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Post-Surgical Pain Clinical Trials Recruiting in the US

122 studies for Post-Surgical Pain are recruiting at 172 US sites, according to ClinicalTrials.gov data processed .

Post-surgical pain is pain that follows an operation as the body heals.

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Recruiting now

Top Post-Surgical Pain studies by number of US sites

Showing 30 studies, most US recruiting sites first.
  1. Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial

    NCT05991453

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    22 US recruiting sites
  2. A Multicenter Patient Registry on Outcomes From Cryoanalgesia of the Intercostal Nerves

    NCT05110989

    • Observational
    • Ages 12 years and older
    • Sex: All
    Recruiting sites
    6 US recruiting sites
  3. Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial

    NCT05722002

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    6 US recruiting sites
  4. Study to Evaluate the Pharmacokinetics and Safety of EXPAREL for Postoperative Analgesia in Subjects Undergoing Cardiac Surgery

    NCT06271265

    • Phase 1
    • Ages 0 to 6 years
    • Sex: All
    Recruiting sites
    5 US recruiting sites
  5. Comparing Analgesic Regimen Effectiveness and Safety for Surgery for Kids Trial

    NCT06671002

    • Phase 4
    • Ages 12 to 20 years
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  6. Opioid-Free Orthopaedics

    NCT04659317

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  7. Pain Injection Versus Epidural Anesthesia for Hip Surgery in Pediatric Patients With Cerebral Palsy

    NCT06189781

    • Phase 4
    • Ages Up to 18 years
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  8. PF614 Analgesic Activity in Acute Postoperative Pain (PF614-301)

    NCT06602271

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  9. Intraperitoneal Infusion of Analgesic for Postoperative Pain Management

    NCT04130464

    • Phase 4
    • Ages 18 to 65 years
    • Sex: Female
    • Accepts healthy volunteers
    Recruiting sites
    2 US recruiting sites
  10. Pain Relief After Trapeziectomy: Ibuprofen & Acetaminophen Versus Oxycodone

    NCT04676802

    • Phase 2
    • Ages 45 years and older
    • Sex: All
    Recruiting sites
    2 US recruiting sites
  11. Chronic Postsurgical Pain

    NCT05764681

    • Observational
    • Ages 5 to 17 years
    • Sex: All
    Recruiting sites
    2 US recruiting sites
  12. Prospective Study of Sensation and Satisfaction in Cancer and Transgender Mastectomy Patients

    NCT06094257

    • Observational
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    2 US recruiting sites
  13. A Study on TLC590 for Managing Postsurgical Pain

    NCT06574269

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All
    Recruiting sites
    2 US recruiting sites
  14. Ketamine for Pain, Opioid Use, and Mental Health in Orthopedic Trauma Patients

    NCT06903819

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    2 US recruiting sites
  15. Continuous Infusions vs Scheduled Bolus Infusions

    NCT03230565

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    1 US recruiting site
  16. Liposomal Bupivacaine Versus Plain Bupivacaine After Intercostal Injections For Pain Management After Thoracoscopy

    NCT03737292

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    1 US recruiting site
  17. Post-Op Pain Control for Prophylactic Intramedullary Nailing.

    NCT03823534

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    1 US recruiting site
  18. Opioids Versus Non-Opioids Postoperative After Knee Arthroscopic Surgery

    NCT03858231

    • Phase 4
    • Ages 18 to 80 years
    • Sex: All
    Recruiting sites
    1 US recruiting site
  19. Optimizing Pain Control in Transurethral Resection of the Prostate

    NCT04102566

    • Phase 4
    • Ages 18 years and older
    • Sex: Male
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  20. Pulsed Electromagnetic Field (PEMF) Therapy for Post-operative Pain Following Orthopedic Surgery

    NCT04109638

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    1 US recruiting site
  21. Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain

    NCT04144972

    • Interventional
    • Ages 22 to 80 years
    • Sex: All
    Recruiting sites
    1 US recruiting site
  22. Ketamine for Post-operative Analgesia in Hemorrhoidectomy

    NCT04248205

    • Phase 4
    • Ages 18 to 100 years
    • Sex: All
    Recruiting sites
    1 US recruiting site
  23. Dextenza in the Post-op Management of Vitreoretinal Surgeries

    NCT04371445

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    1 US recruiting site
  24. fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

    NCT04439552

    • Observational
    • Ages 8 to 35 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  25. Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children

    NCT04724252

    • Phase 2/3
    • Ages Up to 17 years
    • Sex: All
    Recruiting sites
    1 US recruiting site
  26. The Pericapsular Nerve Block in Total Hip Arthroplasty

    NCT04729686

    • Phase 4
    • Ages 18 to 80 years
    • Sex: All
    Recruiting sites
    1 US recruiting site
  27. Erector Spinae Plane Block Catheters and Intrathecal Morphine for Hepatic Resection

    NCT04849455

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    1 US recruiting site
  28. Efficacy of Preoperative Administration of Gabapentin in 3rd Molar Dental Extraction.

    NCT04860141

    • Phase 4
    • Ages 18 to 59 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  29. Virtual Reality and Olfactory Stimuli Multimodal Intervention to Reduce Post-Operative Pain and Anxiety in Patients Undergoing Cardiothoracic Surgery

    NCT04912531

    • Interventional
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    1 US recruiting site
  30. Lumbar Steroid Use in Patients Undergoing Posterior Lumbar Decompression

    NCT05058287

    • Phase 3
    • Ages 18 to 85 years
    • Sex: All
    Recruiting sites
    1 US recruiting site

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Post-Surgical Pain clinical trials by city

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Post-Surgical Pain clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.