De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)
NCT04852887
This study is recruiting at 704 US sites in 46 states, according to its ClinicalTrials.gov record last updated .
Summary
This Phase III Trial evaluates whether breast conservation surgery and endocrine therapy results in a non-inferior rate of invasive or non-invasive ipsilateral breast tumor recurrence (IBTR) compared to breast conservation with breast radiation and endocrine therapy.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Stage I Breast Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 50 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- NRG Oncology
- Last updated on ClinicalTrials.gov
- April 23, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of South Alabama Mitchell Cancer Institute · Mobile, AL
Arizona · 2
- Kingman Regional Medical Center · Kingman, AZ
- Cancer Center at Saint Joseph's · Phoenix, AZ
Arkansas · 1
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 78
- Kaiser Permanente-Anaheim · Anaheim, CA
- Kaiser Permanente-Deer Valley Medical Center · Antioch, CA
- Mission Hope Medical Oncology - Arroyo Grande · Arroyo Grande, CA
- PCR Oncology · Arroyo Grande, CA
- Sutter Auburn Faith Hospital · Auburn, CA
- Sutter Cancer Centers Radiation Oncology Services-Auburn · Auburn, CA
- Kaiser Permanente-Bellflower · Bellflower, CA
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Mercy Cancer Center - Carmichael · Carmichael, CA
- Mercy San Juan Medical Center · Carmichael, CA
- Kaiser Permanente Dublin · Dublin, CA
- Mercy Cancer Center - Elk Grove · Elk Grove, CA
- Kaiser Permanente-Fremont · Fremont, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- Washington Hospital · Fremont, CA
- Fresno Cancer Center · Fresno, CA
- Kaiser Permanente Fresno Orchard Plaza · Fresno, CA
- Kaiser Permanente-Fresno · Fresno, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- Kaiser Permanente Los Angeles Medical Center · Los Angeles, CA
- Los Angeles General Medical Center · Los Angeles, CA
- USC / Norris Comprehensive Cancer Center · Los Angeles, CA
- Kaiser Permanente- Modesto MOB II · Modesto, CA
- Kaiser Permanente-Modesto · Modesto, CA
- Memorial Medical Center · Modesto, CA
- Palo Alto Medical Foundation-Camino Division · Mountain View, CA
- Kaiser Permanente Oakland-Broadway · Oakland, CA
- Kaiser Permanente-Oakland · Oakland, CA
- Kaiser Permanente-Ontario · Ontario, CA
- Saint Joseph Hospital - Orange · Orange, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Stanford Cancer Institute Palo Alto · Palo Alto, CA
- Kaiser Permanente-Rancho Cordova Cancer Center · Rancho Cordova, CA
- Kaiser Permanente- Marshall Medical Offices · Redwood City, CA
- Kaiser Permanente-Richmond · Richmond, CA
- Kaiser Permanente-Riverside · Riverside, CA
- Mercy Cancer Center - Rocklin · Rocklin, CA
- Rohnert Park Cancer Center · Rohnert Park, CA
- Kaiser Permanente-Roseville · Roseville, CA
- Sutter Cancer Centers Radiation Oncology Services-Roseville · Roseville, CA
- Sutter Roseville Medical Center · Roseville, CA
- The Permanente Medical Group-Roseville Radiation Oncology · Roseville, CA
- Kaiser Permanente Downtown Commons · Sacramento, CA
- Kaiser Permanente-South Sacramento · Sacramento, CA
- Mercy Cancer Center - Sacramento · Sacramento, CA
- South Sacramento Cancer Center · Sacramento, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Kaiser Permanente-San Francisco · San Francisco, CA
- Kaiser Permanente-Santa Teresa-San Jose · San Jose, CA
- Stanford Cancer Center South Bay · San Jose, CA
- Kaiser Permanente San Leandro · San Leandro, CA
- Pacific Central Coast Health Center-San Luis Obispo · San Luis Obispo, CA
- Kaiser San Rafael-Gallinas · San Rafael, CA
- Ridley-Tree Cancer Center · Santa Barbara, CA
- Kaiser Permanente Medical Center - Santa Clara · Santa Clara, CA
- USC Norris Santa Clarita Oncology · Santa Clarita, CA
