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Depression Clinical Trials near Boston, MA

98 studies for Depression are recruiting at 126 sites within 50 miles of Boston, Massachusetts, according to ClinicalTrials.gov data processed .

Distances are city-level approximations. See all Depression trials in the US or all trials near Boston.

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Depression studies enrolling near Boston

Showing the 50 nearest of 98 studies.
  1. E-Mindfulness Approaches for Living After Breast Cancer

    NCT06748222

    • Phase 3
    • Ages 18 to 50 years
    • Sex: All

    Nearest sites: Tufts Medical Center (Boston, MA); Tufts Medical Center Cancer Center Stoneham (Stoneham, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    8 sites within 50 mi
  2. A Study of Brenipatide in Adult Participants With Major Depressive Disorder

    NCT07412756

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Adams Clinical Boston (Boston, MA); Adams Clinical Watertown (Watertown, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    3 sites within 50 mi
  3. Brain Connectivity in Depression

    NCT03276793

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Brigham and Women's Hospital (Boston, MA); Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  4. A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression

    NCT03887715

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Massachusetts General Hospital (Boston, MA); Healthy Perspective (Nashua, NH)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  5. Buspirone and Melatonin for Depression Following Traumatic Brain Injury

    NCT04400266

    • Phase 4
    • Ages 18 to 64 years
    • Sex: All

    Nearest sites: Massachusetts General Hospital (Boston, MA); Massachusetts General Hospital Home Base Program (Charlestown, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  6. Modulating Exercise Dosage to Improve Concussion Recovery

    NCT05434130

    • Phase 1/2
    • Ages 13 to 18 years
    • Sex: All

    Nearest sites: Boston Children's Hospital (Boston, MA); Spaulding Rehabilitation Hospital (Cambridge, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  7. Triage Survey for Psychiatry Research Eligibility

    NCT05800925

    • Observational
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Adams Clinical, Boston (Boston, MA); Adams Clinical, Watertown (Watertown, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  8. Neural Mechanisms of Family-Focused Treatment for Youth Depression

    NCT06289010

    • Interventional
    • Ages 7 to 12 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest sites: Boston University (Boston, MA); Athinoula A. Martinos Imaging Center at Massachusetts Institute of Technology (Charlestown, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  9. Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND)

    NCT06423430

    • Interventional
    • Ages 22 to 70 years
    • Sex: All

    Nearest sites: Beth Israel Deaconess Medical Center (Boston, MA); Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  10. Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

    NCT06740383

    • Observational
    • Ages 18 to 40 years
    • Sex: All

    Nearest sites: Beth Israel Deaconess Medical Center (Boston, MA); McLean Hospital (Belmont, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  11. Long-Term Study to Assess the Safety and Tolerability of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06966401

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Neurocrine Clinical Site (Boston, MA); Neurocrine Clinical Site (Watertown, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  12. RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

    NCT07002034

    • Phase 2
    • Ages 18 to 80 years
    • Sex: All

    Nearest sites: Dana Farber Cancer Institute (Boston, MA); University of Massachusetts Chan Medical Center (Worcester, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  13. A Study to Evaluate the Efficacy and Safety of Esketamine for Reduction of Symptoms of Major Depressive Disorder

    NCT07227454

    • Phase 3
    • Ages 12 to 17 years
    • Sex: All

    Nearest sites: Boston Childrens Hospital (Boston, MA); Bradley Hospital (East Providence, RI)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  14. Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant Depression

    NCT07563868

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest sites: Massachusetts General Hospital (Boston, MA); Massachusetts General Hospital's Depression and Clinical Research program (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  15. A Study of Seltorexant as Monotherapy in Adults and Elderly Participants With Major Depressive Disorder

    NCT07573176

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest sites: Adams Clinical Boston (Boston, MA); Adams Clinical Watertown (Watertown, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  16. A Phase 3 Trial of DT120 for Major Depressive Disorder (Ascend)

    NCT07592689

    • Phase 3
    • Ages 18 to 74 years
    • Sex: All

    Nearest sites: Adams Clinical Watertown (Boston, MA); Vitalix Clinical (Worcester, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  17. A Study of Brenipatide (LY3537031) in Adult Participants With Major Depressive Disorder

    NCT07775300

    • Phase 3
    • Ages 18 to 75 years
    • Sex: All

    Nearest sites: Adams Clinical Boston (Boston, MA); Adams Clinical Watertown (Watertown, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    2 sites within 50 mi
  18. Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

    NCT04296604

    • Interventional
    • Ages 18 to 65 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  19. Effects of Intranasal Oxytocin in Patients With Arginine-vasopressin Deficiency

    NCT04789148

    • Phase 1
    • Ages 18 years and older
    • Sex: All

    Nearest site: Massachusetts General Hospital, Neuroendocrine Unit (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  20. Peripheral Neuroimmune Mechanisms of Hyperthermia

    NCT05366270

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Massachusetts General Hospital Depression Clinical & Research Program (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  21. Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression

