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Depression Clinical Trials near St Louis, MO

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27 studies for Depression are recruiting at 34 sites within 50 miles of St Louis, Missouri, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Depression trials in the US or all trials near St Louis.

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Recruiting now

Depression studies enrolling near St Louis

Showing 27 studies, nearest first.
  1. E-Mindfulness Approaches for Living After Breast Cancer

    NCT06748222

    • Phase 3
    • Ages 18 to 50 years
    • Sex: All

    Nearest sites: Mercy Hospital Saint Louis (St Louis, MO); Mercy Hospital South (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  2. A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    NCT03887715

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Washington University School of Medicine (St Louis, MO); Psychiatric Care and Research (O'Fallon, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  3. NMDA Receptor Antagonist Nitrous Oxide Targets Affective Brain Circuits

    NCT02994433

    • Phase 1
    • Ages 18 to 65 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Washington University School of Medicine (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  4. Brain Stimulation for Severe Depression

    NCT05393622

    • Interventional
    • Ages 21 to 80 years
    • Sex: All

    Nearest site: Washington University in St Louis School of Medicine (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  5. Depression and Driving

    NCT05446805

    • Observational
    • Ages 65 years and older
    • Sex: All

    Nearest site: Washington University School of Medicine (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  6. Efficacy of a Multi-level School Intervention for LGBTQ Youth

    NCT05541406

    • Interventional
    • Ages 12 to 20 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Washington University in St. Louis (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  7. Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

    NCT05905705

    • Observational
    • Ages 21 to 65 years
    • Sex: All

    Nearest site: Washington University School of Medicine/Barnes-Jewish Hospital (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  8. Study of ALTO-300 in MDD

    NCT05922878

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Site 264 (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  9. Type I Hybrid Effectiveness-Implementation Trial of Primary Care Brief Mindfulness Training for Veterans

    NCT06162741

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: St. Louis VA Medical Center John Cochran Division, St. Louis, MO (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  10. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    NCT06423430

    • Interventional
    • Ages 22 to 70 years
    • Sex: All

    Nearest site: Washington University School of Medicine (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  11. Slow Wave Induction by Propofol to Eliminate Depression (SWIPED) Stage II

    NCT06867549

    • Phase 2
    • Ages 60 years and older
    • Sex: All

    Nearest site: Washington University School of Medicine/Barnes-Jewish Hospital (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  12. Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

    NCT06978166

    • Interventional
    • Ages 45 years and older
    • Sex: All

    Nearest site: Washington University in St. Louis School of Medicine (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  13. A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

    NCT07065240

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Seaport Investigator Site (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  14. A Study of Brenipatide in Adult Participants With Major Depressive Disorder

    NCT07412756

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: Arch Clinical Trials (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. ALTO-207 in Adults With Treatment-resistant Depression (TRD)

    NCT07553637

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: Site 7189 (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  16. A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

    NCT07592689

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest site: Arch Clinical Trials, LLC (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  17. Lumateperone for Late-Life Depression

    NCT07623135

    • Phase 3
    • Ages 60 years and older
    • Sex: All

    Nearest site: Washington University School of Medicine (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  18. Leveraging mHealth to Promote Opioid Use Recovery and Mental Health Among Residents of a Medium-Sized Midwestern City

    NCT07673380

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Washington University School of Medicine (St Louis, MO)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06966401

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Saint Charles, MO); Neurocrine Clinical Site (O'Fallon, MO)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  20. Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

    NCT07226661

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest sites: Midwest Research Group (Saint Charles, MO); Psychiatric Care and Research Center (O'Fallon, MO)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  21. A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

    NCT06223880

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Clinical Research Site (Saint Charles, MO)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

    NCT06372964

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All

    Nearest site: Midwest Research Group (Saint Charles, MO)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  23. Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

    NCT06633016

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Autobahn Site #127 (Saint Charles, MO)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

    NCT06830044

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Vanda Investigational Site (Saint Charles, MO)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

    NCT07284667

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: St. Charles Psychiatric Associates, Inc. dba Midwest Research Group (Saint Charles, MO)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

    NCT05850689

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Psychiatric Care and Research Center (PCRC) (O'Fallon, MO)

    Distance to nearest recruiting site
    ~30 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT07196501

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Neurocrine Clinical Site (O'Fallon, MO)

    Distance to nearest recruiting site
    ~30 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Depression clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.