Aspirin Dose Escalation for the Prevention of Recurrent Preterm Delivery Trial
NCT06980025
This study is recruiting at 14 US sites in 10 states, according to its ClinicalTrials.gov record last updated .
Summary
This is a phase-III multi-center double-blind randomized clinical trial of 1,800 individuals with a history of prior preterm birth at less than 35 weeks gestation who are randomized to either 162 mg aspirin or 81 mg aspirin daily. The study drug will be initiated between 10 and 15 weeks gestation and continued through 36 weeks, 6 days gestation. The primary endpoint is recurrent preterm delivery or fetal death prior to 35 weeks, 0 days gestation.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Preterm Delivery
- Obstetrical Complications
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 3
- Ages
- 14 years and older
- Sex
- Female
- Healthy volunteers
- Accepted
- Sponsor
- The George Washington University Biostatistics Center
- Last updated on ClinicalTrials.gov
- April 9, 2026
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Alabama · 1
- University of Alabama - Birmingham · Birmingham, AL
California · 1
- Regents of the University of California San Francisco · San Francisco, CA
Illinois · 1
- Northwestern University · Chicago, IL
New York · 1
- Columbia University · New York, NY
North Carolina · 2
- University of North Carolina - Chapel Hill · Chapel Hill, NC
- Duke University · Durham, NC
Ohio · 2
- Case Western Reserve University · Cleveland, OH
- Ohio State University · Columbus, OH
Pennsylvania · 2
- Hospital of the University of Pennsylvania · Philadelphia, PA
- Magee Women's Hospital of UPMC · Pittsburgh, PA
Rhode Island · 1
- Brown University · Providence, RI
Texas · 2
- Baylor College of Medicine · Houston, TX
- University of Texas - Houston · Houston, TX
Utah · 1
- University of Utah Medical Center · Salt Lake City, UT
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.