A Study to Assess Efficacy and Safety of Pembrolizumab With or Without Sacituzumab Tirumotecan (MK- 2870) in Adult Participants With Resectable Non Small Cell Lung Cancer (NSCLC) Not Achieving Pathological Complete Response (pCR) (MK-2870-019)
NCT06312137
This study is recruiting at 45 US sites in 23 states, according to its ClinicalTrials.gov record last updated .
Summary
This study will assess if adding sacituzumab tirumotecan with pembrolizumab after surgery is effective in treating NSCLC for participants not achieving pathological complete response. The primary hypothesis of this study is sacituzumab tirumotecan plus pembrolizumab is superior to pembrolizumab monotherapy with respect to disease free survival (DFS) as assessed by blinded independent central review (BICR).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Non Small Cell Lung Cancer
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Merck Sharp & Dohme LLC
- Last updated on ClinicalTrials.gov
- October 15, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arkansas · 2
- UAMS Winthrop P. Rockefeller Cancer Institute ( Site 0060) · Little Rock, AR
- Highlands Oncology Group-Research Department ( Site 0062) · Springdale, AR
California · 5
- Beverly Hills Cancer Center ( Site 0070) · Beverly Hills, CA
- UCLA Clinical & Translational Research Center (CTRC) ( Site 0033) · Los Angeles, CA
- Hoag Memorial Hospital Presbyterian ( Site 0096) · Newport Beach, CA
- St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 4002) · Orange, CA
- San Francisco Oncology Associates ( Site 0066) · San Francisco, CA
Connecticut · 1
- Stamford Hospital ( Site 0083) · Stamford, CT
Florida · 3
- Mayo Clinic in Florida ( Site 0014) · Jacksonville, FL
- Mount Sinai Cancer Center ( Site 0038) · Miami Beach, FL
- Mid Florida Hematology and Oncology Center ( Site 0018) · Orange City, FL
Georgia · 6
- Emory University School of Medicine-Phase I ( Site 0056) · Atlanta, GA
- Northside Hospital ( Site 0055) · Atlanta, GA
- Piedmont Atlanta Hospital ( Site 4000) · Atlanta, GA
- Southeastern Regional Medical Center ( Site 0065) · Newnan, GA
- Lewis Cancer and Research Pavilion ( Site 0063) · Savannah, GA
- Archbold Cancer Center ( Site 0071) · Thomasville, GA
Illinois · 2
- North Shore University Health System ( Site 4014) · Evanston, IL
- Accellacare of Duly ( Site 4005) · Lisle, IL
Indiana · 2
- Parkview Research Center at Parkview Regional Medical Center ( Site 0089) · Fort Wayne, IN
- Indiana University Health Arnett Cancer Center ( Site 0076) · Lafayette, IN
Kentucky · 1
- Saint Elizabeth Medical Center Edgewood-Cancer Care Center ( Site 0061) · Edgewood, KY
Louisiana · 2
- LSU Health Baton Rouge North Clinic ( Site 4003) · Baton Rouge, LA
- Our Lady of the Lake Physician Group-Medical Oncology ( Site 0080) · Baton Rouge, LA
Maine · 1
- New England Cancer Specialists ( Site 0095) · Westbrook, ME
Minnesota · 2
- Allina Health Cancer Institute - Abbott Northwestern Hospital ( Site 0027) · Minneapolis, MN
- Mayo Clinic - Rochester ( Site 0073) · Rochester, MN
Missouri · 2
- Mercy Research - David C. Pratt Cancer Center ( Site 0006) · St Louis, MO
- Mercy South - David M Sindelar Cancer Center ( Site 0098) · St Louis, MO
Nevada · 1
- Renown Regional Medical Center-Renown Health Medical Oncology ( Site 0037) · Reno, NV
New Jersey · 1
- Atlantic Health Morristown Medical Center ( Site 0077) · Morristown, NJ
New York · 3
- Cayuga Medical Center ( Site 0086) · Ithaca, NY
- University Hospital at Stony Brook ( Site 0054) · Stony Brook, NY
- White Plains Hospital ( Site 0091) · White Plains, NY
North Dakota · 1
- Sanford Fargo Medical Center-Roger Maris Cancer Center ( Site 0057) · Fargo, ND
Oklahoma · 1
- Hightower Clinical, LLC ( Site 0084) · Oklahoma City, OK
Oregon · 1
- Oregon Health and Science University ( Site 0052) · Portland, OR
Pennsylvania · 2
- Penn State Milton S. Hershey Medical Center-Penn State Cancer Institute ( Site 0059) · Hershey, PA
- Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 0068) · Lancaster, PA
South Carolina · 2
- Saint Joseph's Candler Health System ( Site 4010) · Bluffton, SC
- Medical University of South Carolina-Hollings Cancer Center ( Site 0045) · Charleston, SC
South Dakota · 2
- Avera Cancer Institute- Research ( Site 0090) · Sioux Falls, SD
- Sanford Cancer Center ( Site 0053) · Sioux Falls, SD
Tennessee · 1
- University of Tennessee Medical Center Knoxville ( Site 0082) · Knoxville, TN
Utah · 1
- Huntsman Cancer Institute ( Site 0042) · Salt Lake City, UT
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.