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Depression Clinical Trials near Chicago, IL

47 studies for Depression are recruiting at 69 sites within 50 miles of Chicago, Illinois, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Depression trials in the US or all trials near Chicago.

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Depression studies enrolling near Chicago

Showing 47 studies, nearest first.
  1. E-Mindfulness Approaches for Living After Breast Cancer

    NCT06748222

    • Phase 3
    • Ages 18 to 50 years
    • Sex: All

    Nearest sites: Northwestern University (Chicago, IL); Rush MD Anderson Cancer Center (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    16 sites within 50 mi
  2. A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    NCT03887715

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Rush University Medical Center (Chicago, IL); Psychiatric Medicine Associates, LLC (Skokie, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  3. Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

    NCT06372964

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All

    Nearest sites: Ann & Robert H. Lurie Children's Hospital of Chicago (Chicago, IL); Revive Research Institute (Elgin, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  4. Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms

    NCT06559306

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest sites: Northwestern University (Chicago, IL); Baber Research Group (Naperville, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  5. RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

    NCT07002034

    • Phase 2
    • Ages 18 to 80 years
    • Sex: All

    Nearest sites: Rush University Medical Center (Chicago, IL); University of Chicago Medical Center (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  6. A Study to Assess Change in Disease Activity and Adverse Events of Oral Icalcaprant in Adult Participants With Major Depressive Disorder

    NCT07276997

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest sites: Flourish Research - Great Lakes Clinical Trials /ID# 278201 (Chicago, IL); Amr Conventions Research /ID# 277547 (Warrenville, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  7. A Study to Evaluate the Effectiveness of DT-101 as an Adjunctive Treatment in Patients With Depression

    NCT07610473

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Draig Clinical Site (Chicago, IL); Draig Clinical Site (Skokie, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  8. Exercise Training for Managing Major Depressive Disorder in Multiple Sclerosis

    NCT05051618

    • Interventional
    • Ages 18 to 64 years
    • Sex: All

    Nearest site: University of Illinois at Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  9. Evaluating the Impact of Focused Muscle Contraction Therapy in U.S. Veterans

    NCT05094297

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: University of Illinois at Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  10. My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life

    NCT05369429

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Northwestern University (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  11. Study of ALTO-300 in MDD

    NCT05922878

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Site 310 (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  12. A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

    NCT06223880

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Clinical Research Site (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  13. Hybrid Type 1 Randomized Pilot Trial of a Peer-led Family and Social Strengthening Group Intervention for Refugee Families

    NCT06261463

    • Interventional
    • Ages 12 to 55 years
    • Sex: All

    Nearest site: University of Illinios Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  14. ACE-D Aim 3 Clinical Cognitive Trial to Enhance Translation in Depression

    NCT06408246

    • Phase 2
    • Ages 18 to 60 years
    • Sex: All

    Nearest site: University of Illinois at Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  15. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    NCT06423430

    • Interventional
    • Ages 22 to 70 years
    • Sex: All

    Nearest site: Rush University Medical Center (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  16. A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)

    NCT06524830

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Pillar Clinical Research LLC (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  17. Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

    NCT06526078

    • Interventional
    • Ages 18 to 80 years
    • Sex: All

    Nearest site: University of Illinois at Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  18. Clemastine for Improving White Matter and Boosting Antidepressant Response in Late-life Depression

    NCT06591091

    • Phase 2
    • Ages 60 years and older
    • Sex: All

    Nearest site: University of Illinois College of Medicine (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Digital InteGrated Behavioral treatmeNt for Comorbid obesITy and deprEssion Among Racial and Ethnic Adults Age 50 and Older

    NCT06636058

    • Interventional
    • Ages 50 to 74 years
    • Sex: All

    Nearest site: Department of Medicine, Vitoux Program on Aging and Prevention (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. ALTO-100 in Bipolar Disorder With Depression (BD-D)

    NCT06656416

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Site 6113 (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

    NCT06740383

    • Observational
    • Ages 18 to 40 years
    • Sex: All

    Nearest site: University of Chicago Medical Center (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    NCT06793397

    • Phase 3
    • Ages 18 to 85 years
    • Sex: All

    Nearest site: Rush University (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  23. Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

