A Study of Esketamine Nasal Spray Versus Placebo Spray in Adult Participants With Treatment-resistant Depression
NCT07716098
This study is recruiting at 15 US sites in 10 states, according to its ClinicalTrials.gov record last updated .
Summary
The purpose of this study is to evaluate how well each individual dose of esketamine (56 milligrams [mg] and 84 mg) works when compared with placebo in improving depressive symptoms in participants with treatment resistant depression (individuals with major depressive disorder [MDD] who have not responded to at least 2 different antidepressant treatments given at an adequate dose for an adequate duration in the current episode of depression).
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Depressive Disorder, Treatment-Resistant
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Janssen Research & Development, LLC
- Last updated on ClinicalTrials.gov
- November 3, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
California · 2
- Anderson Clinical Research · Redlands, CA
- Artemis Institute for Clinical Research · San Diego, CA
Connecticut · 1
- University of Connecticut Health Center · Farmington, CT
Florida · 3
- American Family Research Group · Cape Coral, FL
- Pharmax Research Clinic Inc · Miami, FL
- Charter Research Orlando · Orlando, FL
Georgia · 2
- Psych Atlanta, P.C. · Marietta, GA
- Accelerated Clinical Research Group LLC · Snellville, GA
Idaho · 1
- Midwest Research Group · Saint Maries, ID
Illinois · 1
- Psychiatric Medicine Associates LLC · Skokie, IL
Massachusetts · 1
- Adams Clinical Watertown · Watertown, MA
New York · 2
- Neurobehavioral Research Inc · Cedarhurst, NY
- The Medical Research Network, LLC · New York, NY
Ohio · 1
- Ohio State University · Columbus, OH
Washington · 1
- Northwest Clinical Research Center · Bellevue, WA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.