- Dominican Santa Cruz Hospital · Santa Cruz, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Mission Hope Medical Oncology - Santa Maria · Santa Maria, CA
- Kaiser Permanente-Santa Rosa · Santa Rosa, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- Kaiser Permanente Cancer Treatment Center · South San Francisco, CA
- Kaiser Permanente-South San Francisco · South San Francisco, CA
- Saint Helena Hospital · St. Helena, CA
- Kaiser Permanente-Stockton · Stockton, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- Gene Upshaw Memorial Tahoe Forest Cancer Center · Truckee, CA
- Kaiser Permanente Medical Center-Vacaville · Vacaville, CA
- Kaiser Permanente-Vallejo · Vallejo, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
- Kaiser Permanente-Walnut Creek · Walnut Creek, CA
- Woodland Memorial Hospital · Woodland, CA
Colorado · 17
- UCHealth University of Colorado Hospital · Aurora, CO
- Penrose-Saint Francis Healthcare · Colorado Springs, CO
- Saint Francis Cancer Center · Colorado Springs, CO
- UCHealth Memorial Hospital Central · Colorado Springs, CO
- Rose Medical Center · Denver, CO
- UCHealth - Cherry Creek · Denver, CO
- Dillon Health Center/Shaw Cancer Center · Dillon, CO
- Shaw Cancer Center · Edwards, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- Lutheran Hospital - Cancer Centers of Colorado · Golden, CO
- UCHealth Greeley Hospital · Greeley, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- UCHealth Lone Tree Health Center · Lone Tree, CO
- Longmont United Hospital · Longmont, CO
- Medical Center of the Rockies · Loveland, CO
- Saint Anthony North Hospital · Westminster, CO
Connecticut · 16
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital-Hamden Care Center · Hamden, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital Saint Raphael Campus · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital-Orange Care Center · Orange, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
District of Columbia · 3
- George Washington University Medical Center · Washington D.C., DC
- MedStar Georgetown University Hospital · Washington D.C., DC
- MedStar Washington Hospital Center · Washington D.C., DC
Florida · 28
- AdventHealth Altamonte · Altamonte Springs, FL
- Mount Sinai Comprehensive Cancer Center at Aventura · Aventura, FL
- Florida Cancer Specialists - Bradenton Cancer Center · Bradenton, FL
- UM Sylvester Comprehensive Cancer Center at Coral Gables · Coral Gables, FL
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach · Deerfield Beach, FL
- UM Sylvester Comprehensive Cancer Center at Doral · Doral, FL
- Regional Cancer Center-Lee Memorial Health System · Fort Myers, FL
- UF Health Cancer Institute - Gainesville · Gainesville, FL
- The Watson Clinic · Lakeland, FL
- University of Miami Miller School of Medicine-Sylvester Cancer Center · Miami, FL
- Mount Sinai Medical Center · Miami Beach, FL
- Health Central · Ocoee, FL
- AdventHealth Orlando · Orlando, FL
- Orlando Health Cancer Institute · Orlando, FL
- UM Sylvester Comprehensive Cancer Center at Plantation · Plantation, FL
- First Physicians Group - Silverstein Institute at Floyd Street · Sarasota, FL
- First Physicians Group - Urology Robotic and Minimally Invasive Surgery · Sarasota, FL
- First Physicians Group-Sarasota · Sarasota, FL
- Florida Cancer Specialists - Sarasota · Sarasota, FL
- Florida Cancer Specialists - Sarasota Downtown · Sarasota, FL
- Intercoastal Medical Group - Cattleridge II · Sarasota, FL
- Sarasota Memorial Health Care Center at University Parkway · Sarasota, FL
- Sarasota Memorial Hospital · Sarasota, FL
- Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
- Florida Cancer Specialists - Venice Island · Venice, FL
- Florida Cancer Specialists - Venice Pinebrook · Venice, FL
- Cleveland Clinic-Weston · Weston, FL
- Winter Haven Hospital · Winter Haven, FL
Georgia · 4
- Northside Hospital-Alpharetta · Alpharetta, GA
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.