    NCT06830044

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Vanda Investigational Site (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. Test of Target Engagement of Ambiguity Aversion

    NCT06962527

    • Interventional
    • Ages 25 to 60 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Northwestern University (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. Community-based Approach to Lowering Stress Through Mindfulness

    NCT06987799

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: The Salvation Army Ray and Joan Kroc Corps Community Center Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Developing Evidence-Based Cognitive Approaches to Improve Adjustment to Vision Loss

    NCT07073521

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: The Chicago Lighthouse (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder

    NCT07115329

    • Phase 2
    • Ages 18 to 64 years
    • Sex: All

    Nearest site: EmVenio Research (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. Our Voices Matter: Intervention for Depression in Youth

    NCT07216326

    • Interventional
    • Ages 15 to 20 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Ann & Robert H. Lurie Children's Hospital of Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. Developing a Digital Intervention for Adolescent Nonsuicidal Self-injury

    NCT07224165

    • Interventional
    • Ages 14 to 18 years
    • Sex: All

    Nearest site: Northwestern University (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. CommunityRx-Dementia + Peer Navigation (CRxDpeer)

    NCT07346183

    • Interventional
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: University of Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol

    NCT07484217

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Clinical Research Site (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. Maternal Outcomes: Mood, Alcohol Use, and Depressive Symptoms

    NCT07485036

    • Interventional
    • Ages 18 years and older
    • Sex: Female

    Nearest site: University of Illinois Hospital and Health Sciences System, University of Illinois College of Medicine (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  33. The Effect of Remotely Delivered Pilates on Physical , and Psychological Outcomes in Individuals With Multiple Sclerosis

    NCT07504120

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: University of Illinois Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

    NCT07573176

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest site: Chicago Research Center (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

    NCT07592689

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest site: Uptown Research Institute (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  36. Parents and Babies Pilot

    NCT07607613

    • Interventional
    • Ages 18 years and older
    • Sex: Female

    Nearest site: Northwestern University (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. Effects of Transcutaneous Vagal Nerve Stimulation on Post-Surgical Return to Consciousness, Delirium, and Depression

    NCT07610655

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Northwestern University Feinberg School of Medicine (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. A Study to Evaluate TNX-102 SL Monotherapy Versus Placebo in Participants With Major Depressive Disorder (MDD)

    NCT07621237

    • Phase 2
    • Ages 18 years and older
    • Sex: All

    Nearest site: Chicago Research Center (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  39. A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

    NCT07775300

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest site: Charter Research - Chicago (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. Brexanolone Lifting Outcomes Of Moms

    NCT07822321

    • Phase 3
    • Ages 15 to 45 years
    • Sex: Female

    Nearest site: Lipocine Investigational Site (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  41. Psychological Prehabilitation for Complex Gastrointestinal Surgery

    NCT07865052

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Northwestern Memorial Hospital (Chicago, IL)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  42. A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

    NCT07227454

    • Phase 3
    • Ages 12 to 17 years
    • Sex: All

    Nearest site: Endeavor Health Evanston Hospital (Evanston, IL)

    Distance to nearest recruiting site
    ~13 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. Experimental Evidence of the Impact of Parental Income on Child Mental Health and Neuroimmune Function

    NCT07641244

    • Interventional
    • Ages 10 to 18 years
    • Sex: All

    Nearest site: Northwestern University (Evanston, IL)

    Distance to nearest recruiting site
    ~13 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  44. A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression

    NCT07716098

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Psychiatric Medicine Associates LLC (Skokie, IL)

    Distance to nearest recruiting site
    ~13 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  45. Transition Care for FEP

    NCT07713849

    • Observational
    • Ages 18 to 40 years
    • Sex: All

    Nearest site: University of Chicago Ingalls Memorial Hospital (Harvey, IL)

    Distance to nearest recruiting site
    ~17 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  46. A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

    NCT04777357

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All

    Nearest site: Advanced Quality Medical Research /ID# 272902 (Orland Park, IL)

    Distance to nearest recruiting site
    ~19 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  47. A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

    NCT07105111

    • Phase 4
    • Ages 18 years and older
    • Sex: All

    Nearest site: Neurocrine Clinical Site (Naperville, IL)

    Distance to nearest recruiting site
    ~26 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Depression clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.