Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)
NCT06423430
This study is recruiting at 23 US sites in 17 states, according to its ClinicalTrials.gov record last updated .
Summary
The goal of this clinical trial is to evaluate the effectiveness and safety of bilateral stimulation of the subcallosal cingulate white matter (SCCwm) using Deep Brain Stimulation (DBS) as an adjunctive treatment of non-psychotic unipolar Major Depressive Disorder (MDD) in adults.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Treatment Resistant Depression
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Not applicable
- Ages
- 22 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Abbott Medical Devices
- Last updated on ClinicalTrials.gov
- August 28, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama at Birmingham - Dept. of Psychiatry · Birmingham, AL
California · 2
- UCLA Department of Psychiatry · Los Angeles, CA
- University of California at Davis · Sacramento, CA
Florida · 1
- USF Health · Tampa, FL
Georgia · 1
- Emory University Hospital · Atlanta, GA
Illinois · 1
- Rush University Medical Center · Chicago, IL
Indiana · 1
- Indiana University · Indianapolis, IN
Massachusetts · 2
- Beth Israel Deaconess Medical Center · Boston, MA
- Massachusetts General Hospital · Boston, MA
Minnesota · 1
- Mayo Clinic · Rochester, MN
Missouri · 1
- Washington University School of Medicine · St Louis, MO
New Jersey · 1
- Robert Wood Johnson University Hospital · New Brunswick, NJ
New York · 1
- Mount Sinai Hospital · New York, NY
Ohio · 2
- The Cleveland Clinic Foundation · Cleveland, OH
- The Ohio State University · Columbus, OH
Pennsylvania · 1
- Pennsylvania Hospital · Philadelphia, PA
South Carolina · 1
- Medical University of South Carolina · Charleston, SC
Texas · 4
- University of Texas Austin Dell Medical School · Austin, TX
- University of Texas Southwestern Medical Center at Dallas · Dallas, TX
- CHI St. Luke's Health Baylor College of Medicine Med. Ctr · Houston, TX
- The Methodist Hospital · Houston, TX
Utah · 1
- University of Utah Hospital · Salt Lake City, UT
Wisconsin · 1
- Medical College of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.