Skip to content
Trial Eligibility
Menu

Depression Clinical Trials near Houston, TX

45 studies for Depression are recruiting at 63 sites within 50 miles of Houston, Texas, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Depression trials in the US or all trials near Houston.

Your ZIP is looked up in your browser. We don't receive or store it.

Recruiting now

Depression studies enrolling near Houston

Showing 45 studies, nearest first.
  1. A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

    NCT04777357

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All

    Nearest sites: Kaleidoscope Clinical Research /ID# 277650 (Houston, TX); Houston Clinical Trials - Bellaire /ID# 274189 (Bellaire, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    5 sites within 50 mi
  2. Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06966401

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Houston, TX); Neurocrine Clinical Site (Bellaire, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    4 sites within 50 mi
  3. ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response

    NCT07284667

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Baylor College of Medicine (Houston, TX); Olympus Clinical Research, LLC (Katy, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  4. Survivorship Care for Women Living With Ovarian Cancer: (POSTCARE-O)

    NCT05752448

    • Interventional
    • Ages 18 years and older
    • Sex: Female

    Nearest sites: Dan L Duncan Comprehensive Cancer Center at the O'Quinn Medical Tower at Baylor St. Luke's Medical Center (Houston, TX); Harris Health Smith Clinic (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  5. Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

    NCT06372964

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All

    Nearest sites: Kaleidoscope Clinical Research (Houston, TX); Perceptive Pharma Research (Richmond, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  6. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    NCT06423430

    • Interventional
    • Ages 22 to 70 years
    • Sex: All

    Nearest sites: CHI St. Luke's Health Baylor College of Medicine Med. Ctr (Houston, TX); The Methodist Hospital (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  7. Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression

    NCT06480201

    • Phase 1
    • Ages 21 to 45 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest sites: Texas A&M (Houston Methodist Hospital Location) (Houston, TX); Wells Medicine (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  8. Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

    NCT06559306

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest sites: Baylor College of Medicine (Houston, TX); Houston Clinical Trials LLC (Bellaire, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  9. Neurobehavioral Therapy For Epilepsy And Major Depressive Disorder

    NCT06695767

    • Interventional
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest sites: Michael E. DeBakey VA Medical Center (Houston, TX); The University of Texas health Science Center at Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  10. Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

    NCT07484217

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Clinical Research Site (Houston, TX); Clinical Research Site (Bellaire, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  11. Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression

    NCT03522545

    • Phase 1
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: The University of Texas Health Science Center at Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  12. A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    NCT03887715

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: The University Of Texas Medical School At Houston - UT Center Of Excellence On Mood Disorders (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  13. Mapping and Modulating the Spatiotemporal Dynamics of Socio-Affective Processing

    NCT05418894

    • Interventional
    • Ages 22 to 70 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Baylor College of Medicine (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  14. Cortical rTMS as a Treatment for Depression

    NCT05487911

    • Interventional
    • Ages 18 to 64 years
    • Sex: All

    Nearest site: The Menninger Clinic (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. Functional Connectivity Alterations in Suicidal Patients Among Opioid Users

    NCT05489042

    • Interventional
    • Ages 18 to 64 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: The Menninger Clinic (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  16. Neurodevelopmental Outcomes in Children: Strengthening the Caregiver-Child Story

    NCT05809115

    • Observational
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Texas Children's Hospital (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  17. Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

    NCT05850689

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: DM Clinical Research (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  18. Intracranial Investigation of Neural Circuity Underlying Human Mood

    NCT05871372

    • Interventional
    • Ages 21 to 70 years
    • Sex: All

    Nearest site: Baylor College of Medicine (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy

    NCT06200155

    • Phase 2
    • Ages 25 years and older
    • Sex: All

    Nearest site: MD Anderson Cancer Center (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. Improving Adult Protective Services Client Outcomes: A Stepped-Care Social and Mental Health Engagement Program

    NCT06257095

    • Interventional
    • Ages 65 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: The University of Texas Health Science Center at Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. Telehealth Behavioral Activation for Teens

    NCT06273995

    • Interventional
    • Ages 12 to 18 years
    • Sex: All

    Nearest site: Baylor College of Medicine (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

