Comparing Analgesic Regimen Effectiveness and Safety for Surgery (CARES) Trial
NCT05722002
This study is recruiting at 6 US sites in 5 states, according to its ClinicalTrials.gov record last updated .
Summary
This trial is being completed to compare two commonly used options to treat pain after surgery. Participants that undergo gallbladder removal, hernia repair, and breast lump removal will be eligible to enroll. Eligible participants will be randomized to 1 of 2 groups of medications (Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) plus acetaminophen or low dose opioids plus acetaminophen). It is anticipated that the NSAID group will have superior clinical outcomes and fewer side effects when compared to the opioid group.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Surgery
- Pain, Postoperative
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 4
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- University of Michigan
- Last updated on ClinicalTrials.gov
- August 28, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Michigan · 2
- University of Michigan · Ann Arbor, MI
- Henry Ford Health System · Detroit, MI
Missouri · 1
- Washington University in Saint Louis · St Louis, MO
New Jersey · 1
- Cooper University Health Care · Camden, NJ
North Carolina · 1
- University of North Carolina Hospitals · Chapel Hill, NC
Pennsylvania · 1
- Temple University - Temple Health · Philadelphia, PA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.