Skip to content
Trial Eligibility
Menu

Depression Clinical Trials near Philadelphia, PA

Illustration: A person opening curtains to let warm morning sunlight into a quiet bedroom, a plant on the sill
Illustration of Philadelphia, PA

46 studies for Depression are recruiting at 61 sites within 50 miles of Philadelphia, Pennsylvania, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Depression trials in the US or all trials near Philadelphia.

Your ZIP is looked up in your browser. We don't receive or store it.

Recruiting now

Depression studies enrolling near Philadelphia

Showing 46 studies, nearest first.
  1. Foundational Programs to Combat Clinician Stress

    NCT07220421

    • Interventional
    • Ages 25 to 70 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest sites: Hospital of the University of Pennsylvania (Philadelphia, PA); Penn Presbyterian Medical Center (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  2. A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

    NCT07775300

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Adams Clinical Philadelphia (Philadelphia, PA); Penn Medicine: University of Pennsylvania Health System (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  3. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    NCT06793397

    • Phase 3
    • Ages 18 to 85 years
    • Sex: All

    Nearest sites: Adams Clinical Philadelphia (Philadelphia, PA); Flourish Research Philadelphia (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  4. A Study of Brenipatide in Adult Participants With Major Depressive Disorder

    NCT07412756

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Penn Medicine: University of Pennsylvania Health System (Philadelphia, PA); Suburban Research Associates (West Chester, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  5. A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

    NCT07573176

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest sites: University of Pennsylvania (Philadelphia, PA); CenExel Marlton NJ (Marlton, NJ)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  6. Evaluation of the PACE/PACENET BHL Clinical Program

    NCT02463266

    • Observational
    • Ages 65 years and older
    • Sex: All

    Nearest site: Department of Psychiatry (Center for Psychotherapy Research), University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  7. Decoding and Modulating Affective Brain States

    NCT05437705

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  8. Triage Survey for Psychiatry Research Eligibility

    NCT05800925

    • Observational
    • Ages 18 years and older
    • Sex: All

    Nearest site: Adams Clinical, Philadelphia (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  9. Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

    NCT05850689

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: University of Pennsylvania - Perelman School of Medicine (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  10. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    NCT06423430

    • Interventional
    • Ages 22 to 70 years
    • Sex: All

    Nearest site: Pennsylvania Hospital (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  11. Antidepressant Adherence for Depressed Adults in Primary Care

    NCT06496646

    • Interventional
    • Ages 21 to 64 years
    • Sex: All

    Nearest site: University of Pennsylvania Health System (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  12. Postpartum Care in the NICU (PeliCaN) Transitions

    NCT06521398

    • Interventional
    • Ages 16 years and older
    • Sex: Female

    Nearest site: Hospital of the University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  13. Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

    NCT06559306

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest site: University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  14. Taking Action for College Students

    NCT06700902

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Temple University (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. Pilot Study: Establishing Glutamatergic Changes in Rapid Antidepressant Effects of Ketamine

    NCT06788249

    • Early Phase 1
    • Ages 25 to 65 years
    • Sex: All

    Nearest site: University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  16. Get ActivE Study for At-risk Youth

    NCT06829953

    • Interventional
    • Ages 12 to 18 years
    • Sex: All

    Nearest site: Children's Hospital of Philadelphia (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  17. RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV

    NCT06906302

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: VA Philadelphia Healthcare System (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  18. NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06963021

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Neurocrine Clinical Site (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Transdiagnostic Sleep and Circadian Intervention + Bright Light in Adolescents With Elevated Depression (TranS-C+BL)

    NCT06963463

    • Interventional
    • Ages 12 to 18 years
    • Sex: All

    Nearest site: Childrens Hospital of Philadelphia (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06966401

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Neurocrine Clinical Site (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

    NCT07002034

    • Phase 2
    • Ages 18 to 80 years
    • Sex: All

    Nearest site: University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. Telehealth Collaborative Care Model (CoCM) in Lung Cancer

    NCT07102147

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Abramson Cancer Center at the University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  23. A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    NCT07115329

