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Migraine Clinical Trials Recruiting in the US

71 studies for Migraine are recruiting at 847 US sites, according to ClinicalTrials.gov data processed .

Migraine is a neurological condition that causes recurring headaches, often with nausea and sensitivity to light or sound.

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Recruiting now

Top Migraine studies by number of US sites

Showing 30 studies, most US recruiting sites first.
  1. A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

    NCT07645924

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    113 US recruiting sites
  2. A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine

    NCT07674654

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    113 US recruiting sites
  3. Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

    NCT05125302

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All
    Recruiting sites
    88 US recruiting sites
  4. Randomized Study in Children and Adolescents With Migraine: Acute Treatment

    NCT04649242

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All
    Recruiting sites
    70 US recruiting sites
  5. Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

    NCT04743141

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All
    Recruiting sites
    55 US recruiting sites
  6. Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study

    NCT06972056

    • Phase 4
    • Ages 18 to 70 years
    • Sex: All
    Recruiting sites
    36 US recruiting sites
  7. A Study to Assess the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

    NCT07816367

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    36 US recruiting sites
  8. Study of EVO756 in Adults With Migraine

    NCT07616128

    • Phase 2
    • Ages 18 to 64 years
    • Sex: All
    Recruiting sites
    33 US recruiting sites
  9. A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

    NCT06641466

    • Phase 3
    • Ages 18 to 45 years
    • Sex: Female
    Recruiting sites
    32 US recruiting sites
  10. Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects

    NCT05156398

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All
    Recruiting sites
    29 US recruiting sites
  11. A Study of Oral Atogepant Tablets to Assess Adverse Events and Change in Disease Activity To Prevent Migraine in Participants Aged 12 to 17 Years

    NCT06810505

    • Phase 3
    • Ages 12 to 17 years
    • Sex: All
    Recruiting sites
    29 US recruiting sites
  12. A Study to Assess the Adverse Events and Change in Disease Activity of Oral Atogepant Tablets in Pediatric Participants (6-17 Years of Age) With Episodic Migraine

    NCT05711394

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All
    Recruiting sites
    26 US recruiting sites
  13. Study Evaluating the Efficacy, Safety, and Tolerability of ASY202 (Dihydroergotamine Mesylate [DHE] Inhalation Powder Delivered Via a Multidose Dry Powder Inhaler) for the Acute Treatment of Migraine in Adult Patients

    NCT07646613

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    20 US recruiting sites
  14. A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

    NCT07609914

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    17 US recruiting sites
  15. A Study to Learn About the Study Medicine Called Rimegepant in Adults When Used for the Prevention of Chronic Migraine

    NCT07729462

    • Phase 3
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    16 US recruiting sites
  16. Responding With Evidence and Access for Childhood Headaches

    NCT05889624

    • Interventional
    • Ages 10 to 17 years
    • Sex: All
    Recruiting sites
    15 US recruiting sites
  17. A Study With Eptinezumab in Children and Adolescents (6 to 17 Years) With Chronic or Episodic Migraine

    NCT05164172

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All
    Recruiting sites
    14 US recruiting sites
  18. A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine

    NCT06995729

    • Phase 1
    • Ages 6 to 11 years
    • Sex: All
    Recruiting sites
    11 US recruiting sites
  19. A Study With Eptinezumab in Adolescents (12-17 Years) With Chronic Migraine

    NCT04965675

    • Phase 3
    • Ages 12 to 17 years
    • Sex: All
    Recruiting sites
    9 US recruiting sites
  20. A Study of Eptinezumab in Pediatric Participants With Episodic Migraine

    NCT05897320

    • Phase 3
    • Ages 6 to 17 years
    • Sex: All
    Recruiting sites
    9 US recruiting sites
  21. A Study to Investigate the Safety and Efficacy of MEDI0618 Compared to Placebo in Adult Participants With Episodic Migraine

    NCT06602479

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All
    Recruiting sites
    8 US recruiting sites
  22. MMA Embolization for Refractory Chronic Migraine

    NCT06735833

    • Interventional
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    8 US recruiting sites
  23. Qudexy XR for the Prevention of Migraine in Children 6 to 11 Years Old

    NCT04748601

    • Phase 4
    • Ages 6 to 11 years
    • Sex: All
    Recruiting sites
    6 US recruiting sites
  24. Pivotal Study of N-acetyl-L-leucine for CACNA1A

    NCT07221292

    • Phase 3
    • Ages 4 years and older
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  25. Study to Assess the Real-World Effectiveness of Ubrogepant in Adult Participants When Treating During the Prodrome Phase of Migraine Attacks

    NCT07310290

    • Observational
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  26. A Pivotal Clinical Study to Evaluate the MySalvia System for the Treatment of Resistant Migraine

    NCT07719608

    • Interventional
    • Ages 22 to 84 years
    • Sex: All
    Recruiting sites
    3 US recruiting sites
  27. Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics

    NCT03231241

    • Observational
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  28. Objectively Diagnose and Monitor Treatment of Light Sensitivity

    NCT03694626

    • Interventional
    • Ages 18 to 80 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  29. Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research

    NCT04806620

    • Observational
    • Ages 2 years and older
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  30. Clinical Trial of Endoscopically Guided Injection of Exparel (Bupivacaine) for the Treatment of Craniofacial Pain

    NCT04930887

    • Phase 2
    • Ages 18 to 80 years
    • Sex: All
    Recruiting sites
    1 US recruiting site

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Migraine clinical trials by city

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Migraine clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.