Developing New Ways to Detect Respiratory Impairment Early in ALS

Summary

The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. The study will examine whether changes in breathing, magnetic resonance imaging (MRI) of the brainstem and spinal cord, and blood markers can identify early signs of ALS before major physical changes occur. The main questions the study aims to answer are: Can changes in automatic breathing help identify early ALS-related changes? Can breathing measures distinguish people with ALS from people without ALS?

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Amyotrophic Lateral Sclerosis (ALS)

Eligibility basics and study details

Study type

Observational

Phase

Not applicable

Ages

18 years and older

Sex

All

Healthy volunteers

Accepted

Sponsor

Thomas Jefferson University

Last updated on ClinicalTrials.gov

September 28, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites