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Lung Cancer Clinical Trials near Orange, CA

228 studies for Lung Cancer are recruiting at 533 sites within 50 miles of Orange, California, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Lung Cancer trials in the US or all trials near Orange.

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Lung Cancer studies enrolling near Orange

Showing the 50 nearest of 228 studies.
  1. A Study of Amivantamab in Combination With Lazertinib, or Amivantamab in Combination With Platinum-Based Chemotherapy, for Common Epidermal Growth Factor Receptor (EGFR)-Mutated Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

    NCT06667076

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: St. Joseph Hospital Center for Cancer Prevention and Treatment (Orange, CA); University of California Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    18 sites within 50 mi
  2. Empowering Patients' Lung Cancer Screening Uptake (Empower LCS/Call+)

    NCT07711691

    • Interventional
    • Ages 50 to 80 years
    • Sex: All

    Nearest sites: Primary Care & Internal Medicine Services (Orange, CA); UCI Chao Family Comprehensive Cancer Center (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    13 sites within 50 mi
  3. Clinical Study of Ivonescimab for First-line Treatment of Metastatic NSCLC Patients With High PD-L1

    NCT06767514

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Clinical Study Site (Orange, CA); Clinical Study Site (Anaheim, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    7 sites within 50 mi
  4. Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

    NCT06350097

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Research Site (Orange, CA); Research Site (Los Alamitos, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  5. A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)

    NCT06858813

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University Of California Irvine Medical Center /ID# 270507 (Orange, CA); City of Hope - Orange County Lennar Foundation Cancer Center /ID# 276120 (Irvine, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  6. Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

    NCT05983432

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California Irvine Medical Center (Orange, CA); City of Hope Cancer Center (Duarte, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  7. A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)

    NCT06312137

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 4002) (Orange, CA); Hoag Memorial Hospital Presbyterian ( Site 0096) (Newport Beach, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  8. Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  9. Beamion LUNG-3: Adjuvant Zongertinib vs Standard Treatment in People With Completely Resected Stage II-IIIB NSCLC Harboring Activating HER2 TKD Mutations

    NCT07195695

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California Irvine (Orange, CA); OPN Healthcare, Inc. (Glendale, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  10. SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    NCT03452774

    • Observational
    • Ages Any age
    • Sex: All

    Nearest sites: Massive Bio SYNERGY-AI site (Orange, CA); Massive Bio SYNERGY-AI site (Irvine, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  11. Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer

    NCT06890598

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California, Irvine (UCI) Health - UC Irvine Medical Center (Orange, CA); UCLA Hematology/Oncology - Santa Monica (Los Angeles, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  12. Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  13. A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

    NCT04302025

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: The Center for Cancer Prevention and Treatment at St.Joseph Hospital of Orange (Orange, CA); University of California Los Angeles - Jonsson Comprehensive Cancer Center (Los Angeles, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  14. A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

    NCT05208762

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health - Chao Family Comprehensive Cancer Center (Orange, CA); Chao Family Comprehensive Cancer Center and Ambulatory Care (Irvine, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  15. Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

    NCT05379985

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine/Chao Family Comprehensive Cancer Center (Orange, CA); UCLA (Santa Monica, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  16. A Study of VET3-TGI in Patients With Solid Tumors

    NCT06444815

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UC Irvine Health (Orange, CA); USC/Norris Comprehensive Cancer Center (Los Angeles, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  17. Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC

    NCT06765109

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California, Irvine Health (Orange, CA); Hoag Hospital Newport Beach (Newport Beach, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  18. Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

    NCT07100080

    • Phase 2/3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California, Irvine (UCI) Health - UC Irvine Medical Center (Orange, CA); UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care building (Irvine, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  19. A Study of Gilteritinib in Adults With Advanced ALK-positive Non-small Cell Lung Cancer (NSCLC)

    NCT07140016

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: University of California - Irvine (Orange, CA); Providence Medical Foundation - Fullerton - Virginia K. Crosson Cancer Center (Fullerton, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  20. Phase 3 Study of Taletrectinib vs Placebo as an Adjuvant Therapy in ROS1 Positive NSCLC (TRUST-IV)

    NCT07154706

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UCI Chao Family Comprehensive Cancer Center (Orange, CA); UCLA (Los Angeles, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  21. First-in-Human Study of PLX-61639 in Locally Advanced or Metastatic Solid Tumors

    NCT07284186

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Research Site (Orange, CA); Research Site (Duarte, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  22. A Safety and Efficacy Study of EIK1001 in Combination With Pembrolizumab and Chemotherapy in Participants With Stage 4 Non-Small Cell Lung Cancer.

