A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer
NCT03424005
This study is recruiting at 14 US sites in 8 states, according to its ClinicalTrials.gov record last updated .
Summary
This is an umbrella study evaluating the efficacy and safety of multiple treatment combinations in participants with metastatic or inoperable locally advanced breast cancer. The study will be performed in two stages. During Stage 1, seven cohorts will be enrolled in parallel in this study: Cohort 1 will consist of programmed death-ligand 1 (PD-L1)-positive participants who have received no prior systemic therapy for metastatic or inoperable locally advanced triple-negative breast cancer (TNBC) (first-line [1L] PD-L1+ cohort).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Metastatic Breast Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1/2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Hoffmann-La Roche
- Last updated on ClinicalTrials.gov
- October 9, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 4
- City of Hope - Duarte · Duarte, CA
- City of Hope - Orange County Lennar Foundation Cancer Center · Irvine, CA
- University of California San Diego (UCSD) - Koman Family Outpatient Pavilion ? La Jolla · La Jolla, CA
- UCLA Health 200 Medical Plaza · Los Angeles, CA
Illinois · 1
- City of Hope® Cancer Center Chicago · Zion, IL
Minnesota · 1
- Metro-Minnesota Community Oncology Research Consortium · Saint Paul, MN
Nebraska · 1
- Nebraska Cancer Specialists - Midwest Cancer Center - Legacy · Omaha, NE
Nevada · 1
- Renown Regional Medical Center · Reno, NV
North Carolina · 1
- Duke Cancer Institute · Durham, NC
Ohio · 1
- The Ohio State University Comprehensive Cancer Center · Columbus, OH
Tennessee · 4
- Tennessee Oncology - Chattanooga Oncology & Hematology Associates · Chattanooga, TN
- The West Clinic · Germantown, TN
- Tennessee Oncology PLLC · Nashville, TN
- Vanderbilt University Medical Center · Nashville, TN
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.