A Study of Sigvotatug Vedotin in Advanced Solid Tumors
NCT04389632
This study is recruiting at 94 US sites in 18 states, according to its ClinicalTrials.gov record last updated .
Summary
This trial will look at a drug called sigvotatug vedotin (SGN-B6A) alone and with pembrolizumab, with or without chemotherapy, to find out whether it is safe for people who have solid tumors. It will study sigvotatug vedotin to find out what its side effects are. A side effect is anything the drug does besides treating cancer. It will also study whether sigvotatug vedotin works to treat solid tumors. The study will have four parts. Part A of the study will find out how much sigvotatug vedotin should be given to participants.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Carcinoma, Non-Small Cell Lung
- Squamous Cell Carcinoma of Head and Neck
- HER2 Negative Breast Neoplasms
- Esophageal Squamous Cell Carcinoma
- Esophageal Adenocarcinoma
- Gastroesophageal Junction Adenocarcinoma
- Ovarian Neoplasms
- Cutaneous Squamous Cell Cancer
- Exocrine Pancreatic Adenocarcinoma
- Urinary Bladder Neoplasms
- Uterine Cervical Neoplasms
- Stomach Neoplasms
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 1
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Seagen, a wholly owned subsidiary of Pfizer
- Last updated on ClinicalTrials.gov
- July 6, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 1
- Alaska Oncology and Hematology · Anchorage, AK
Arkansas · 3
- Highlands Oncology Group · Fayetteville, AR
- Highlands Oncology Group · Rogers, AR
- Highlands Oncology Group · Springdale, AR
California · 7
- Providence Medical Foundation · Anaheim, CA
- Providence Medical Foundation · Fullerton, CA
- Providence St. Jude Medical Center Virginia K Crosson and Infusion Center · Fullerton, CA
- Ronald Reagan UCLA Medical Center · Los Angeles, CA
- The Regents of the University of California · Los Angeles, CA
- UCLA Department of Medicine-Hematology/Oncology · Los Angeles, CA
- UCLA Department of Medicine - Hematology & Oncology · Santa Monica, CA
Florida · 7
- American Oncology Partners, PA. a Florida professional service corporation, d/b/a Vista Oncology · Fort Myers, FL
- Florida Cancer Specialists & Research Institute, LLC · Fort Myers, FL
- Memorial Cancer Institute · Hollywood, FL
- Memorial Healthcare System · Hollywood, FL
- Florida Cancer Specialists · Orlando, FL
- Memorial Cancer Institute at Memorial Hospital West · Pembroke Pines, FL
- Memorial Hospital West · Pembroke Pines, FL
Illinois · 16
- Ingalls Family Care Center · Calumet City, IL
- The University Of Chicago · Chicago, IL
- UChicago Medicine - River East · Chicago, IL
- University of Chicago Medical Center · Chicago, IL
- UChicago Medicine at Ingalls - Flossmoor · Flossmoor, IL
- UChicago Medicine Ingalls Memorial · Harvey, IL
- University of Chicago Comprehensive Cancer Center at Silver Cross Hospital · New Lenox, IL
- The University of Chicago Medicine Center for Advanced Care Orland Park · Orland Park, IL
- Southern Illinois University - Simmons Cancer Institute · Springfield, IL
- Springfield Clinic · Springfield, IL
- Springfield Clinic Main Campus · Springfield, IL
- Springfield Clinic Radiology - 800 Building · Springfield, IL
- Springfield Clinic Radiology - Main Campus · Springfield, IL
- Springfield Clinic Urgent Care Plus · Springfield, IL
- Springfield Memorial Hospital · Springfield, IL
- UChicago Medicine at Ingalls - Tinley Park · Tinley Park, IL
Indiana · 6
- UChicago Medicine - Northwest Indiana · Crown Point, IN
- Fort Wayne Medical Oncology and Hematology, Inc · Fort Wayne, IN
- Community Health Network Investigational Drug Services · Indianapolis, IN
- Community Health Network, Inc · Indianapolis, IN
- Community Health Network, Inc. · Indianapolis, IN
- Community Health Network, Inc. · Indianapolis, IN
Kansas · 9
- The University of Kansas Cancer Center, Investigational Drug Services · Fairway, KS
- The University of Kansas Clinical Research Center · Fairway, KS
- The University of Kansas Hospital · Kansas City, KS
- The University of Kansas Medical Center Medical Office Building · Kansas City, KS
- University of Kansas Hospital Cambridge North Tower A · Kansas City, KS
- University of Kansas Medical Center Research Institute · Kansas City, KS
- The University of Kansas Cancer Center - Indian Creek Campus · Overland Park, KS
- The University of Kansas Cancer Center - Westwood · Westwood, KS
- University of Kansas Cancer Center · Westwood, KS
Massachusetts · 6
- Beth Israel Deaconess Medical Center · Boston, MA
- Beth Israel Deaconess Medical Center,East Campus Research Pharmacy · Boston, MA
- Brigham & Women's Hospital · Boston, MA
- Dana Farber Cancer Institute · Boston, MA
- Massachusetts General Hospital · Boston, MA
- Dana-Farber Cancer Institute - Chestnut Hill · Newton, MA
Minnesota · 4
- Allina Health Cancer Institute - Mercy Hospital · Coon Rapids, MN
- Allina Health Cancer Institute - Abbott Northwestern Hospital · Minneapolis, MN
- Allina Health Cancer Institute · Saint Paul, MN
- Allina Health Cancer Institute - United Hospital · Saint Paul, MN
Nevada · 1
- Comprehensive Cancer Centers of Nevada · Las Vegas, NV
New York · 10
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · Babylon, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · Brooklyn, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · New Hyde Park, NY
- Columbia University Irving Medical Center · New York, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · New York, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · Patchogue, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · Port Jefferson Station, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · Riverhead, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · Shirley, NY
- North Shore Hematology Oncology Associates P.C. DBA New York Cancer and Blood Specialists · The Bronx, NY
Oklahoma · 3
- OU Health University of Oklahoma Medical Center · Oklahoma City, OK
- Stephenson Cancer Center (chemo location) · Oklahoma City, OK
- University of Oklahoma Health Science Center · Oklahoma City, OK
Oregon · 4
- Providence Cancer Institute Franz Clinic · Portland, OR
- Providence Oncology and Hematology Care Clinic - Westside · Portland, OR
- Providence St. Vincent Medical Center · Portland, OR
- Providence St. Vincent Medical Center- Investigational Drug Services · Portland, OR
South Dakota · 2
- Sanford Cancer Center · Sioux Falls, SD
- Sanford USD Medical Center · Sioux Falls, SD
Tennessee · 1
- US Oncology Research LLC · Nashville, TN
Texas · 6
- Oncology Consultants, PA · Houston, TX
- Oncology Consultants, PA. · Houston, TX
- The University of Texas M.D. Anderson Cancer Center · Houston, TX
- US Oncology Investigational Product Center (IPC) · Irving, TX
- UT Health East Texas Hope Cancer Center · Tyler, TX
- UT Health East Texas HOPE Cancer Center · Tyler, TX
Virginia · 1
- Virginia Cancer Specialists · Fairfax, VA
Washington · 7
- Swedish Cancer Institute - Edmonds Campus · Edmonds, WA
- Swedish Cancer Institute Edmonds Campus · Edmonds, WA
- American Oncology Network Vista Oncology Division-East office · Olympia, WA
- American Oncology Network Vista Oncology Division-West office · Olympia, WA
- Swedish Cancer Institute · Seattle, WA
- Swedish Medical Center · Seattle, WA
- Exigent Research, LLC · Tacoma, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.