    NCT07365319

    • Phase 2/3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence St. Joseph Hospital (Orange, CA); Los Angeles Cancer Network (Glendale, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  23. Patient-Derived Xenografts to Reduce Cancer Health Disparities

    NCT04410302

    • Observational
    • Ages 21 to 100 years
    • Sex: All

    Nearest site: UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

    NCT04701476

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: University of California, Irvine Medical Center (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

    NCT06128551

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest site: UC IRVINE Health (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. Assess Diversity of Gut Microbiome in Met NSCLC in Correlation to Tx & Adverse Effects

    NCT06221800

    • Observational
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center University of California, Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

    NCT06580002

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center, University of California Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. Lung Cancer Screening of Family Members of Patients With Mutation-Driven Lung Cancer

    NCT07062172

    • Interventional
    • Ages 18 to 80 years
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center University of California, Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. Trial of Single Protein Encapsulated Doxorubicin, SPEDOX-6 in Advanced Malignancies

    NCT07064018

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center University of California, Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

    NCT07447050

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chao Family Comprehensive Cancer Center, University of California Irvine (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  33. Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

    NCT03851445

    • Phase 2/3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Kaiser Permanente-Anaheim (Anaheim, CA); City of Hope at Irvine Lennar (Irvine, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    23 sites within 50 mi
  34. Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

    NCT06616584

    • Phase 2/3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Kaiser Permanente-Anaheim (Anaheim, CA); City of Hope at Irvine Lennar (Irvine, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    20 sites within 50 mi
  35. Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

    NCT07222566

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Oncura Health - Anaheim (Anaheim, CA); Memorial Care Orange Coast Medical Center Attn (Fountain Valley, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    16 sites within 50 mi
  36. Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

    NCT04267848

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Kaiser Permanente-Anaheim (Anaheim, CA); Kaiser Permanente-Irvine (Irvine, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    13 sites within 50 mi
  37. A Study of Sigvotatug Vedotin in Advanced Solid Tumors

    NCT04389632

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Anaheim, CA); Providence Medical Foundation (Fullerton, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    7 sites within 50 mi
  38. A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

    NCT06692738

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Research Site (Anaheim, CA); Research Site (Los Alamitos, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  39. Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

    NCT04613596

    • Phase 2/3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence - Saint Joseph Home Health - Anaheim (Anaheim, CA); TRIO - Cancer & Blood Specialty Clinic - Los Alamitos (Los Alamitos, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  40. A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Non-Squamous NSCLC

    NCT06627647

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Research Site (Anaheim, CA); Research Site (Beverly Hills, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  41. Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  42. Study of Sacituzumab Govitecan Versus Standard of Care in Participants With Previously Treated Extensive Stage Small Cell Lung Cancer

    NCT06801834

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Los Angeles Cancer Network (Anaheim, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. Symbiotic-Lung-20: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Different Anticancer Agents in Advanced Cancers

    NCT07227298

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Fullerton, CA); Providence St. Jude Medical Center (Fullerton, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    9 sites within 50 mi
  44. Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

    NCT05098132

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Fullerton, CA); Hoag Memorial Hospital Presbyterian (Newport Beach, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  45. A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

    NCT06623422

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence St. Jude Medical Center ( Site 0106) (Fullerton, CA); VA Long Beach Healthcare System ( Site 0199) (Long Beach, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  46. This is a Study to Learn About How the Combination of the Study Medicines Sigvotatug Vedotin Plus Pembrolizumab Works in People With Non-small Cell Lung Cancer With High Levels of PD-L1.

    NCT06758401

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Fullerton, CA); Providence St. Jude Medical Center (Fullerton, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  47. Comparative Effectiveness Trial of Two Supportive Cancer Care Delivery Models for Adults With Cancer

    NCT05297734

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: St Jude Heritage Medical Group (Fullerton, CA); Beckman Research Institute of City of Hope (Duarte, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  48. First in Human Study of TORL-1-23 in Participants With Advanced Cancer

    NCT05103683

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Providence Medical Foundation (Fullerton, CA); UCLA - JCCC Clinical Research Unit (Los Angeles, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  49. A Study of Ifinatamab Deruxtecan Versus Treatment of Physician's Choice in Subjects With Relapsed Small Cell Lung Cancer

    NCT06203210

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Clinical Research Providence Medical Foundation (Fullerton, CA); UCLA Hematology-Oncology (Los Angeles, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  50. LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

    NCT06216301

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: St. Jude Herritage Medical Group (Fullerton, CA); Hoag Family Cancer Institute - Hoag Memorial Hospital (Newport Beach, CA)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    2 sites within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Lung Cancer clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.