EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
NCT07064473
This study is recruiting at 201 US sites in 39 states, according to its ClinicalTrials.gov record last updated .
Summary
This study is open to adults with type 2 diabetes, high blood pressure, and cardiovascular disease. People can join the study if they have these conditions and do not have a history of heart failure. The purpose of this study is to find out if a medicine called vicadrostat, when taken with empagliflozin, helps reduce cardiovascular risk in people with these conditions. The study will compare this combination to a placebo version of vicadrostat with empagliflozin. Participants are put into 2 groups randomly, which means by chance.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Diabetes Mellitus, Type 2
- Hypertension
- Cardiovascular Diseases
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Boehringer Ingelheim
- Last updated on ClinicalTrials.gov
- October 14, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 3
- Pinnacle Research Group, LLC · Anniston, AL
- Eastern Shore Research Group · Fairhope, AL
- Lakeview Clinical Research · Guntersville, AL
Arizona · 6
- Arizona Clinical Trials - Chandler · Chandler, AZ
- Elite Clinical Studies · Phoenix, AZ
- Clinical Research Institute of Arizona, LLC · Sun City West, AZ
- Fiel Family & Sports Medicine · Tempe, AZ
- Arizona Clinical Trials · Tucson, AZ
- Yuma Clinical Trials · Yuma, AZ
California · 14
- National Heart Institute · Beverly Hills, CA
- Hope Clinical Research · Canoga Park, CA
- John Muir Physician Network Clinical Research Center · Concord, CA
- Velocity Clinical Research-Huntington Park · Huntington Park, CA
- Velocity Clinical Research, San Diego · La Mesa, CA
- First Valley Medical Group · Lancaster, CA
- ARK Clinical Research · Long Beach, CA
- Diabetes Associates Medical Group · Orange, CA
- Empire Clinical Research · Pomona, CA
- Velocity Clinical Research - San Bernardino · San Bernardino, CA
- Acclaim Clinical Research · San Diego, CA
- NorthBay Clinical Research, LLC · Santa Rosa, CA
- The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center · Torrance, CA
- Blue Coast Research Center, LLC · Vista, CA
Colorado · 1
- Rocky Mountain Regional VA Medical Center · Aurora, CO
Connecticut · 3
- Cardiology Physicians of Fairfield County - Bridgeport · Bridgeport, CT
- CMR of Greater New Haven, LLC · Hamden, CT
- Cardiology Associates of Fairfield County · Stamford, CT
Florida · 35
- Excel Medical Clinical Trials · Boca Raton, FL
- Clinical Research of West Florida, Inc. · Clearwater, FL
- Beautiful Minds Clinical Research Center · Cutler Bay, FL
- Hillcrest Medical Research · DeLand, FL
- University Clinical Research Deland, LLC · DeLand, FL
- Universal Axon Clinical Research · Doral, FL
- Northeast Research Institute · Fleming Island, FL
- Covenant Metabolic Specialists, LLC - Fort Myers · Fort Myers, FL
- Velocity Clinical Research-Hallandale Beach-67888 · Hallandale, FL
- East Coast Institute for Research, LLC - Southside · Jacksonville, FL
- Jacksonville Center for Clinical Research · Jacksonville, FL
- Northeast Research Institute · Jacksonville, FL
- Westside Center for Clinical Research · Jacksonville, FL
- East Coast Institute for Research - Lake City · Lake City, FL
- Clinical Research of Central Florida - Lakeland · Lakeland, FL
- Alma Clinical Research, Inc. · Miami, FL
- Finlay Medical Research Corp · Miami, FL
- IMIC Inc. · Miami, FL
- Oceane7 Clinical Research · Miami, FL
- Optimus U Corporation-Miami-69452 · Miami, FL
- Research Institute of South Florida, Inc. · Miami, FL
- Indago Research and Health Center · Miami Lakes, FL
- Advanced Research for Health Improvement, LLC · Naples, FL
- Suncoast Clinical Research · New Port Richey, FL
- Florida Institute for Clinical Research · Orlando, FL
- Ormond Beach Clinical Research · Ormond Beach, FL
- Cardiology Partners Clinical Research Institute · Palm Beach Gardens, FL
- Innovation Medical Research Center · Palmetto Bay, FL
- Center for Diabetes, Obesity and Metabolism · Pembroke Pines, FL
- Peace River Cardiovascular Center · Port Charlotte, FL
- Covenant Metabolic Specialists, LLC - Brandon · Riverview, FL
- East Coast Institute for Research, LLC-Saint Augustine-63032 · Saint Augustine, FL
- IMA Clinical Research St. Petersburg · St. Petersburg, FL
- Covenant Metabolic Specialists, LLC - Sarasota · University Park, FL
- Cardiology Partners Clinical Research Institute · Wellington, FL
Georgia · 7
- Centricity Research, Endocrine Consultants · Columbus, GA
- NSC Research Inc · Johns Creek, GA
