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Depression Clinical Trials near Orange, CA

60 studies for Depression are recruiting at 150 sites within 50 miles of Orange, California, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Depression trials in the US or all trials near Orange.

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Depression studies enrolling near Orange

Showing the 50 nearest of 60 studies.
  1. E-Mindfulness Approaches for Living After Breast Cancer

    NCT06748222

    • Phase 3
    • Ages 18 to 50 years
    • Sex: All

    Nearest sites: UC Irvine Health/Chao Family Comprehensive Cancer Center (Orange, CA); Kaiser Permanente-Anaheim (Anaheim, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    17 sites within 50 mi
  2. A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

    NCT04777357

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All

    Nearest sites: CHOC Children's Hospital /ID# 260298 (Orange, CA); Advanced Research Center /ID# 227073 (Anaheim, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    6 sites within 50 mi
  3. Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

    NCT06633016

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Autobahn Site #152 (Orange, CA); Autobahn Site #150 (Anaheim, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    6 sites within 50 mi
  4. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    NCT06793397

    • Phase 3
    • Ages 18 to 85 years
    • Sex: All

    Nearest sites: ATP Clinical Research (Orange, CA); NRC Research Institute (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    6 sites within 50 mi
  5. Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06966401

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Orange, CA); Neurocrine Clinical Site (Pico Rivera, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  6. A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

    NCT07573176

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest sites: NRC Research Institute (Orange, CA); CI Trials (Bellflower, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  7. A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

    NCT07105111

    • Phase 4
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Orange, CA); Neurocrine Clinical Site (Chino, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  8. Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06786624

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Orange, CA); Neurocrine Clinical Site (Pico Rivera, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  9. Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

    NCT06830044

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Vanda Investigational Site (Orange, CA); Vanda Investigational Site (Garden Grove, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  10. ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

    NCT07284667

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: PNS Clinical Research LLC dba ATP Clinical Research (Orange, CA); Inland Psychiatric Medical Group (Chino, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  11. A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

    NCT07621237

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Nrc Research Institute (Orange, CA); Buena Park Research Center (Buena Park, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  12. A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT07196501

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Orange, CA); Neurocrine Clinical Site (Oceanside, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  13. TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

    NCT07048574

    • Observational
    • Ages 18 months to 11 years
    • Sex: All

    Nearest site: Children's Hospital of Orange County (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  14. A Study of Brenipatide in Adult Participants With Major Depressive Disorder

    NCT07412756

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: ATP Clinical Research (Orange, CA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

    NCT06559306

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest sites: PAMOJA Clinical Institute LLC (Anaheim, CA); Behavioral Research Specialists LLC (Glendale, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  16. A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

    NCT07276997

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Advanced Research Center /ID# 277537 (Anaheim, CA); Accellacare - Long Beach /ID# 279181 (Long Beach, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  17. Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

    NCT06372964

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All

    Nearest sites: Advanced Research Center, Inc (Anaheim, CA); Next Level Clinical Trials, LLC (West Covina, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  18. A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

    NCT06524830

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: CenExel (Garden Grove, CA); Collaborative Neuroscience Research, LLC (Los Alamitos, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  19. A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

    NCT07065240

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Seaport Investigator Site (Garden Grove, CA); Seaport Investigator Site (Chino, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  20. Double-blind, Placebo-controlled Study in Adults With Major Depressive Disorder

    NCT07226661

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Collaborative Neuroscience Network (Garden Grove, CA)

    Distance to nearest recruiting site
    ~5 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    NCT06547489

    • Phase 2
    • Ages 18 to 64 years
    • Sex: All

    Nearest sites: Irvine Clinical Research (Irvine, CA); CalNeuro Research Group (Los Angeles, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  22. A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

    NCT07775300

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Irvine Clinical Research (Irvine, CA); Concierge Clinical Trials (Valley Village, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  23. Positive Affect Treatment for Adolescents With Early Life Adversity

    NCT06273137

    • Interventional
    • Ages 12 to 16 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: University of California Irvine (Irvine, CA)

    Distance to nearest recruiting site
    ~8 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    NCT03887715

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: ATP Clinical Research, Inc. (Costa Mesa, CA); Keck Hospital of USC (Los Angeles, CA)

    Distance to nearest recruiting site
    ~11 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  25. A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

    NCT07610473

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Draig Clinical Site (Costa Mesa, CA); Draig Clinical Site (Bellflower, CA)

    Distance to nearest recruiting site
    ~11 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  26. SAINT® Therapy for Memory Problems in Older Adults With Treatment-Resistant Depression

    NCT07876908

    • Interventional
    • Ages 65 years and older
    • Sex: All

    Nearest site: BrainHealth Solutions Inc. (Costa Mesa, CA)

