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Bipolar Disorder Clinical Trials Recruiting in the US

78 studies for Bipolar Disorder are recruiting at 469 US sites, according to ClinicalTrials.gov data processed .

Bipolar disorder is a mental health condition that causes shifts in mood, energy and activity levels, including episodes of mania and depression.

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Recruiting now

Top Bipolar Disorder studies by number of US sites

Showing 30 studies, most US recruiting sites first.
  1. Safety and Tolerability Trial of Lumateperone in Pediatric Patients With Schizophrenia, Bipolar Disorder or Autism Spectrum Disorder

    NCT06229210

    • Phase 3
    • Ages 5 to 17 years
    • Sex: All
    Recruiting sites
    47 US recruiting sites
  2. A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

    NCT06929273

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    40 US recruiting sites
  3. ALTO-100 in Bipolar Disorder With Depression (BD-D)

    NCT06656416

    • Phase 2
    • Ages 18 to 70 years
    • Sex: All
    Recruiting sites
    39 US recruiting sites
  4. Multicenter Study of Lumateperone for the Treatment of Bipolar Depression in Pediatric Patients

    NCT06372964

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All
    Recruiting sites
    34 US recruiting sites
  5. A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With Bipolar I or II Disorder

    NCT06696755

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    33 US recruiting sites
  6. A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

    NCT04777357

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All
    Recruiting sites
    31 US recruiting sites
  7. Multicenter Study to Assess the Efficacy and Safety of LB-102 in the Treatment of Adult Patients With BP1MDE.

    NCT07494305

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    26 US recruiting sites
  8. A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-2)

    NCT06951711

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    21 US recruiting sites
  9. A Study to Evaluate the Efficacy and Safety of Adjunctive KarXT for the Treatment of Mania, With or Without Mixed Features, in Participants With Bipolar-I Disorder Taking Lithium, Valproate, or Lamotrigine

    NCT07140913

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    20 US recruiting sites
  10. A Study of Brenipatide in Adult Participants With Bipolar Disorder (RENEW-Bipolar-1)

    NCT07286175

    • Phase 2
    • Ages 18 to 75 years
    • Sex: All
    Recruiting sites
    20 US recruiting sites
  11. A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor

    NCT07105111

    • Phase 4
    • Ages 18 years and older
    • Sex: All
    Recruiting sites
    19 US recruiting sites
  12. A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

    NCT06951698

    • Phase 3
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    18 US recruiting sites
  13. Study to Evaluate Weight Gain as Assessed by Change in BMI Z-score in Pediatric Subjects With Schizophrenia or Bipolar I Disorder

    NCT05303064

    • Phase 3
    • Ages 10 to 17 years
    • Sex: All
    Recruiting sites
    15 US recruiting sites
  14. Safety and Tolerability of Open-Labeled Iloperidone in Adolescents

    NCT05648591

    • Phase 4
    • Ages 12 to 17 years
    • Sex: All
    Recruiting sites
    11 US recruiting sites
  15. An Assessment of Efficacy, Safety, and Pharmacokinetics of NBI-1117568 in Adults With Bipolar I Disorder With Current Mania

    NCT07288320

    • Phase 2
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    11 US recruiting sites
  16. Biomarkers/Biotypes, Course of Early Psychosis and Specialty Services

    NCT06740383

    • Observational
    • Ages 18 to 40 years
    • Sex: All
    Recruiting sites
    6 US recruiting sites
  17. CLOZAPINE Response in Biotype-1

    NCT04580134

    • Phase 4
    • Ages 18 to 60 years
    • Sex: All
    Recruiting sites
    5 US recruiting sites
  18. Enhanced Coordinated Specialty Care for Early Psychosis

    NCT06071858

    • Interventional
    • Ages Any age
    • Sex: All
    Recruiting sites
    5 US recruiting sites
  19. Determining Efficacy and Safety of BXCL501 in Agitation Associated With Pediatric Schizophrenia and Bipolar Disorder

    NCT05025605

    • Phase 1
    • Ages 10 to 17 years
    • Sex: All
    Recruiting sites
    4 US recruiting sites
  20. Cerebellar Modulation of Cognition in Psychosis

    NCT06107764

    • Interventional
    • Ages 18 to 55 years
    • Sex: All
    Recruiting sites
    2 US recruiting sites
  21. Intermittent Theta Burst Stimulation (iTBS) for Emotion Regulation in Bipolar Disorder

    NCT06274567

    • Interventional
    • Ages 24 to 65 years
    • Sex: All
    Recruiting sites
    2 US recruiting sites
  22. Use of Ketosis in Modulating Metabolic Pathways in Bipolar Disorder

    NCT06373016

    • Interventional
    • Ages 18 to 45 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    2 US recruiting sites
  23. Child Bipolar Network Ketogenic Diet Approach to Bipolar Disorder in Adolescents

    NCT06920940

    • Interventional
    • Ages 12 to 21 years
    • Sex: All
    Recruiting sites
    2 US recruiting sites
  24. State Representation in Early Psychosis 2

    NCT07834203

    • Observational
    • Ages 15 to 45 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    2 US recruiting sites
  25. Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

    NCT00024635

    • Observational
    • Ages 3 to 99 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  26. Cerebellar Stimulation and Cognitive Control

    NCT03217110

    • Interventional
    • Ages 18 to 90 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  27. Adjunctive Allogeneic Mesenchymal Stem Cells for Treatment-resistant Bipolar Depression

    NCT03522545

    • Phase 1
    • Ages 18 to 65 years
    • Sex: All
    Recruiting sites
    1 US recruiting site
  28. Attentional Biases, Reward Sensitivity, and Cognitive Control in Adults With Bipolar Disorder

    NCT03829787

    • Observational
    • Ages 18 years and older
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site
  29. Magnetic Seizure Therapy in Bipolar Depression (MST-BpD) and Treatment Resistant Depression (MST-TRD)

    NCT04080778

    • Interventional
    • Ages 22 to 85 years
    • Sex: All
    Recruiting sites
    1 US recruiting site
  30. Transcranial Direct Current Stimulation (tDCS) Neuromodulation of Executive Function Across Neuropsychiatric Populations

    NCT04296604

    • Interventional
    • Ages 18 to 65 years
    • Sex: All
    • Accepts healthy volunteers
    Recruiting sites
    1 US recruiting site

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Bipolar Disorder clinical trials by city

FAQ

Common questions

What is a clinical trial?
A clinical trial is a research study in people that tests a medical, surgical or behavioral intervention, such as an investigational drug or device. Observational studies are also listed: they collect information without assigning a treatment. Read how clinical trials work.
Is there compensation for joining a Bipolar Disorder clinical trial?
Compensation for time and travel may be available, but it varies by study and some studies offer none. The amount and schedule are reviewed by an ethics board and described in the consent form. See compensation in clinical trials.
How do I check if I'm eligible?
Each study lists age, sex and other inclusion and exclusion criteria on its ClinicalTrials.gov record. Only the study team can confirm eligibility, usually through a screening call or visit. Talk with your own doctor before joining any study.

Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.