    • Phase 2
    • Ages 18 to 64 years
    • Sex: All

    Nearest site: Adams Clinical (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. Neurofeedback to Treat Depression - 2

    NCT07159061

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Center for Neuromodulation in Depression and Stress (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. A Study to Evaluate the Maintenance Effect of Osavampator as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT07196501

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Neurocrine Clinical Site (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression

    NCT07226232

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. Evaluate the Effects of Long-term Use of Psychotropic Medications on Eye Movement Patterns With the Gaize Device

    NCT07389473

    • Observational
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Gaize (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. ACT With CF Self-Help Toolkit

    NCT07436351

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Thomas Jefferson University Hospital (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

    NCT07592689

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest site: Adams Clinical Philadelphia (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. Removing Surrogates Uncertainty to Reduce Fear and Anxiety After Cardiac Events - Kids

    NCT07707037

    • Interventional
    • Ages 0 days to 17 years
    • Sex: All

    Nearest site: Children's Hospital of Philadelphia (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. Precision Depression Adalimumab Trial

    NCT07845604

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: University of Pennsylvania (Philadelphia, PA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. E-Mindfulness Approaches for Living After Breast Cancer

    NCT06748222

    • Phase 3
    • Ages 18 to 50 years
    • Sex: All

    Nearest sites: Cooper Hospital University Medical Center (Camden, NJ); UPMC Hillman Cancer Center - Part of Frick Hospital (Mount Pleasant, PA)

    Distance to nearest recruiting site
    ~3 mi (city-level)
    Recruiting sites
    7 sites within 50 mi
  33. A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

    NCT06223880

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Clinical Research Site (Cherry Hill, NJ)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

    NCT07484217

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Clinical Research Site (Cherry Hill, NJ)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

    NCT07610473

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Draig Clinical Site (Media, PA); Draig Clinical Site (Allentown, PA)

    Distance to nearest recruiting site
    ~12 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  36. Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

    NCT07226661

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Cenexel Marlton (HRI) (Marlton, NJ)

    Distance to nearest recruiting site
    ~14 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

    NCT07300969

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: Draig Clinical Site (Marlton, NJ)

    Distance to nearest recruiting site
    ~14 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

    NCT06633016

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Autobahn Site #129 (Berlin, NJ)

    Distance to nearest recruiting site
    ~17 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  39. Retrospective Analyses of TrakStar Database

    NCT06917339

    • Observational
    • Ages 5 to 120 years
    • Sex: All

    Nearest site: Neuronetics (Malvern, PA)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. Retrospective Analyses of the Greenbrook Database Evaluating Mental Health Treatments

    NCT06997549

    • Observational
    • Ages 5 to 100 years
    • Sex: All

    Nearest site: Neuronetics (Malvern, PA)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  41. Morphine or Ketamine for Analgesia

    NCT06835504

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All

    Nearest site: Nemours Children's Hospital (Wilmington, DE)

    Distance to nearest recruiting site
    ~25 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  42. Positive Processes and Transition to Health (PATH)

    NCT06093906

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: University of Delaware (Newark, DE)

    Distance to nearest recruiting site
    ~36 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults

    NCT06860724

    • Interventional
    • Ages 18 to 55 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: University of Delaware (Newark, DE)

    Distance to nearest recruiting site
    ~36 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  44. Brexanolone Lifting Outcomes Of Moms

    NCT07822321

    • Phase 3
    • Ages 15 to 45 years
    • Sex: Female

    Nearest site: Lipocine Investigational Site (Princeton, NJ)

    Distance to nearest recruiting site
    ~38 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  45. Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    NCT06547489

    • Phase 2
    • Ages 18 to 64 years
    • Sex: All

    Nearest site: Lehigh Center for Clinical Research (Allentown, PA)

    Distance to nearest recruiting site
    ~49 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  46. A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

    NCT07065240

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Seaport Investigator Site (Allentown, PA)

    Distance to nearest recruiting site
    ~49 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Depression clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.