A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)
NCT06312176
This study is recruiting at 37 US sites in 19 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to compare sacituzumab tirumotecan as a single agent, and in combination with pembrolizumab, versus Treatment of Physician's Choice (TPC) in participants with hormone receptor positive/human epidermal growth factor receptor-2 negative (HR+/HER2-) unresectable locally advanced, or metastatic, breast cancer.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Breast Neoplasms
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Merck Sharp & Dohme LLC
- Last updated on ClinicalTrials.gov
- October 13, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Ironwood Cancer & Research Centers ( Site 0066) · Chandler, AZ
- Banner MD Anderson Cancer Center-Oncology ( Site 0004) · Gilbert, AZ
California · 1
- Providence Medical Foundation-Oncology ( Site 0020) · Fullerton, CA
Colorado · 2
- University of Colorado Anschutz Medical Campus ( Site 0061) · Aurora, CO
- UCHealth Cherry Creek Medical Center ( Site 0094) · Denver, CO
Connecticut · 1
- Stamford Hospital ( Site 0049) · Stamford, CT
Florida · 2
- AdventHealth Altamonte Springs ( Site 0021) · Altamonte Springs, FL
- Orlando Health Cancer Institute ( Site 0011) · Orlando, FL
Illinois · 1
- Rush University Medical Center ( Site 0079) · Chicago, IL
Kentucky · 1
- Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0053) · Edgewood, KY
Louisiana · 1
- Mary Bird Perkins Cancer Center-Breast & GYN Pavilion ( Site 0042) · Baton Rouge, LA
Maryland · 2
- Greenebaum Comprehensive Cancer Center ( Site 0036) · Baltimore, MD
- Holy Cross Hospital ( Site 0073) · Silver Spring, MD
Massachusetts · 1
- Dana-Farber Cancer Institute-Breast Oncology Center ( Site 0037) · Boston, MA
Michigan · 1
- Henry Ford Health ( Site 0002) · Detroit, MI
Missouri · 2
- Saint Luke's Cancer Institute ( Site 0027) · Kansas City, MO
- Washington University School of Medicine ( Site 0076) · St Louis, MO
New York · 5
- NYU Langone Health - Brooklyn ( Site 0089) · Brooklyn, NY
- NYU Langone Hospital - Long Island ( Site 0090) · Mineola, NY
- Laura and Isaac Perlmutter Cancer Center-Hematology and Oncology ( Site 0068) · New York, NY
- Hematology Oncology Associates of Rockland ( Site 0054) · Nyack, NY
- Stony Brook University-Cancer Center ( Site 0034) · Stony Brook, NY
North Carolina · 1
- Levine Cancer Institute ( Site 0014) · Charlotte, NC
Oregon · 2
- Providence Portland Medical Center ( Site 0044) · Portland, OR
- Providence St. Vincent Medical Center ( Site 0081) · Portland, OR
Pennsylvania · 1
- Thomas Jefferson University - Clinical Research Institute ( Site 0056) · Philadelphia, PA
Texas · 6
- Parkland Health and Hospital System ( Site 0069) · Dallas, TX
- Texas Oncology-Dallas Presbyterian Hospital ( Site 8000) · Dallas, TX
- UT Southwestern Medical Center ( Site 0050) · Dallas, TX
- The Center for Cancer and Blood Disorders ( Site 0041) · Fort Worth, TX
- Texas Oncology - San Antonio ( Site 8002) · San Antonio, TX
- The University of Texas Health Science Center at Tyler dba UT Health East Texas HOPE Cancer Center ( Site 0057) · Tyler, TX
Virginia · 4
- Inova Schar Cancer Institute ( Site 0025) · Fairfax, VA
- Bon Secours St. Francis Medical Center-Oncology Research ( Site 0015) · Midlothian, VA
- VCU Health Adult Outpatient Pavillion ( Site 0070) · Richmond, VA
- Oncology and Hematology Associates of Southwest Virginia (BRCC) ( Site 8001) · Roanoke, VA
Wisconsin · 1
- University Hospital and UW Health Clinics-Carbone Cancer Center ( Site 0040) · Madison, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.