A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors
NCT05208762
This study is recruiting at 25 US sites in 8 states, according to its ClinicalTrials.gov record last updated .
Summary
This study will test the safety of a drug called PF-08046054/SGN-PDL1V alone and with pembrolizumab in participants with solid tumors. It will also study the side effects of this drug. A side effect is anything a drug does to your body besides treating your disease. Participants will have solid tumor cancer that has spread through the body (metastatic) or cannot be removed with surgery (unresectable). This study will have five parts. Parts A and B of the study will find out how much PF-08046054/SGN- PDL1V should be given to participants.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Carcinoma, Non-Small-Cell Lung
- Squamous Cell Carcinoma of the Head and Neck
- Esophageal Squamous Cell Carcinoma
- Triple Negative Breast Neoplasms
- Gastric Cancer
- Endometrial Cancer
- Pancreatic Adenocarcinoma
- Hepatocellular Carcinoma
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
- Last updated on ClinicalTrials.gov
- July 22, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 4
- University of Alabama at Birmingham · Birmingham, AL
- University of Alabama at Birmingham · Birmingham, AL
- University of Alabama at Birmingham · Birmingham, AL
- University of Alabama at Birmingham, IDS Pharmacy · Birmingham, AL
California · 4
- Chao Family Comprehensive Cancer Center and Ambulatory Care · Irvine, CA
- UC Irvine Health - Chao Family Comprehensive Cancer Center · Orange, CA
- University of California Davis Comprehensive Cancer Center · Sacramento, CA
- University of California, Davis Medical Center · Sacramento, CA
Iowa · 1
- University of Iowa · Iowa City, IA
Michigan · 2
- Karmanos Cancer Institute · Detroit, MI
- Karmanos Cancer Institute · Farmington Hills, MI
Ohio · 1
- University Hospitals Cleveland Medical Center · Cleveland, OH
Texas · 11
- Univ. of TX Southwestern Medical Center - Zale Lipshy University Hospital · Dallas, TX
- University Of Texas Southwestern Medical Center · Dallas, TX
- University of Texas Southwestern Medical Center - Simmons Cancer Center · Dallas, TX
- University of Texas Southwestern Medical Center - William P. Clements, Jr., University Hospital · Dallas, TX
- UT Southwestern Medical Center - Redbird · Dallas, TX
- UT Southwestern - Simmons Cancer Center - Fort Worth · Fort Worth, TX
- The University of Texas MD Anderson Cancer Center · Houston, TX
- The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services · Houston, TX
- UT Southwestern - Simmons Cancer Center - Richardson/Plano · Richardson, TX
- NEXT Virginia, LLC · San Antonio, TX
- South Texas Accelerated Research Therapeutics, LLC · San Antonio, TX
Utah · 1
- START Mountain Region · West Valley City, UT
Virginia · 1
- NEXT Virginia · Fairfax, VA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.