Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer
NCT06058377
This study is recruiting at 539 US sites in 43 states, according to its ClinicalTrials.gov record last updated .
Summary
This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint High 2 Risk (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- HER2-Negative Breast Carcinoma
- Hormone Receptor-Positive Breast Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- National Cancer Institute (NCI)
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham Cancer Center · Birmingham, AL
Alaska · 1
- Katmai Oncology Group · Anchorage, AK
Arizona · 3
- Banner University Medical Center - Tucson · Tucson, AZ
- University of Arizona Cancer Center-North Campus · Tucson, AZ
- University of Arizona Cancer Center-Orange Grove Campus · Tucson, AZ
Arkansas · 3
- Mercy Hospital Fort Smith · Fort Smith, AR
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro · Jonesboro, AR
- University of Arkansas for Medical Sciences · Little Rock, AR
California · 36
- Sutter Auburn Faith Hospital · Auburn, CA
- Alta Bates Summit Medical Center-Herrick Campus · Berkeley, CA
- Tower Cancer Research Foundation · Beverly Hills, CA
- City of Hope Comprehensive Cancer Center · Duarte, CA
- Palo Alto Medical Foundation-Fremont · Fremont, CA
- City of Hope at Irvine Lennar · Irvine, CA
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- City of Hope Antelope Valley · Lancaster, CA
- Loma Linda University Medical Center · Loma Linda, CA
- City of Hope at Long Beach Elm · Long Beach, CA
- Cedars-Sinai Medical Center · Los Angeles, CA
- The Angeles Clinic and Research Institute - West Los Angeles Office · Los Angeles, CA
- Memorial Medical Center · Modesto, CA
- City of Hope Newport Beach · Newport Beach, CA
- UC Irvine Health/Chao Family Comprehensive Cancer Center · Orange, CA
- Desert Regional Medical Center · Palm Springs, CA
- Palo Alto Medical Foundation Health Care · Palo Alto, CA
- Huntington Memorial Hospital · Pasadena, CA
- Sutter Roseville Medical Center · Roseville, CA
- Sutter Medical Center Sacramento · Sacramento, CA
- SWOG · Sacramento, CA
- California Pacific Medical Center-Pacific Campus · San Francisco, CA
- Mills Health Center · San Mateo, CA
- Palo Alto Medical Foundation-Santa Cruz · Santa Cruz, CA
- Saint John's Cancer Institute · Santa Monica, CA
- Providence Medical Foundation - Santa Rosa · Santa Rosa, CA
- Providence Santa Rosa Memorial Hospital · Santa Rosa, CA
- Sutter Pacific Medical Foundation · Santa Rosa, CA
- City of Hope South Pasadena · South Pasadena, CA
- Palo Alto Medical Foundation-Sunnyvale · Sunnyvale, CA
- Cedars-Sinai Cancer - Tarzana · Tarzana, CA
- City of Hope South Bay · Torrance, CA
- Torrance Memorial Physician Network - Cancer Care · Torrance, CA
- City of Hope Upland · Upland, CA
- Sutter Solano Medical Center/Cancer Center · Vallejo, CA
- UCI Health - Yorba Linda · Yorba Linda, CA
Colorado · 9
- UCHealth University of Colorado Hospital · Aurora, CO
- UCHealth - Cherry Creek · Denver, CO
- Shaw Cancer Center · Edwards, CO
- Cancer Care and Hematology-Fort Collins · Fort Collins, CO
- Poudre Valley Hospital · Fort Collins, CO
- UCHealth Greeley Hospital · Greeley, CO
- UCHealth Highlands Ranch Hospital · Highlands Ranch, CO
- UCHealth Lone Tree Health Center · Lone Tree, CO
- Medical Center of the Rockies · Loveland, CO
Connecticut · 13
- Smilow Cancer Hospital-Derby Care Center · Derby, CT
- Smilow Cancer Hospital Care Center-Fairfield · Fairfield, CT
- Smilow Cancer Hospital Care Center at Glastonbury · Glastonbury, CT
- Smilow Cancer Hospital Care Center at Greenwich · Greenwich, CT
- Smilow Cancer Hospital Care Center - Guilford · Guilford, CT
- Smilow Cancer Hospital Care Center at Saint Francis · Hartford, CT
- Yale University · New Haven, CT
- Yale-New Haven Hospital North Haven Medical Center · North Haven, CT
- Smilow Cancer Hospital Care Center at Long Ridge · Stamford, CT
- Smilow Cancer Hospital-Torrington Care Center · Torrington, CT
- Smilow Cancer Hospital Care Center-Trumbull · Trumbull, CT
- Smilow Cancer Hospital-Waterbury Care Center · Waterbury, CT
- Smilow Cancer Hospital Care Center - Waterford · Waterford, CT
Delaware · 4
- Beebe South Coastal Health Campus · Millville, DE
- Helen F Graham Cancer Center · Newark, DE
- Medical Oncology Hematology Consultants PA · Newark, DE
