A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
NCT07137598
This study is recruiting at 18 US sites in 13 states, according to its ClinicalTrials.gov record last updated .
Summary
This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe rheumatoid arthritis (RA) who have an inadequate response or intolerance to TNF and/or JAK inhibitors.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Rheumatoid Arthritis
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 2
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Hoffmann-La Roche
- Last updated on ClinicalTrials.gov
- October 16, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 2
- Arizona Arthritis & Rheumatology Associates, P.C. · Avondale, AZ
- SunValley Arthritis Center Ltd. · Peoria, AZ
California · 3
- University of California Medical Center · La Jolla, CA
- Cedars Sinai Medical Center · Los Angeles, CA
- Inland Rheumatology Clinical Trials Incorporated · Upland, CA
Florida · 1
- West Broward Rheumatology Associates, Inc. · Tamarac, FL
Illinois · 1
- Willow Rheumatology and Wellness PLLC · Willowbrook, IL
Kentucky · 1
- Equity Medical · Owensboro, KY
Louisiana · 1
- Accurate Clinical Research Inc. · Lake Charles, LA
Michigan · 1
- Henry Ford Medical Center- New Center One · Detroit, MI
New York · 1
- Equity Medical · The Bronx, NY
Ohio · 1
- Ohio State University Wexner Medical Center · Columbus, OH
Pennsylvania · 1
- Altoona Center For Clinical Research · Duncansville, PA
Texas · 3
- Precision Comprehensive Clinical Research Solutions · Colleyville, TX
- Accurate Clinical Management · Houston, TX
- DM Clinical Research at Tomball · Tomball, TX
Virginia · 1
- Tidewater Clinical Research · Chesapeake, VA
Wisconsin · 1
- Rheumatic Disease Center · Glendale, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.