- The Jones Center Clinical Research, LLC · Macon, GA
- Urban Family Practice Associates, PC · Marietta, GA
- Javara-Savannah-67450 · Savannah, GA
- Javara Research - Thomasville · Thomasville, GA
- Atlanta Heart Specialists, LLC · Tucker, GA
Hawaii · 1
- Pacific Diabetes & Endocrine Center · Honolulu, HI
Idaho · 1
- Rocky Mountain Clinical Research - Idaho Falls · Idaho Falls, ID
Illinois · 3
- Cedar Crosse Research Center · Chicago, IL
- Accellacare of Duly - Lombard · Lombard, IL
- Accellacare of Duly · Oak Lawn, IL
Indiana · 5
- American Health Network - Avon · Avon, IN
- Midwest Cardiovascular Research and Education Foundation · Elkhart, IN
- American Health Network - Greenfield · Greenfield, IN
- American Health Network - Muncie · Muncie, IN
- Reid Physician Associates · Richmond, IN
Kansas · 3
- AMR El Dorado · El Dorado, KS
- Cotton O'Neil Diabetes & Endocrinology Center · Topeka, KS
- Tekton Research - Wichita · Wichita, KS
Kentucky · 3
- Qualmedica Research - Bowling Green · Bowling Green, KY
- The Research Group of Lexington · Lexington, KY
- Research Integrity, LLC · Owensboro, KY
Louisiana · 7
- Grace Research, LLC-Bossier City-51040 · Bossier City, LA
- Louisiana Heart Center - Covington · Covington, LA
- IMA Clinical Research Monroe · Monroe, LA
- Grace Research, LLC-Shreveport-64616 · Shreveport, LA
- Louisiana Heart Center - Slidell · Slidell, LA
- Monroe Research, LLC · West Monroe, LA
- Southern Clinical Research - Zachary · Zachary, LA
Maryland · 4
- Ascension Saint Agnes Heart Care · Baltimore, MD
- Medstar Montgomery Medical Center · Olney, MD
- MD Medical Research · Oxon Hill, MD
- TidalHealth, Inc. · Salisbury, MD
Massachusetts · 1
- ActivMed Practices & Research · Methuen, MA
Michigan · 4
- Revival Research Institute, LLC - Dearborn · Dearborn, MI
- Aa Mrc Llc · Flint, MI
- Elite Research Center, LLC · Flint, MI
- Oakland Medical Center · Troy, MI
Mississippi · 1
- Prime Health and Wellness · Fayette, MS
Missouri · 4
- Jefferson City Medical Group · Jefferson City, MO
- Johnson County ClinTrials · Kansas City, MO
- St. Louis Heart and Vascular, P.C. · St Louis, MO
- Sundance Clinical Research, LLC · St Louis, MO
Montana · 1
- Billings Clinic - Billings · Billings, MT
Nebraska · 2
- Methodist Physicians Clinic · Fremont, NE
- Quality Clinical Research - Omaha · Omaha, NE
Nevada · 5
- AB Clinical Trials · Las Vegas, NV
- Las Vegas Clinical Trials · Las Vegas, NV
- Palm Research Center · Las Vegas, NV
- Palm Research Center · Las Vegas, NV
- Vector Clinical Trials - Las Vegas · Las Vegas, NV
New Jersey · 3
- Advanced Heart Care, LLC · Bridgewater, NJ
- NJ Heart LLC · Linden, NJ
- Cardio Metabolic Institute · Somerset, NJ
New Mexico · 2
- IMA Clinical Research Albuquerque · Albuquerque, NM
- New Mexico Clinical Research and Osteoporosis Center, Inc. · Albuquerque, NM
New York · 10
- Albany Med Health System - Washington Avenue Extension · Albany, NY
- Velocity Clinical Research - Binghamton · Binghamton, NY
- RCR - Buffalo · Buffalo, NY
- New York Cardiovascular Specialist PC · New York, NY
- NYC Research Inc. · New York, NY
- Northwell Health - Peconic Bay Medical Group at Riverhead · Riverhead, NY
- Rochester Clinical Research, Inc · Rochester, NY
- Saratoga Clinical Research, LLC · Saratoga Springs, NY
- Southgate Medical Group/ Southgate Medical Park · West Seneca, NY
- Great Lakes Medical Research · Westfield, NY
North Carolina · 8
- Cary Cardiology · Cary, NC
- The University of North Carolina at Chapel Hill · Chapel Hill, NC
- Physicians East, PA · Greenville, NC
- IMA Clinical Research Lenoir · Lenoir, NC
- Accellacare-Mooresville-69123 · Mooresville, NC
- Lucas Research, Inc. · Morehead City, NC
- Accellacare-Wilmington-67123 · Wilmington, NC
- Wake Forest University Health Sciences-Winston-Salem-61707 · Winston-Salem, NC
North Dakota · 1
- Lillestol Research, LLC · Fargo, ND
Ohio · 5
- The Christ Hospital · Cincinnati, OH
- Velocity Clinical Research-Cincinnati-69044 · Cincinnati, OH
- Centricity Research-Columbus-68879 · Columbus, OH
- Remington-Davis Clinical Research, Inc · Columbus, OH
- Clinical Research Institute of Ohio, LLC · Westlake, OH
Oklahoma · 2
- South Oklahoma Heart Research Group · Oklahoma City, OK
- Tekton Research Oklahoma City · Oklahoma City, OK
Pennsylvania · 5
- Heritage Valley Medical Group · Beaver, PA
- Capital Area Research, LLC · Camp Hill, PA
- Thomas Jefferson University · Philadelphia, PA
- Tristar Clinical Investigations PC · Philadelphia, PA
- Preferred Primary Care Physicians-Pittsburgh-63932 · Pittsburgh, PA
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.