center · San Mateo, CA
- Ridley-Tree Cancer Center · Santa Barbara, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Santa Cruz Radiation Oncology Medical Group · Santa Cruz, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Saint John's Cancer Institute · Santa Monica, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Providence Santa Rosa Memorial Hospital · Santa Rosa, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- City of Hope South Pasadena · South Pasadena, CA
- Saint Joseph's Medical Center · Stockton, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- City of Hope South Bay · Torrance, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- City of Hope Upland · Upland, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
- BASS Medical Group - Lennon · Walnut Creek, CA
- Woodland Memorial Hospital · Woodland, CA
- Kaiser Permanente-Woodland Hills · Woodland Hills, CA
Colorado · 44
- Rocky Mountain Cancer Centers-Aurora · Aurora, CO
- Boulder Community Foothills Hospital · Boulder, CO
- Rocky Mountain Cancer Centers-Boulder · Boulder, CO
- Intermountain Health Platte Valley Hospital · Brighton, CO
- Rocky Mountain Cancer Centers - Centennial · Centennial, CO
- Memorial Hospital North · Colorado Springs, CO
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Rocky Mountain Cancer Centers-Penrose · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- AdventHealth Porter · Denver, CO
- Cancer Center of Colorado at Sloan's Lake · Denver, CO
- Colorado Blood Cancer Institute · Denver, CO
- National Jewish Health-Main Campus · Denver, CO
- Presbyterian - Saint Lukes Medical Center - Health One · Denver, CO
- Rocky Mountain Cancer Centers-Midtown · Denver, CO
- Rocky Mountain Cancer Centers-Rose · Denver, CO
- Saint Joseph Hospital - Cancer Centers of Colorado · Denver, CO
- The Women's Imaging Center · Denver, CO
- CommonSpirit Cancer Center Mercy · Durango, CO
- Mercy Medical Center · Durango, CO
- Rocky Mountain Cancer Centers - Swedish · Englewood, CO
- The Melanoma and Skin Cancer Institute · Englewood, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- Lutheran Hospital - Cancer Centers of Colorado · Golden, CO
- National Jewish Health-Western Hematology Oncology · Golden, CO
- Saint Mary's Hospital and Regional Medical Center · Grand Junction, CO
- UCHealth Greeley Hospital · Greeley, CO
- Good Samaritan Hospital - Cancer Centers of Colorado · Lafayette, CO
- Rocky Mountain Cancer Centers-Lakewood · Lakewood, CO
- Saint Anthony Hospital · Lakewood, CO
- AdventHealth Littleton · Littleton, CO
- Rocky Mountain Cancer Centers-Littleton · Littleton, CO
- Rocky Mountain Cancer Centers-Sky Ridge · Lone Tree, CO
- Longmont United Hospital · Longmont, CO
- Rocky Mountain Cancer Centers-Longmont · Longmont, CO
- Medical Center of the Rockies · Loveland, CO
- AdventHealth Parker · Parker, CO
- Saint Mary Corwin Medical Center · Pueblo, CO
- National Jewish Health-Northern Hematology Oncology · Thornton, CO
- Rocky Mountain Cancer Centers-Thornton · Thornton, CO
- Saint Anthony North Hospital · Westminster, CO
- Intermountain Health Lutheran Hospital · Wheat Ridge, CO
Connecticut · 14
- Hartford HealthCare - Avon · Avon, CT
- Hartford HealthCare - Saint Vincent's Medical Center · Bridgeport, CT
- Danbury Hospital · Danbury, CT
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Hartford Healthcare - Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Hartford Hospital · Hartford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Hartford HealthCare - Manchester · Manchester, CT
- Midstate Medical Center · Meriden, CT
- The Hospital of Central Connecticut · New Britain, CT
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.