Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
NCT06964464
This study is recruiting at 13 US sites in 11 states, according to its ClinicalTrials.gov record last updated .
Summary
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection fraction (HFrEF) and an implantable cardioverter defibrillator (ICD). The study will enroll 2,000 participants across 100 U.S. sites and includes an 18-month feasibility phase with 100 participants from 15 sites. Eligible participants must be currently treated with metoprolol succinate and willing to switch to carvedilol, with randomization in a 1:1 ratio.
Shortened from the sponsor's brief summary. View official record on ClinicalTrials.gov
Conditions studied
- Heart Failure With Reduced Ejection Fraction (HFrEF)
- Sudden Cardiac Death
- Ventricular Arrhythmia
- Implantable Cardioverter Defibrillator (ICD)
- Beta-blocker Therapy
- Cardiomyopathy
Eligibility basics and study details
- Study type
- Interventional
- Phase
- Phase 4
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Sponsor
- University of Rochester
- Last updated on ClinicalTrials.gov
- September 18, 2025
These are the basic criteria only. The full inclusion and exclusion criteria are on the official record, and the study team decides who can take part.
US recruiting sites
Arizona · 1
- HonorHealth · Scottsdale, AZ
Georgia · 1
- AdventHealth Redmond · Rome, GA
Kansas · 1
- AdventHealth Shawnee Mission · Shawnee Mission, KS
Michigan · 1
- Henry Ford Health System · Detroit, MI
Missouri · 1
- University of Mossouri · Columbia, MO
Nebraska · 1
- Creighton University Medical Center · Omaha, NE
New York · 3
- New York-Presbyterian Brooklyn Methodist Hospital · Brooklyn, NY
- Suny Downstate · Brooklyn, NY
- University of Rochester Medical Center · Rochester, NY
Texas · 1
- CHRISTUS Trinity Mother Frances Health System · Tyler, TX
Utah · 1
- Health University of Utah · Salt Lake City, UT
Virginia · 1
- Virginia Commonwealth University · Richmond, VA
Wisconsin · 1
- University of Wisconsin Hospital and Clinics · Madison, WI
Source: ClinicalTrials.gov, data processed . Recruiting US sites filtered by distance and site status; summaries shortened.