A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
NCT06793215
This study is recruiting at 63 US sites in 28 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non-Small Cell Lung Cancer
- KRAS G12C Lung Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Hoffmann-La Roche
- Last updated on ClinicalTrials.gov
- October 6, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alaska · 1
- Alaska Oncology and Hematology · Anchorage, AK
Arizona · 1
- City of Hope - Phoenix · Goodyear, AZ
California · 9
- Community Cancer Institute (CCI) · Clovis, CA
- Marin Cancer Care Inc · Greenbrae, CA
- UCI Health-CIACC · Irvine, CA
- UCLA Oncology Center · Los Angeles, CA
- Hoag Memorial Hospital · Newport Beach, CA
- University of California Irvine · Orange, CA
- Palo Alto Medical Foundation Research Center · Palo Alto, CA
- Sutter Institute for Medical Research · Roseville, CA
- California Pacific Medical Center · San Francisco, CA
Colorado · 2
- UC Health Oncology Research · Colorado Springs, CO
- Poudre Valley Health Care, Inc. d/b/a Poudre Valley Health System · Fort Collins, CO
Connecticut · 1
- Hartford Hospital · Hartford, CT
Florida · 9
- Florida Cancer Specialists - SOUTH - SCRI - PPDS · Fort Myers, FL
- University of Florida Health at Shands · Gainesville, FL
- BioResearch Partner · Hialeah, FL
- Memorial Healthcare System - Memorial Regional Hospital · Hollywood, FL
- Sylvester Comprehensive Cancer Center · Miami, FL
- Advent Health Orlando · Orlando, FL
- Ascension Sacred Heart · Pensacola, FL
- Florida Cancer Specialists - NORTH - SCRI - PPDS · St. Petersburg, FL
- Florida Cancer Specialists - EAST - SCRI - PPDS · West Palm Beach, FL
Georgia · 3
- Piedmont Cancer Institute, PC · Atlanta, GA
- City of Hope® Atlanta · Newnan, GA
- Summit Cancer Care PC · Savannah, GA
Idaho · 1
- St. Luke's Cancer Institute · Boise, ID
Illinois · 2
- Affiliated Oncologists, LLC · Chicago Ridge, IL
- City of Hope® Cancer Center Chicago · Zion, IL
Iowa · 2
- Mission Cancer + Blood - IMMC · Des Moines, IA
- University of Iowa · Iowa City, IA
Maryland · 2
- Saint Agnes Hospital - Baltimore - Hunt - PPDS · Baltimore, MD
- Walter Reed National Military Medical Center · Bethesda, MD
Massachusetts · 2
- Massachusetts General Hospital · Boston, MA
- University of Massachusetts Memorial Medical Center · Worcester, MA
Michigan · 1
- Profound Research, LLC · Farmington Hills, MI
Minnesota · 1
- Metro-Minnesota Community Oncology Research Consortium · Saint Louis Park, MN
Missouri · 1
- Missouri Baptist Medical Center · St Louis, MO
Nebraska · 1
- NHO Revive Research Institute · Lincoln, NE
Nevada · 1
- Cancer Care Specialists · Reno, NV
New Jersey · 1
- AsteraCancer Care · East Brunswick, NJ
New Mexico · 1
- San Juan Oncology Associates · Farmington, NM
New York · 3
- SUNY Upstate Medical University · Syracuse, NY
- Montefiore Einstein Cancer Center · The Bronx, NY
- Clinical Research Alliance · Westbury, NY
North Carolina · 1
- Firsthealth of The Carolinas · Pinehurst, NC
Ohio · 1
- Ohio State University · Columbus, OH
Oregon · 1
- Oregon Health and Science University · Portland, OR
Pennsylvania · 3
- St. Luke's University Health Network · Bethlehem, PA
- Allegheny Cancer Center · Pittsburgh, PA
- Reading Hospital - McGlinn Cancer Institute · West Reading, PA
Tennessee · 1
- Baptist Cancer Center · Memphis, TN
Texas · 8
- The University of Texas Southwestern Medical Center at Dallas · Dallas, TX
- Renovatio Clinical - El Paso · El Paso, TX
- JPS Health Network · Fort Worth, TX
- The University of Texas MD Anderson Cancer Center · Houston, TX
- Community Clinical Trials · Kingwood, TX
- Texas Tech Health Science Center · Lubbock, TX
- Renovatio Clinical · The Woodlands, TX
- University of Texas Health Center at Tyler · Tyler, TX
Virginia · 1
- Virginia Oncology Associates · Norfolk, VA
Wisconsin · 2
- Ascension Network - St Elizabeth's Hospital · Appleton, WI
- Ascension Columbia St. Mary's · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.