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Breast Cancer Clinical Trials near Durham, NC

83 studies for Breast Cancer are recruiting at 126 sites within 50 miles of Durham, North Carolina, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Breast Cancer trials in the US or all trials near Durham.

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Recruiting now

Breast Cancer studies enrolling near Durham

Showing the 50 nearest of 83 studies.
  1. Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

    NCT05879926

    • Phase 3
    • Ages 18 to 60 years
    • Sex: Female

    Nearest sites: Duke University Medical Center (Durham, NC); UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    13 sites within 50 mi
  2. Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

    NCT05812807

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Duke University Medical Center (Durham, NC); UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    8 sites within 50 mi
  3. Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

    NCT05564377

    • Phase 2
    • Ages Any age
    • Sex: All

    Nearest sites: Duke University Medical Center (Durham, NC); Duke Women's Cancer Care Raleigh (Raleigh, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  4. ShortStop-HER2: 12 Months vs. 6 Months of HER2-targeted Medications for People With HER2+ Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Trastuzumab

    NCT06876714

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Duke University Medical Center (Durham, NC); UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  5. Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial

    NCT07391774

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Duke University Medical Center (Durham, NC); Duke Cancer Center Cary (Cary, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  6. Weight Management After Cancer for Survivors in Rural Communities

    NCT07426952

    • Interventional
    • Ages 18 years and older
    • Sex: Female

    Nearest sites: Duke University Medical Center (Durham, NC); Maria Parham Cancer Center (Henderson, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  7. Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice in Patients With Triple Negative Breast Cancer Who Have Residual Invasive Disease After Surgery and Neoadjuvant Therapy (ASCENT-05/AFT-65 OptimICE-RD/GBG 119/NSABP B-63)

    NCT05633654

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Duke Cancer Institute (Durham, NC); Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  8. A Study Comparing the Efficacy and Safety of Zanidatamab to Trastuzumab, Each in Combination With Physician's Choice Chemotherapy, for the Treatment of Participants With Metastatic HER2-positive Breast Cancer

    NCT06435429

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Duke Cancer Institute (Durham, NC); UNC Central Investigational Drug Services (Morrisville, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  9. The Vanguard Study: Testing a New Way to Screen for Cancer

    NCT06995898

    • Interventional
    • Ages 45 to 75 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest sites: Durham VA Medical Center (Durham, NC); UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  10. A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer

    NCT03424005

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  11. The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

    NCT04585750

    • Phase 1/2
    • Ages 12 years and older
    • Sex: All

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  12. Study to Assess Adverse Events and Pharmacokinetics in Adult Participants With Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma and Other Solid Tumors, Receiving Intravenous Infusion of Azirkitug Alone or in Combination(s) With Budigalimab, Bevacizumab, or Telisotuzumab Adizutecan

    NCT05005403

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute /ID# 276267 (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  13. Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

    NCT05315700

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  14. Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

    NCT05334069

    • Observational
    • Ages 40 to 75 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Durham VA Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

    NCT05696626

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  16. Open-Label Study to Evaluate the Safety, Tolerability, PK, and Efficacy of INX-315 in Patients With Advanced Cancer

    NCT05735080

    • Phase 1/2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Center/ DUMC (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  17. Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

    NCT05827081

    • Phase 3
    • Ages 18 to 100 years
    • Sex: All

    Nearest site: Duke Cancer Network (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  18. Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers

    NCT05846789

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400

    NCT06084481

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Center /ID# 255129 (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

    NCT06120283

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. DATO-BASE: DATOpotamab-deruxtecan for Breast Cancer Brain metAstaSEs

    NCT06176261

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. A Phase 1/1b Study of IAM1363 in HER2 Cancers

    NCT06253871

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  23. Optimizing Surgical Decisions in Young Adults With Breast Cancer

    NCT06275126

    • Interventional
    • Ages 18 to 44 years
    • Sex: Female

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. Symptom Management and Transitioning to Engagement With Post-treatment Care for Adolescent and Young Adult Cancer Survivors

    NCT06371768

    • Interventional
    • Ages 18 to 39 years
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

    NCT06492616

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Identifying Patterns in the Breath of Individuals With Breast Cancer