- Beebe Health Campus · Rehoboth Beach, DE
District of Columbia · 1
- Sibley Memorial Hospital · Washington D.C., DC
Florida · 10
- Mount Sinai Comprehensive Cancer Center at Aventura · Aventura, FL
- Schulze Family Foundation Cancer Clinic - Bonita Health Center · Bonita Springs, FL
- Morton Plant Hospital · Clearwater, FL
- Regional Cancer Center-Lee Memorial Health System · Fort Myers, FL
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital · Hollywood, FL
- Mount Sinai Medical Center · Miami Beach, FL
- Memorial Hospital West · Pembroke Pines, FL
- Mease Countryside Hospital · Safety Harbor, FL
- Saint Joseph's Hospital/Children's Hospital-Tampa · Tampa, FL
- Winter Haven Hospital · Winter Haven, FL
Georgia · 8
- Emory Saint Joseph's Hospital · Atlanta, GA
- Emory University Hospital Midtown · Atlanta, GA
- Emory University Hospital/Winship Cancer Institute · Atlanta, GA
- Grady Health System · Atlanta, GA
- Emory Decatur Hospital · Decatur, GA
- Emory Johns Creek Hospital · Johns Creek, GA
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler · Savannah, GA
- Memorial Health University Medical Center · Savannah, GA
Idaho · 10
- Saint Alphonsus Cancer Care Center-Boise · Boise, ID
- Saint Luke's Cancer Institute - Boise · Boise, ID
- Saint Alphonsus Cancer Care Center-Caldwell · Caldwell, ID
- Kootenai Health - Coeur d'Alene · Coeur d'Alene, ID
- Saint Luke's Cancer Institute - Fruitland · Fruitland, ID
- Saint Luke's Cancer Institute - Meridian · Meridian, ID
- Saint Alphonsus Cancer Care Center-Nampa · Nampa, ID
- Saint Luke's Cancer Institute - Nampa · Nampa, ID
- Kootenai Clinic Cancer Services - Post Falls · Post Falls, ID
- Kootenai Clinic Cancer Services - Sandpoint · Sandpoint, ID
Illinois · 51
- Advocate Outpatient Center - Aurora · Aurora, IL
- Advocate Good Shepherd Hospital · Barrington, IL
- Illinois CancerCare-Bloomington · Bloomington, IL
- Illinois CancerCare-Canton · Canton, IL
- SIH Cancer Institute · Carterville, IL
- Illinois CancerCare-Carthage · Carthage, IL
- Advocate Illinois Masonic Medical Center · Chicago, IL
- Mount Sinai Hospital Medical Center · Chicago, IL
- Northwestern University · Chicago, IL
- University of Illinois · Chicago, IL
- AMG Crystal Lake - Oncology · Crystal Lake, IL
- Carle at The Riverfront · Danville, IL
- Cancer Care Specialists of Illinois - Decatur · Decatur, IL
- Decatur Memorial Hospital · Decatur, IL
- Northwestern Medicine Cancer Center Kishwaukee · DeKalb, IL
- Illinois CancerCare-Dixon · Dixon, IL
- Advocate Good Samaritan Hospital · Downers Grove, IL
- Carle Physician Group-Effingham · Effingham, IL
- Crossroads Cancer Center · Effingham, IL
- Advocate Sherman Hospital · Elgin, IL
- Illinois CancerCare-Eureka · Eureka, IL
- Illinois CancerCare-Galesburg · Galesburg, IL
- Northwestern Medicine Cancer Center Delnor · Geneva, IL
- Northwestern Medicine Glenview Outpatient Center · Glenview, IL
- Northwestern Medicine Grayslake Outpatient Center · Grayslake, IL
- Advocate South Suburban Hospital · Hazel Crest, IL
- Illinois CancerCare-Kewanee Clinic · Kewanee, IL
- Northwestern Medicine Lake Forest Hospital · Lake Forest, IL
- AMG Libertyville - Oncology · Libertyville, IL
- Condell Memorial Hospital · Libertyville, IL
- Illinois CancerCare-Macomb · Macomb, IL
- Carle Physician Group-Mattoon/Charleston · Mattoon, IL
- Loyola University Medical Center · Maywood, IL
- Trinity Medical Center · Moline, IL
- SSM Health Good Samaritan · Mount Vernon, IL
- Carle BroMenn Medical Center · Normal, IL
- Carle Cancer Institute Normal · Normal, IL
- Cancer Care Center of O'Fallon · O'Fallon, IL
- Northwestern Medicine Oak Brook · Oak Brook, IL
- Advocate Christ Medical Center · Oak Lawn, IL
- Northwestern Medicine Orland Park · Orland Park, IL
- Illinois CancerCare-Ottawa Clinic · Ottawa, IL
- Advocate Lutheran General Hospital · Park Ridge, IL
- Illinois CancerCare-Pekin · Pekin, IL
- Illinois CancerCare-Peoria · Peoria, IL
- Illinois CancerCare-Peru · Peru, IL
- Illinois CancerCare-Princeton · Princeton, IL
- OSF Saint Anthony Medical Center · Rockford, IL
- UW Health Carbone Cancer Center Rockford · Rockford, IL
- Memorial Hospital East · Shiloh, IL
- Southern Illinois University School of Medicine · Springfield, IL
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.