Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer
NCT06380751
This study is recruiting at 35 US sites in 18 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary objective of the study is to measure efficacy of saruparib (AZD5305) plus camizestrant compared with physician's choice CDK4/6i plus ET in patients with BRCA1, BRCA2, or PALB2m, HR-positive, HER2-negative (defined as IHC 0, 1+, 2+/ ISH non-amplified) advanced breast cancer
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Advanced Breast Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- AstraZeneca
- Last updated on ClinicalTrials.gov
- September 2, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- Research Site · Gilbert, AZ
California · 4
- Research Site · Fountain Valley, CA
- Research Site · Glendale, CA
- Research Site · Los Angeles, CA
- Research Site · Newport Beach, CA
Colorado · 1
- Research Site · Aurora, CO
Florida · 2
- Research Site · Hollywood, FL
- Research Site · Jacksonville, FL
Illinois · 5
- Research Site · Arlington Heights, IL
- Research Site · Chicago, IL
- Research Site · Evanston, IL
- Research Site · Urbana, IL
- Research Site · Winfield, IL
Maryland · 1
- Research Site · Silver Spring, MD
Massachusetts · 1
- Research Site · Boston, MA
Michigan · 1
- Research Site · Royal Oak, MI
Minnesota · 1
- Research Site · Rochester, MN
Missouri · 2
- Research Site · Saint Joseph, MO
- Research Site · Springfield, MO
New Jersey · 1
- Research Site · Camden, NJ
New York · 4
- Research Site · Mineola, NY
- Research Site · New York, NY
- Research Site · New York, NY
- Research Site · Stony Brook, NY
Pennsylvania · 3
- Research Site · Hershey, PA
- Research Site · Philadelphia, PA
- Research Site · Pittsburgh, PA
Tennessee · 2
- Research Site · Chattanooga, TN
- Research Site · Nashville, TN
Texas · 3
- Research Site · Houston, TX
- Research Site · Houston, TX
- Research Site · San Antonio, TX
Virginia · 1
- Research Site · Norfolk, VA
Washington · 1
- Research Site · Tacoma, WA
West Virginia · 1
- Research Site · Morgantown, WV
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.