Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
NCT07037433
This study is recruiting at 137 US sites in 34 states, according to its ClinicalTrials.gov record last updated .
Summary
The primary objective of this trial is to demonstrate that maridebart cafraglutide is superior to placebo when given as an adjunct to standard of care with respect to reducing cardiovascular (CV) morbidity and mortality.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Atherosclerotic Cardiovascular Disease
- Overweight
- Obesity
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 45 to 99 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- Amgen
- Last updated on ClinicalTrials.gov
- October 8, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 5
- Alliance For Multispecialty Research - Daphne · Daphne, AL
- Eastern Shore Research Institute · Fairhope, AL
- Heart Center Research LLC · Huntsville, AL
- Mobile Heart Specialists PC · Mobile, AL
- Syed Research Consultants LLC · Sheffield, AL
Arizona · 2
- Medical Advancement Centers of Arizona · Phoenix, AZ
- Synexus Clinical Research US, Inc. · Phoenix, AZ
California · 8
- Valley Clinical Trials, LLC dba Flourish Research · Covina, CA
- Velocity Clinical Research- Huntington Park · Huntington Park, CA
- Orange County Research Center · Lake Forest, CA
- Biopharma Informatic - The Cardiovascular Center · Redding, CA
- Acclaim Clinical Research · San Diego, CA
- Encompass Clinical Research · Spring Valley, CA
- Diablo Clinical Research · Walnut Creek, CA
- Focus Clinical Research · West Hills, CA
Delaware · 1
- Family Practice Associates · Wilmington, DE
Florida · 23
- Excel Medical Clinical Trials · Boca Raton, FL
- Velocity Clinical Research - New Smyrna Beach · Edgewater, FL
- Alliance for Multispecialty Research - Fort Myers · Fort Myers, FL
- Elite Cardiac Research Center LLC · Hialeah, FL
- Elite Clinical Research · Hialeah, FL
- Encore Medical Research LLC · Hollywood, FL
- Zenith Clinical Research · Hollywood, FL
- East Coast Institute for Research, LLC · Jacksonville, FL
- Clinical Research of Central Florida · Lakeland, FL
- South Florida Clinical Research · Margate, FL
- Finlay Medical Research · Miami, FL
- New Horizon Research Center · Miami, FL
- Suncoast Research Group LLC · Miami, FL
- Indago Research and Health Center · Miami Lakes, FL
- Panax Clinical Research · Miami Lakes, FL
- San Marcus Research Clinic Inc · Miami Lakes, FL
- West Orange Endocrinology · Ocoee, FL
- Cardiology Partners Clinical Research Institute · Palm Beach Gardens, FL
- Peace River Cardiovascular Center · Port Charlotte, FL
- Progressive Medical Research · Port Orange, FL
- Saint Johns Center for Clinical Research · Saint Augustine, FL
- Intercoastal Medical Group · Sarasota, FL
- Winter Haven Hospital · Winter Haven, FL
Georgia · 3
- East Coast Institute for Research LLC at Canton Georgia · Canton, GA
- The Jones Center Clinical Research · Macon, GA
- Velocity Clinical Research - Savannah · Savannah, GA
Idaho · 1
- Velocity Clinical Research - Boise · Meridian, ID
Illinois · 5
- Endeavor Health-Northwest Community Healthcare · Arlington Heights, IL
- Eagle Clinical Research · Chicago, IL
- University of Chicago · Chicago, IL
- Alliance For Multispecialty Research - Oak Brook · Oak Brook, IL
- Prarie Education and Research · Springfield, IL
Indiana · 2
- Cardiovascular Research of Northwest Indiana LLC · Munster, IN
- Velocity Clinical Research - Valparaiso · Valparaiso, IN
Iowa · 2
- McFarland Clinic PC · Ames, IA
- Midwest Cardiovascular Research Foundation · Davenport, IA
Kansas · 1
- Cotton-ONeil Diabetes and Endocrinology Center · Topeka, KS
Louisiana · 2
- Cardiovascular Associates Research, LLC · Covington, LA
- Tandem Clinical Research - Marrero · Marrero, LA
Maryland · 3
- Ascension Saint Agnes Heart Care · Baltimore, MD
- MD Medical Research · Oxon Hill, MD
- Velocity Clinical Research - Rockville · Rockville, MD
Massachusetts · 2
- Brigham and Womens Hospital · Boston, MA
- Btc of New Bedford · New Bedford, MA
Minnesota · 2
- Fairview Health Services M Health Fairview St Johns Hospital · Maplewood, MN
