Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
NCT06972056
This study is recruiting at 36 US sites in 22 states, according to its ClinicalTrials.gov record last updated .
Summary
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: Be randomly assigned to one of the three medications. Provide information about their migraine pattern using a daily headache diary and during research visits.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Migraine
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 4
- Ages
- 18 to 70 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Mayo Clinic
- Last updated on ClinicalTrials.gov
- September 16, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Northern Arizona Healthcare · Flagstaff, AZ
- Mayo Clinic Arizona · Phoenix, AZ
California · 4
- Clinical Research Institute · Los Angeles, CA
- Keck School of Medicine of USC · Los Angeles, CA
- Desert Physicians Medical Group · Palm Springs, CA
- The Neurology Group · Pomona, CA
Colorado · 1
- University of Colorado Anschutz Medical Campus · Aurora, CO
Florida · 4
- Memorial Healthcare · Hollywood, FL
- Mayo Clinic Florida · Jacksonville, FL
- Apple Med Research · Miami, FL
- University of Miami · Miami, FL
Kansas · 1
- Neuroscience Research Center · Overland Park, KS
Massachusetts · 1
- Clinical Trials of New England · Hyde Park, MA
Minnesota · 1
- Mayo Clinic · Rochester, MN
Missouri · 1
- Washington University St Louis · St Louis, MO
Nebraska · 1
- Nebraska Medical Center · Omaha, NE
Nevada · 1
- Advanced Research Institute Reno · Reno, NV
New Jersey · 1
- JFK Neuroscience Institute · Edison, NJ
New York · 3
- Nuvance Health Institute · Kingston, NY
- Northwell Health · Manhasset, NY
- Mt Sinai Icahn School of Medicine · New York, NY
North Carolina · 5
- Onsite Clinical Solutions Ballantyne · Charlotte, NC
- Onsite Clinical Solutions Mecklenburg · Charlotte, NC
- Onsite Clinical Solutions Park Cedar Dr. · Charlotte, NC
- Onsite Clinical Solutions Salisbury · Salisbury, NC
- Wake Forest University Health · Winston-Salem, NC
Ohio · 1
- Ohio State University Wexner Medical Center · Columbus, OH
Oregon · 1
- Advanced Research Institute · Portland, OR
Pennsylvania · 1
- University of Pennsylvania · Philadelphia, PA
Rhode Island · 1
- Brown University Health · Providence, RI
Tennessee · 1
- Vanderbilt Medical Center · Nashville, TN
Texas · 1
- DHR Health Headache Center · McAllen, TX
Utah · 1
- Advanced Research Institute Ogden · Ogden, UT
West Virginia · 1
- West Virginia University · Morgantown, WV
Wisconsin · 2
- Marshfield Clinic Research Institute · Marshfield, WI
- The Medical College of Wisconsin · Milwaukee, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.