Urine Sodium-Driven Diuretic Adjustment Strategy in Acute Decompensated Heart Failure

Summary

The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? Does targeting a higher urine sodium goal reduce hospital length of stay?

Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov

Conditions studied

• Heart Failure
• Heart Failure - NYHA II - IV
• Heart Failure Acute
• Acute Heart Failure (AHF)

Eligibility basics and study details

Study type

Interventional

Phase

Phase 4

Ages

18 years and older

Sex

All

Healthy volunteers

Not accepted

Sponsor

Lakeland Regional Health Systems, Inc.

Last updated on ClinicalTrials.gov

April 9, 2026

These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.

US recruiting sites