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Obesity Clinical Trials Recruiting in the US

553 studies for Obesity are recruiting at 2,296 US sites, according to ClinicalTrials.gov data processed .

Obesity is a long-term condition defined by excess body fat, often measured using body mass index (BMI).

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Recruiting now

Top Obesity studies by number of US sites

Showing 30 studies, most US recruiting sites first.
  1. Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity

    NCT07037433

    • Phase 3
    • Ages 45 to 99 years
    • Sex: All
    Recruiting sites
    137 US recruiting sites
  2. A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity

    NCT07567001

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    130 US recruiting sites
  3. Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

    NCT07037459

    • Phase 3
    • Ages 18 to 99 years
    • Sex: All
    Recruiting sites
    119 US recruiting sites
  4. Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)

    NCT07684235

    • Phase 3
    • Ages 18 to 99 years
    • Sex: All
    Recruiting sites
    71 US recruiting sites
  5. A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

    NCT07794579

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    69 US recruiting sites
  6. A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, and Type 2 Diabetes

    NCT07282600

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    60 US recruiting sites
  7. A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

    NCT07392190

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    56 US recruiting sites
  8. Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities

    NCT07752979

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    55 US recruiting sites
  9. Efficacy, Safety and Tolerability of Switching From Glucagon-like Peptide-1 Receptor Agonists (GLP-1RA) to Maridebart Cafraglutide in Adults With Obesity or Overweight (MARITIME-SWITCH)

    NCT07575399

    • Phase 3
    • Ages 18 to 99 years
    • Sex: All
    Recruiting sites
    51 US recruiting sites
  10. A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight and Type 2 Diabetes

    NCT07351058

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    45 US recruiting sites
  11. A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

    NCT07351045

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    44 US recruiting sites
  12. A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

    NCT06143956

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    43 US recruiting sites
  13. A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

    NCT07654374

    • Phase 3
    • Ages 18 to 79 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    43 US recruiting sites
  14. A Study of Eloralintide (LY3841136) in Participants With Obesity, or Overweight Without Type 2 Diabetes

    NCT07321886

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    41 US recruiting sites
  15. A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

    NCT07589608

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    40 US recruiting sites
  16. A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

    NCT06857942

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    39 US recruiting sites
  17. AMAZE 9: A Research Study Investigating How Well Zenagamtide Tablets Help People With Excess Body Weight Lose Weight

    NCT07720271

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    39 US recruiting sites
  18. Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

    NCT07353931

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    38 US recruiting sites
  19. Mirikizumab Administered at the Same Time as Tirzepatide in Adult Participants With Moderately to Severely Active Ulcerative Colitis and Obesity or Overweight: Phase 3b Study

    NCT06937086

    • Phase 3
    • Ages 18 to 70 years
    • Sex: All
    Recruiting sites
    37 US recruiting sites
  20. Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

    NCT06937099

    • Phase 3
    • Ages 18 to 70 years
    • Sex: All
    Recruiting sites
    35 US recruiting sites
  21. A Research Study Investigating How Well the Medicine Zenagamtide Helps People With Excess Body Weight Lose Weight Compared to Semaglutide

    NCT07668414

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    33 US recruiting sites
  22. Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-2-EXTENSION)

    NCT07684144

    • Phase 3
    • Ages 18 to 99 years
    • Sex: All
    Recruiting sites
    31 US recruiting sites
  23. A Study to Learn About the Study Medicine Called Berobenatide (PF-08653944) in People With Overweight or Obesity

    NCT07595549

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    30 US recruiting sites
  24. A Study of Clazakizumab (LY5724886) in Adults With Elevated hsCRP and at Increased Risk for Cardiovascular Event

    NCT07783802

    • Phase 2
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    29 US recruiting sites
  25. A Research Study on How Well Cagrilintide and CagriSema Work in Children and Adolescents With Excess Body Weight

    NCT07253285

    • Phase 3
    • Ages 8 to 18 years
    • Sex: All
    Recruiting sites
    27 US recruiting sites
  26. The RESET System Pivotal Clinical Trial (Protocol Revision K)

    NCT04101669

    • Interventional
    • Ages 22 to 65 years
    • Sex: All
    Recruiting sites
    26 US recruiting sites
  27. A Study of LY3457263 Compared With Placebo in Participants With Type 2 Diabetes on a Stable Dose of Semaglutide or Tirzepatide

    NCT06897475

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    25 US recruiting sites
  28. A Study of Eloralintide (LY3841136) in Participants With Obstructive Sleep Apnea and Obesity or Overweight

    NCT07369011

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    23 US recruiting sites
  29. AMAZE 1: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight Lose Weight

    NCT07339423

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    22 US recruiting sites
  30. Study of Olatorepatide in Adult Participants Living With Overweight or Obesity Without Diabetes

    NCT07685808

    • Phase 2
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    21 US recruiting sites

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Obesity clinical trials by city

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining an Obesity clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.