    NCT06526078

    • Interventional
    • Ages 18 to 80 years
    • Sex: All

    Nearest site: Baylor College of Medicine (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  23. Deep Brain Stimulation of Treatment-Resistant Bipolar Depression

    NCT06599099

    • Interventional
    • Ages 22 to 64 years
    • Sex: All

    Nearest site: Baylor College of Medicine (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. ALTO-100 in Bipolar Disorder With Depression (BD-D)

    NCT06656416

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Site 6175 (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality

    NCT06706232

    • Phase 2
    • Ages 25 to 70 years
    • Sex: All

    Nearest site: The University of Texas Health Science Center at Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06786624

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Neurocrine Clinical Site (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    NCT06793397

    • Phase 3
    • Ages 18 to 85 years
    • Sex: All

    Nearest site: Brain Health Consultants and TMS Center (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors

    NCT06801041

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: The University of Texas M. D. Anderson Cancer Center (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

    NCT06830044

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Vanda Investigational Site (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. Improving Behavioral Health for Caregivers and Children After Pediatric Injury

    NCT06856057

    • Interventional
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Children's Memorial Hermann Hospital (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. Behavioral Activation for the PreVention of Post-strokE Depression in LoW-incomE Older Stroke Survivors

    NCT06864715

    • Interventional
    • Ages 55 years and older
    • Sex: All

    Nearest site: The University of Texas Health Science Center at Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. Leveraging Adult Protective Service Interaction to Offer Evidence-Based Treatment for Depression in Elder Neglect/Self Neglect

    NCT06910267

    • Interventional
    • Ages 65 years and older
    • Sex: All

    Nearest site: The University of Texas Health Science Center at Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  33. Expansion and Evaluation of AI-generated Clinical Assessment (AI-COA®) of Depression and Anxiety Severity

    NCT06923995

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Baylor College of Medicine (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. Self Neuro-modulation Therapy for Major Depressive Disorder (MDD) With Anhedonia

    NCT06982820

    • Interventional
    • Ages 22 to 75 years
    • Sex: All

    Nearest site: Houston Center For Advanced Psychiatric Treatment (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. Bilateral Prefrontal and Insular TMS for Depression in Schizophrenia

    NCT07060066

    • Interventional
    • Ages 18 to 60 years
    • Sex: All

    Nearest site: The University of Texas Health Science Center at Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  36. A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

    NCT07227454

    • Phase 3
    • Ages 12 to 17 years
    • Sex: All

    Nearest site: John S Dunn Behavioral Sciences Center at UTHealth Houston (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. ALTO-207 in Adults With Treatment-resistant Depression (TRD)

    NCT07553637

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: Site 7145 (Houston, TX)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT07196501

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Bellaire, TX); Neurocrine Clinical Site (Stafford, TX)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  39. PCORI Comparative Effectiveness Study-Esketamine (Spravato) vs. Ketamine-Equivalence Study

    NCT06713616

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Houston Center for Advanced Psychiatric Treatment (Bellaire, TX)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. The OBSERVE Protocol

    NCT06725277

    • Observational
    • Ages Any age
    • Sex: All

    Nearest site: Houston Center for Advanced Psychiatric Treatment (Bellaire, TX)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  41. A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

    NCT07276997

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Houston Clinical Trials - Bellaire /ID# 277551 (Bellaire, TX)

    Distance to nearest recruiting site
    ~7 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  42. A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

    NCT06223880

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Clinical Research Site (Friendswood, TX)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    NCT07115329

    • Phase 2
    • Ages 18 to 64 years
    • Sex: All

    Nearest sites: Elevate Synapsis, LLC (Atascocita, TX); Synapsis Bio (Atascocita, TX)

    Distance to nearest recruiting site
    ~20 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  44. Study of ALTO-300 in MDD

    NCT05922878

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Site 196 (Richmond, TX)

    Distance to nearest recruiting site
    ~27 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  45. A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

    NCT07775300

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: Olympus Clinical Research (Katy, TX)

    Distance to nearest recruiting site
    ~28 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Depression clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.