    NCT06512350

    • Observational
    • Ages 40 to 74 years
    • Sex: Female
    • Accepts healthy volunteers

    Nearest site: Duke University Medical Cente (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. Engage Psychosocial Intervention for Cancer Symptoms

    NCT06555588

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Network (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. Planning Grant for TOPS for Breast Cancer Survivors

    NCT06658912

    • Interventional
    • Ages 21 to 90 years
    • Sex: Female

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

    NCT06778863

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. A Study Evaluating the Efficacy and Safety of Inavolisib Plus CDK4/6 Inhibitor and Letrozole vs Placebo + CDK4/6i and Letrozole in Participants With Endocrine-Sensitive PIK3CA-Mutated, Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer

    NCT06790693

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. Targeted Palliative Care Intervention for Patients With Metastatic Breast Cancer

    NCT06795529

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. A Study of PHST001 in Advanced Solid Tumors

    NCT06840886

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  33. A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

    NCT06926868

    • Phase 2/3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. Patient Navigation for HER2+ Metastatic Breast Cancer Patients Treated With Tucatinib

    NCT06983691

    • Interventional
    • Ages 18 years and older
    • Sex: Female

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

    NCT07007559

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  36. Palazestrant in Combination With Ribociclib for the First-line Treatment of ER+/HER2- Advanced Breast Cancer

    NCT07085767

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Clinical Trial Site (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. Asciminib in HER2+ Breast Cancer Brain Metastases

    NCT07136428

    • Phase 1/2
    • Ages 18 years and older
    • Sex: Female

    Nearest site: Duke University (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

    NCT07213791

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke University Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  39. Assessment of Topical Minoxidil on Intraoperative Flap Perfusion and Cutaneous Flap Viability in Breast Recon

    NCT07264790

    • Phase 1
    • Ages 18 years and older
    • Sex: Female

    Nearest site: Duke Health (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. Behavioral Pain Intervention for Older Cancer Patients

    NCT07300995

    • Interventional
    • Ages 55 years and older
    • Sex: Female

    Nearest site: Duke Cancer Network (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  41. Increasing Germline Genetic Testing for Patients With Cancer

    NCT07307664

    • Interventional
    • Ages Any age
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Durham VA Medical Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  42. A Study of a Decision Tool for People Considering Breast Reconstruction Surgery

    NCT07335354

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Duke Cancer Institute (Data collection only) (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. Radiation Therapy and Thymus Function in Young Women With Breast Cancer

    NCT07725172

    • Observational
    • Ages 18 to 50 years
    • Sex: Female

    Nearest site: Duke Cancer Center (Durham, NC)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  44. Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer

    NCT06058377

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC); University of North Carolina-Hillsborough Campus (Hillsborough, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    6 sites within 50 mi
  45. Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

    NCT05929768

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC); University of North Carolina-Hillsborough Campus (Hillsborough, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  46. Harnessing Analysis RNA Expression and Molecular Subtype to Optimize Novel TherapY MBCA

    NCT03769415

    • Interventional
    • Ages 18 to 99 years
    • Sex: All

    Nearest sites: UNC Lineberger Comprehensive Cancer Center (Chapel Hill, NC); UNC Rex Healthcare (Raleigh, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  47. Correlation of Molecular Markers With Response to Therapy and Breast Cancer Behavior

    NCT01000883

    • Observational
    • Ages 18 years and older
    • Sex: All

    Nearest site: Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  48. SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

    NCT03452774

    • Observational
    • Ages Any age
    • Sex: All

    Nearest site: Massive Bio SYNERGY-AI site (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  49. Sacituzumab Govitecan +/- Pembrolizumab in Metastatic TNBC

    NCT04468061

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: The University of North Carolina at Chapel Hill (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  50. CD40 Agonist, Flt3 Ligand, and Chemotherapy in HER2 Negative Breast Cancer

    NCT05029999

    • Phase 1
    • Ages 18 to 99 years
    • Sex: All

    Nearest site: University of North Carolina (Chapel Hill, NC)

    Distance to nearest recruiting site
    ~10 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Breast Cancer clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.