A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
NCT07174336
This study is recruiting at 51 US sites in 20 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of the study is to assess the efficacy and safety of the addition of Tersolisib (LY4064809/STX-478) to other anti-cancer drugs as first treatment for advanced hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) breast cancer. Participants can remain in the study as long as the drug is helping the cancer without unbearable side effects.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Breast Neoplasms
- Neoplasm Metastasis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Eli Lilly and Company
- Last updated on ClinicalTrials.gov
- October 8, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Ironwood Cancer & Research Centers · Chandler, AZ
- The University of Arizona Cancer Center - North Campus · Tucson, AZ
Arkansas · 1
- Highlands Oncology Group · Springdale, AR
California · 6
- City of Hope · Duarte, CA
- Epic Care - Emeryville · Emeryville, CA
- Marin Cancer Care · Greenbrae, CA
- City of Hope Orange County Lennar Foundation Cancer Center · Irvine, CA
- Profound Research LLC · Oceanside, CA
- Providence Medical Foundation · Santa Rosa, CA
District of Columbia · 1
- MedStar Washington Hospital Center · Washington D.C., DC
Florida · 3
- Clermont Oncology Center · Clermont, FL
- Florida Oncology & Hematology · Fort Myers, FL
- Mid Florida Hematology and Oncology Center · Orange City, FL
Georgia · 3
- Central Georgia Cancer Care · Macon, GA
- City of Hope National Medical Center, Atlanta Cancer Center · Newnan, GA
- Summit Cancer Care, PC · Savannah, GA
Illinois · 2
- City of Hope, Chicago · Chicago, IL
- Accellacare of Duly · Lisle, IL
Indiana · 1
- Indiana University Health University Hospital · Indianapolis, IN
Kentucky · 1
- Saint Elizabeth Medical Center Edgewood · Edgewood, KY
Maryland · 2
- American Oncology Partners, PA · Bethesda, MD
- James M Stockman Cancer Institute · Frederick, MD
Mississippi · 1
- North Mississippi Hematology and Oncology Associates · Tupelo, MS
Missouri · 1
- Oncology Hematology Associates · Springfield, MO
New Jersey · 3
- Jefferson Health - Cherry Hill · Cherry Hill, NJ
- Sidney Kimmel Cancer Center - Washington Township · Sewell, NJ
- Atlantic Health System Overlook Medical Center · Summit, NJ
North Carolina · 2
- Messino Cancer Centers · Asheville, NC
- Carolina Cancer Research Center · Wilson, NC
Oregon · 2
- Good Samaritan Regional Medical Center · Corvallis, OR
- Oncology Associates of Oregon · Eugene, OR
Pennsylvania · 4
- St. Luke's University Health Network · Bethlehem, PA
- Jefferson Hospital Northeast · Philadelphia, PA
- Thomas Jefferson University - Clinical Research Institute · Philadelphia, PA
- Asplundh Cancer Pavilion · Willow Grove, PA
Tennessee · 2
- Nashville General Hospital · Nashville, TN
- Sarah Cannon Research Institute SCRI · Nashville, TN
Texas · 9
- World Research Link · Baytown, TX
- USO - Texas Oncology · Dallas, TX
- UT Southwestern Medical Center · Dallas, TX
- Texas Oncology - West Texas · El Paso, TX
- Oncology Consultants P.A. · Houston, TX
- Nova Oncology · McAllen, TX
- Texas Oncology - San Antonio Medical Center · San Antonio, TX
- US Oncology Research Network · The Woodlands, TX
- Tranquility Research · Webster, TX
Washington · 4
- UW Medicine Valley Medical Center · Renton, WA
- Deaconess Hospital · Spokane, WA
- MultiCare Health System · Tacoma, WA
- North Star Lodge · Yakima, WA
Wisconsin · 1
- ThedaCare Physicians - Appleton North · Appleton, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.