- Minneapolis Heart Institute Foundation · Minneapolis, MN
Mississippi · 2
- Jackson Heart Clinic · Jackson, MS
- Cardiology Associates of North Mississippi · Tupelo, MS
Missouri · 4
- StudyMetrix Research · City of Saint Peters, MO
- Alliance for Multispecialty Research - Kansas City · Kansas City, MO
- Kansas City Veterans Affairs Medical Center · Kansas City, MO
- Saint Louis Heart and Vascular PC · St Louis, MO
Nebraska · 3
- Bryan Heart · Lincoln, NE
- University of Nebraska Medical Center · Omaha, NE
- Primary Clinical Research · Papillion, NE
Nevada · 2
- Excel Clinical Research · Las Vegas, NV
- Vector Clinical Trials · Las Vegas, NV
New Jersey · 1
- CardioMetabolic Collaborative Clinic · Somerset, NJ
New York · 5
- Velocity Clinical Research - Binghamton · Binghamton, NY
- Hudson Valley Cardiovascular Practice PC · Poughkeepsie, NY
- Rochester Clinical Research · Rochester, NY
- Saratoga Clinical Research, LLC · Saratoga Springs, NY
- Southgate Medical Group · West Seneca, NY
North Carolina · 10
- Novant Health Heart and Vascular Institute · Charlotte, NC
- Velocity Clinical Research - Durham · Durham, NC
- Moses H Cone Memorial Hospital · Greensboro, NC
- Monroe Biomedical Research · Monroe, NC
- West Clinical Research · Morehead City, NC
- Burke Primary Care Family Practice · Morganton, NC
- Accellacare of Raleigh · Raleigh, NC
- Accellacare of Piedmont Healthcare · Statesville, NC
- Brookview Hills Research Associates Llc · Winston-Salem, NC
- Wake Forest University Health Sciences · Winston-Salem, NC
Ohio · 5
- Velocity Clinical Research - Cleveland · Beachwood, OH
- Aultman Hospital, Cardiovascular Consultants, Inc · Canton, OH
- Velocity Clinical Research - Auburn · Cincinnati, OH
- Endocrinology Associates Inc · Columbus, OH
- Nexgen Research · Lima, OH
Pennsylvania · 3
- Heritage Valley Multispecialty Group Inc · Beaver, PA
- Capital Area Research LLC · Camp Hill, PA
- Abington Medical Specialists · Horsham, PA
Rhode Island · 1
- Velocity Clinical Research - Providence · East Greenwich, RI
South Carolina · 1
- Accellacare Charleston · Mt. Pleasant, SC
South Dakota · 1
- Monument Health Clinical Research · Rapid City, SD
Tennessee · 4
- Stern Cardiovascular Foundation Inc · Germantown, TN
- Accellacare of Knoxville · Knoxville, TN
- Cardiovascular Research of Knoxville North Knoxville Medical Center · Powell, TN
- Tennessee Center for Clinical Trials · Tullahoma, TN
Texas · 25
- PharmaTex Research, LLC · Amarillo, TX
- Austin Heart · Austin, TX
- Velocity Clinical Research - Austin · Austin, TX
- Cedar Health Research, LLC · Dallas, TX
- Soltero Cardiovascular Research Center · Dallas, TX
- Thyroid Endocrinology and Diabetes · Dallas, TX
- University of Texas Southwestern Medical Center · Dallas, TX
- Zenos Clinical Research · Dallas, TX
- Academy of Diabetes Thyroid and Endocrine · El Paso, TX
- David Turbay, MD · El Paso, TX
- Biopharma Informatic, LLC · Houston, TX
- Cardiovascular Specialists of Willowbrook · Houston, TX
- PlanIt Research, PLLC · Houston, TX
- Research Physicians Network, LLC · Houston, TX
- Vital Heart and Vein · Humble, TX
- Tcr Institute Llc · Kingwood, TX
- Helium Research Group · Lake Jackson, TX
- Epic Clinical Research · Lewisville, TX
- Biopharma Informatic-McAllen · McAllen, TX
- Southern Endocrinology Associates PA · Mesquite, TX
- North Hills Medical Research · North Richland Hills, TX
- Bandera Family Health Care · San Antonio, TX
- Consano Clinical Research - Shavano Park · Shavano Park, TX
- Sugar Lakes Family Practice · Sugar Land, TX
- Wichita Falls Heart Clinic · Wichita Falls, TX
Utah · 2
- Boeson Research · Provo, UT
- Velocity Clinical Research - Salt Lake City · West Jordan, UT
Virginia · 2
- Inova Cardiology - Fairfax · Fairfax, VA
- Virginia Heart · Falls Church, VA
Washington · 2
- VA Puget Sound Healthcare System · Seattle, WA
- Velocity Clinical Research - Spokane · Spokane, WA
West Virginia · 1
- Vaught Neurological Services · Crab Orchard, WV
Wisconsin · 1
- Aspirus Cardiovascular Associates · Wausau, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.