    NCT05450432

    • Phase 4
    • Ages 18 to 70 years
    • Sex: All

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  22. Targeting Specific Brain Networks to Treat Specific Symptoms in Depression

    NCT05523817

    • Interventional
    • Ages 18 to 65 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  23. Using Machine Learning to Optimize User Engagement and Clinical Response to Digital Mental Health Interventions

    NCT05567640

    • Interventional
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Center for Anxiety and Related Disorders (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  24. Neuroactive Steroid to Treat Depressed Mood: A Trial for People With HIV

    NCT05570812

    • Phase 2
    • Ages 18 to 85 years
    • Sex: All

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  25. Transcranial Near Infrared Radiation and Cerebral Blood Flow in Depression - R33

    NCT05573074

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Harvard Medical School (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  26. Mindfulness-Based fMRI Neurofeedback for Depression

    NCT05617495

    • Interventional
    • Ages 13 to 18 years
    • Sex: All

    Nearest site: Northeastern University (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  27. Training in Evidence-based Treatments in Psycho-Oncology

    NCT05674357

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Massachusetts General Hospital Cancer Center (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  28. Telemedicine-Delivered Unified Protocol for Cognitive Behavioral Therapy for Anxiety and Depression

    NCT05734313

    • Interventional
    • Ages 18 to 64 years
    • Sex: All

    Nearest site: Boston University (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  29. Expressive Writing on Minority Stressors Among Sexual Minority Veterans

    NCT05897021

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  30. Preventing Depression of Chinese American Adolescents by RRE

    NCT05921201

    • Interventional
    • Ages 14 to 18 years
    • Sex: All
    • Accepts healthy volunteers

    Nearest site: Northeastern University (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  31. Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

    NCT05962879

    • Interventional
    • Ages 14 to 19 years
    • Sex: All

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  32. Integrative Mindfulness-Based Predictive Approach for Chronic Low Back Pain Treatment

    NCT06106191

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Boston Medical Center (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  33. Cognitive Dysfunction and Inflammation in Depression: Experimental Inhibition Via Infliximab

    NCT06136546

    • Phase 2
    • Ages 25 to 50 years
    • Sex: All

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  34. A Study to Evaluate the Efficacy of AXS-05 Compared to Bupropion in Preventing the Relapse of Depressive Symptoms

    NCT06223880

    • Phase 4
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Clinical Research Site (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  35. Study on Allopregnanolone and Depression in Women Across the Menopause Transition

    NCT06238700

    • Interventional
    • Ages 40 to 60 years
    • Sex: Female

    Nearest site: Beth Israel Deaconess Medical Center (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  36. Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions

    NCT06557005

    • Interventional
    • Ages 18 years and older
    • Sex: Female

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  37. Cannabis, Linked Emotions, and Adolescent Risk Study

    NCT06576076

    • Interventional
    • Ages 12 to 18 years
    • Sex: All

    Nearest site: Massachusetts General Hopsital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  38. Study of ABX-002 for the Adjunctive Treatment of Major Depressive Disorder (AMPLIFY)

    NCT06633016

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Autobahn Site #137 (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  39. Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke

    NCT06654414

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Fenway Health (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  40. Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)

    NCT06786624

    • Phase 3
    • Ages 18 years and older
    • Sex: All

    Nearest site: Neurocrine Clinical Site (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  41. A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder

    NCT06793397

    • Phase 3
    • Ages 18 to 85 years
    • Sex: All

    Nearest site: Adams Clinical Boston (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  42. Therapy Dog Visits for Patients Hospitalized With Traumatic Injuries

    NCT06812247

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Boston Medical Center, Trauma Inpatient Service (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  43. Evaluation of Efficacy and Safety of Milsaperidone as Adjunctive Therapy in Patients With Major Depressive Disorder

    NCT06830044

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Vanda Investigational Site (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  44. Preliminary Efficacy Trial of a Digital Intervention for Depression and Cannabis Use

    NCT06878859

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  45. RISE Versus Advocacy-based Enhanced Care as Usual for Patients Experiencing IPV

    NCT06906302

    • Interventional
    • Ages 18 years and older
    • Sex: All

    Nearest site: VA Boston Healthcare System (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  46. Accelerated TMS for Perinatal Depression

    NCT06968390

    • Interventional
    • Ages 18 to 55 years
    • Sex: Female

    Nearest site: Brigham and Women's Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  47. Home-Based tDCS Treatment Of Major Depressive Disorder

    NCT06976697

    • Interventional
    • Ages 22 to 70 years
    • Sex: All

    Nearest site: Curavit Clinical Research (virtual study site) (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  48. TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

    NCT07048574

    • Observational
    • Ages 18 months to 11 years
    • Sex: All

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  49. A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

    NCT07065240

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Seaport Investigator Site (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi
  50. Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression

    NCT07082998

    • Interventional
    • Ages 18 to 65 years
    • Sex: All

    Nearest site: Massachusetts General Hospital (Boston, MA)

    Distance to nearest recruiting site
    <1 mi (city-level)
    Recruiting sites
    1 site within 50 mi

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Depression clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.