    Distance to nearest recruiting site
    ~11 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. ATLAS-1: Advanced Trial for Longitudinal Assessment in Salma 1

    NCT07528014

    • Observational
    • Ages 18 years and older
    • Sex: All

    Nearest site: Salma Health (Laguna Hills, CA)

    Distance to nearest recruiting site
    ~15 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

    NCT07484217

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Clinical Research Site (Bellflower, CA); Clinical Research Site (Chino, CA)

    Distance to nearest recruiting site
    ~17 mi (city-level)
    Recruiting sites
    7 sites within 50 mi
  29. Study of ALTO-300 in MDD

    NCT05922878

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest sites: Site 218 (Bellflower, CA); Site 194 (Mission Viejo, CA)

    Distance to nearest recruiting site
    ~17 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  30. A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

    NCT06223880

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Clinical Research Site (Bellflower, CA); Clinical Research Site (Upland, CA)

    Distance to nearest recruiting site
    ~17 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  31. ALTO-100 in Bipolar Disorder With Depression (BD-D)

    NCT06656416

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest sites: Site 6153 (Chino, CA); 6069 (Los Angeles, CA)

    Distance to nearest recruiting site
    ~18 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  32. NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06963021

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Chino, CA); Neurocrine Clinical Site (Los Angeles, CA)

    Distance to nearest recruiting site
    ~18 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  33. Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

    NCT05850689

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: CNRI-Los Angeles, LLC (Pico Rivera, CA)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    NCT07115329

    • Phase 2
    • Ages 18 to 64 years
    • Sex: All

    Nearest sites: Catalina Research Institute, LLC (Montclair, CA); Anderson Clinical Research (Redlands, CA)

    Distance to nearest recruiting site
    ~22 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  35. A Study to Evaluate the Effectiveness of DT-101 in Patients With Depression

    NCT07300969

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Draig Clinical Site (Torrance, CA); Draig Clinical Site (Oceanside, CA)

    Distance to nearest recruiting site
    ~28 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  36. Pain and Major Depressive Disorder

    NCT04556890

    • Interventional
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: UCLA Semel Institute (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. Model-based Electrical Brain Stimulation

    NCT05327387

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: University of Southern California (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression

    NCT05329441

    • Observational
    • Ages 14 to 21 years
    • Sex: All

    Nearest site: University of California, Los Angeles (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  39. S.T.A.N.D. Alacrity Center Signature Project

    NCT05591937

    • Interventional
    • Ages 18 to 40 years
    • Sex: All

    Nearest site: East Los Angeles College (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. Evaluating tDCS Brain-stimulation in Depression Using MRI

    NCT05598034

    • Interventional
    • Ages 20 to 55 years
    • Sex: All

    Nearest site: University of California Los Angeles (UCLA) (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  41. In-patient SCC TMS

    NCT05645575

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: UCLA TMS Service and Research Service (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  42. Acceptance and Commitment Therapy for Adolescents and Young Adults With Sickle Cell Disease

    NCT05685368

    • Phase 1/2
    • Ages 14 to 21 years
    • Sex: All

    Nearest site: Children's Hospital Los Angeles (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. Project 2: Optimizing Engagement and Outcomes in STAND Digital Therapy

    NCT05908565

    • Interventional
    • Ages 18 to 40 years
    • Sex: All

    Nearest site: East Los Angeles College (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  44. Better Sleep Study

    NCT06139861

    • Interventional
    • Ages 12 to 18 years
    • Sex: All

    Nearest site: Children's Hospital Los Angeles (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  45. Regulation of Affect and Physiology in Depression

    NCT06345859

    • Phase 2
    • Ages 18 to 27 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: University of Southern California (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  46. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    NCT06423430

    • Interventional
    • Ages 22 to 70 years
    • Sex: All

    Nearest site: UCLA Department of Psychiatry (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  47. Assessing Improvements in Mood and Sleep Trial

    NCT06639477

    • Interventional
    • Ages 55 years and older
    • Sex: All

    Nearest site: The Regents of the University of California, Los Angeles (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  48. Improving Behavioral Health for Caregivers and Children After Pediatric Injury

    NCT06856057

    • Interventional
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Children's Hospital Los Angeles (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  49. RCT for Latina Mental Health Using Web-Based Apps

    NCT06874790

    • Interventional
    • Ages 18 years and older
    • Sex: Female
    • Accepts healthy volunteers

    Nearest site: UCLA (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  50. A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression

    NCT06906939

    • Early Phase 1
    • Ages 50 to 95 years
    • Sex: All

    Nearest site: UCLA Semel Institute - Neuropsychiatric Institute (NPI) (Los Angeles, CA)

    Distance to nearest recruiting site
    ~29 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Depression clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.